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Study may suggest new therapeutic approaches to control immune responses

Researchers have provided new insight on the role of cyclic AMP (cAMP) in regulating the immune response.

5 Feb 2020

Novel hydrogels degrade while stem cells flourish for tissue repair

Baby diapers, contact lenses and gelatin dessert. While seemingly unrelated, these items have one thing in common -- they're made of highly absorbent substances called hydrogels that have versatile applications.

4 Feb 2020

New treatment target for acute kidney injury prevention revealed

Up to 10% of patients who are hospitalized or undergo surgery will experience acute kidney injury, and as many as 50% of patients in intensive care units will meet the criteria for AKI, the National Kidney Foundation has determined. Some of these patients will progress to kidney failure within months.

4 Feb 2020

3D-printed scaffolds engraved with grooves hold promise for healing injuries

Who ever said bioengineers can't get their groove on? The Rice University team led by Antonios Mikos says otherwise with its development of a groovy method to seed sophisticated, 3D-printed tissue-engineering scaffolds with living cells to help heal injuries.

4 Feb 2020

Advanced X-ray combination technique aids tuberculosis and osteoporosis research

With an advanced X-ray combination technique, scientists have traced nanocarriers for tuberculosis drugs within cells with very high precision.

4 Feb 2020

Making it all work: brain-dependent immune activation in embryos

How does the immune system develop its functionality? This has been an ongoing area of research for biologists. Now, a new study published in the journal NPJ Regenerative Medicine in February 2020 shows that in very early fetal life the brain must signal directions to the developing immune system to help it defend the body from infectious agents. This signaling markedly improves the capability of the embryo to survive when faced with bacterial infection.

4 Feb 2020

Renal stem cells can be isolated from urine

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the medical faculty of Heinrich Heine University-Duesseldorf under the directorship of Prof. Dr. James Adjaye have developed a protocol for the reproducible isolation and characterization of kidney stem cells, urine-derived renal progenitor cells (UdRPCs) from donors of distinct ages, gender and ethnicity.

4 Feb 2020

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

Calibr, the drug discovery and development division of Scripps Research, today announced that the U.S. Food and Drug Administration has given clearance to the Investigational New Drug (IND) application for Calibr's "switchable" CAR-T cell therapy, which is being evaluated for the treatment of certain cancers, including relapsed/refractory B-cell malignancies such as non-Hodgkin lymphoma and chronic lymphocytic leukemia.

3 Feb 2020

UTHSC researchers receive $1.98 million grant for novel approach to studying diabetes

A team of researchers in the University of Tennessee Health Science Center's College of Medicine has been awarded a $1.98 million grant from the National Institute of Diabetes and Digestive and Kidney Disease, a division of the National Institutes of Health, for a novel approach to studying diabetes.

3 Feb 2020

IU researchers receive $3 million NIH grants to study cell functions in the bone marrow

More than $3 million from the National Institutes of Health will allow Indiana University Melvin and Bren Simon Cancer Center researchers to improve understanding of the complex system of how hematopoietic stem cells survive and sustain their function in the bone marrow.

31 Jan 2020

New research could lead to 'breakthrough' for myelodysplastic syndrome

Korean researchers have observed cup-shaped red blood cells in the peripheral blood of a patient with myelodysplastic syndrome.

From Tomocube Inc. 30 Jan 2020

Study may help develop ibrutinib-based combination therapies for blood cancer

Chronic lymphocytic leukemia (CLL) is the most common form of blood cancer (leukemia) in the Western world, affecting approximately 1.2% of all cancer patients.

30 Jan 2020

New treatment target could change the outlook of patients at risk of kidney injury

Kidney injury is a dreaded complication of commonly performed procedures such as coronary angiography or cardiac surgery, often stopping physicians and patients in their tracks.

30 Jan 2020

Shape-shifting cells rush to repair the defect after bone injury

Conventional thinking is that bone regeneration is left to a small number of mighty cells called skeletal stem cells, which reside within larger groups of bone marrow stromal cells.

29 Jan 2020

New way to treat stroke using an already FDA-approved drug shows promise

Stroke is the third leading cause of death and disability in the United States. More than 87 percent are ischemic strokes, caused by obstruction of one or more cerebral arteries. With limited progress in developing treatments, there is a critical need for neuroprotective agents to effectively treat stroke.

29 Jan 2020

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Microbes are often seen as pathogens that cause disease, but the picture is actually more complex than that limited view.

28 Jan 2020

Study shows wide variability in cost for orthobiologic therapies

The use of orthobiologics is a hot trend in orthopedics, but new research from the University of Alabama at Birmingham shows wide variability in cost for these therapies.

28 Jan 2020

Bone marrow chip provides new strategy for understanding Shwachman-Diamond syndrome

A new research tool that mimics the behavior of diseased bone marrow provides a new strategy for understanding the bone marrow disease, Shwachman-Diamond syndrome, and hopefully, developing new treatments.

28 Jan 2020

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

Prostate cancer is the most commonly diagnosed cancer in England

In the health agency’s report, there were 49,029 diagnoses made in 2018, which is about 8,000 more than the previous year, surpassing breast cancer with 47,476 cases. Lung cancer followed with 38,996 cases. The new data reveals that there were more cancers detected in 2018 in men than in women, with a total of 15,228 cases and 151,452, respectively.

28 Jan 2020

Bone News and Research

Study may suggest new therapeutic approaches to control immune responses

Novel hydrogels degrade while stem cells flourish for tissue repair

New treatment target for acute kidney injury prevention revealed

3D-printed scaffolds engraved with grooves hold promise for healing injuries

Advanced X-ray combination technique aids tuberculosis and osteoporosis research

Making it all work: brain-dependent immune activation in embryos

Renal stem cells can be isolated from urine

FDA gives clearance to IND application for Calibr's 'switchable' CAR-T cell therapy

UTHSC researchers receive $1.98 million grant for novel approach to studying diabetes

IU researchers receive $3 million NIH grants to study cell functions in the bone marrow

New research could lead to 'breakthrough' for myelodysplastic syndrome

Study may help develop ibrutinib-based combination therapies for blood cancer

New treatment target could change the outlook of patients at risk of kidney injury

Shape-shifting cells rush to repair the defect after bone injury

New way to treat stroke using an already FDA-approved drug shows promise

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Study shows wide variability in cost for orthobiologic therapies

Bone marrow chip provides new strategy for understanding Shwachman-Diamond syndrome

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

Prostate cancer is the most commonly diagnosed cancer in England

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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