Preclinical News and Research

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Drug improves effectiveness of chemotherapy in ovarian cancer patients

An international research team, led by scientists from Mater Research - The University of Queensland, have discovered they can overcome chemotherapy resistance in an ovarian cancer subtype by using low doses of a drug which slows cell growth.

16 Apr 2020

Chronic stress can influence the efficacy of radiation therapy, study suggests

Radiation is one of the oldest and most common therapies for cancer, and typically is delivered locally, or to specific targeted sites in the body.

15 Apr 2020

Columbia University launches CovidWatcher app to track virus spread in NYC

Researchers from Columbia University have launched CovidWatcher, an app that surveys users about their exposure to the new coronavirus, symptoms, access to medical care, and impact on daily life.

13 Apr 2020

Molecular pathway responsible for TNBC's progression and spread identified

Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer, a particularly aggressive form of the disease, less than 20% respond.

13 Apr 2020

Large-scale proteomic analysis links glucose metabolism proteins and AD biology

In the largest study to date of proteins related to Alzheimer's disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers.

13 Apr 2020

Large-scale analysis links glucose metabolism proteins to Alzheimer's disease biology

A team has identified Alzheimer's disease-specific proteins and processes that could be used for treatment targets and biomarkers.

13 Apr 2020

Researchers discover inflammatory mechanism that contributes to autoimmune diseases

The protein STING (Stimulator of Interferon Genes) is a critical component of the body's innate immune defence system, but can also contribute to chronic autoimmune and autoinflammatory diseases.

8 Apr 2020

Preclinical trials for two coronavirus vaccine candidates commence

Scientists at CSIRO, Australia’s national science body, and the Australian Animal Health Laboratory (AAHL) in Geelong, Victoria, have commenced preclinical trials for two novel coronavirus vaccine candidates.

7 Apr 2020

Bill and Melinda Gates fund potential vaccine against COVID-19

In a race against time, teams of scientists across the world are working towards developing an effective and safe vaccine to prevent infection from the SARS-CoV-2 virus that causes COVID-19 disease.

7 Apr 2020

Metrion Biosciences and International Scientific Consortium publish data and new recommendations for in vitro risk assessment of the cardiac safety of new medicines

Metrion today announced it has contributed to two new peer-reviewed papers under the U.S. FDA CiPA (Comprehensive in vitro Proarrhythmia Assay) initiative.

From Metrion Biosciences Limited 7 Apr 2020

Researchers develop a unique radiochemical synthesis approach for treating cancer

Radiolabeled molecules, so-called radiotracers, help nuclear physicians to detect and precisely target tumors, which are often developing due to pathological changes in metabolic processes.

7 Apr 2020

Texas A&M chemists focus on searching for drugs to treat COVID-19

In the wake of the novel coronavirus pandemic, Texas A&M University chemist Wenshe Ray Liu and his research team have focused their lab solely on searching for drugs to treat COVID-19.

6 Apr 2020

New antiviral drug could change the way doctors treat COVID-19

Scientists are hopeful that a new drug -- called EIDD-2801 -- could change the way doctors treat COVID-19. The drug shows promise in reducing lung damage, has finished testing in mice and will soon move to human clinical trials.

6 Apr 2020

Alzheimer's disease: high amyloid levels linked to early disease

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD).

6 Apr 2020

New family of molecules to join altered receptors in Alzheimer's, Parkinson's and Huntington's

An article published in the Journal of Medicinal Chemistry shows a new family of molecules with high affinity to join imidazoline receptors, which are altered in the brain of those patients with neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's.

3 Apr 2020

Starving pancreatic cancer cells of cysteine may induce tumor ferroptosis

A new study from Columbia University Irving Medical Center and the Herbert Irving Comprehensive Cancer Center suggests a compound in development for a rare kidney stone disease may have potential against pancreatic cancer.

2 Apr 2020

Total-body PET provides suitable images of antibodies up to 30 days after injection

Combining 89Zr-labeled antibodies with total-body positron emission tomography (PET) has extended the utility of novel total-body PET scanners, providing suitable images up to 30 days after the initial injection.

31 Mar 2020

Stellenbosch University and AzarGen Biotechnologies join forces to tackle COVID-19

Stellenbosch University in South Africa and AzarGen Biotechnologies (Pty) Ltd, a South African biotechnology company focused on developing human therapeutic proteins using advanced genetic engineering and synthetic biology techniques in plants, have joined forces in the global fight against the coronavirus.

31 Mar 2020

New viable therapeutic strategy found for ER+ breast cancer

Researchers say they have found a viable new therapeutic strategy for estrogen receptor-positive (ER+) breast cancer, even cancers that are resistant to current standard of care treatments.

31 Mar 2020

Horizon Discovery and Pharmahungary report positive early-stage results for novel micro-RNA therapeutic for ischemic heart diseases

Horizon Discovery Group plc and Pharmahungary Group announced positive early-stage results for a novel micro-RNA therapeutic for ischemic heart diseases.

31 Mar 2020

Preclinical News and Research

Drug improves effectiveness of chemotherapy in ovarian cancer patients

Chronic stress can influence the efficacy of radiation therapy, study suggests

Columbia University launches CovidWatcher app to track virus spread in NYC

Molecular pathway responsible for TNBC's progression and spread identified

Large-scale proteomic analysis links glucose metabolism proteins and AD biology

Large-scale analysis links glucose metabolism proteins to Alzheimer's disease biology

Researchers discover inflammatory mechanism that contributes to autoimmune diseases

Preclinical trials for two coronavirus vaccine candidates commence

Bill and Melinda Gates fund potential vaccine against COVID-19

Metrion Biosciences and International Scientific Consortium publish data and new recommendations for in vitro risk assessment of the cardiac safety of new medicines

Researchers develop a unique radiochemical synthesis approach for treating cancer

Texas A&M chemists focus on searching for drugs to treat COVID-19

New antiviral drug could change the way doctors treat COVID-19

Alzheimer's disease: high amyloid levels linked to early disease

New family of molecules to join altered receptors in Alzheimer's, Parkinson's and Huntington's

Starving pancreatic cancer cells of cysteine may induce tumor ferroptosis

Total-body PET provides suitable images of antibodies up to 30 days after injection

Stellenbosch University and AzarGen Biotechnologies join forces to tackle COVID-19

New viable therapeutic strategy found for ER+ breast cancer

Horizon Discovery and Pharmahungary report positive early-stage results for novel micro-RNA therapeutic for ischemic heart diseases

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