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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Online version of algorithm shows how biases in RNA sequences affect gene expression

A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences between tissues and cells alter gene expression without changing the underlying genetic code.

29 Jun 2022

Proteins in the eye may predict which macular degeneration patients need life-long treatment

In a study of eye fluid from 38 patients, Johns Hopkins Medicine researchers say they have found that levels of a specific protein appears to help accurately predict whether people with the wet form of age-related macular degeneration may need lifelong, frequent eye injections to preserve vision or if they can be safely weaned off the treatments.

29 Jun 2022

Anticancer drug candidate that targets a human protein could be a pan-viral medication

More than two years into the COVID-19 pandemic, people are realizing that the "new normal" will probably involve learning to co-exist with SARS-CoV-2. Some treatments are available, but with new variants emerging, researchers are looking toward new strategies.

29 Jun 2022

The distribution and dynamics of microbial populations on surfaces within a clinical microbiology lab during the COVID-19 pandemic

Researchers evaluated the distribution of microbes on surfaces within a microbiology laboratory.

29 Jun 2022

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Researchers assessed the impact of SARS-CoV-2 envelope protein on the bromodomain and extraterminal domain (BET) proteins.

29 Jun 2022

Highly active cells associated with growth and recurrence of brain glioma

Tumors are made up of many types of cells, both cancerous and benign. The specific complexity of the cells inside brain tumors has been a trademark of the disease, one that makes treatment extremely difficult. While scientists have long known about the variety of cells within a brain tumor, the ways these tumors grow has relied on the understanding that the cells are static, unmoving and relatively fixed.

29 Jun 2022

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Like many neurological diseases, there's a lot we don't understand about fragile X syndrome. But, after studying the disorder for several years, Lynne Maquat's lab knew two important things: the enzyme AKT, which plays a key role in cell growth and survival, and the quality control pathway known as NMD (nonsense-mediated mRNA decay), are both in overdrive in fragile X.

29 Jun 2022

Investigating the prerequisites for developing RNA-based antibiotics

In the fight against the Covid-19 pandemic, mRNA-based vaccines have impressively demonstrated their potential. Using this technology, scientists were able to rapidly develop and bring to market vaccines against SARS-CoV-2 that have been extremely effective at protecting millions of people against severe disease progression of COVID-19 or even death.

29 Jun 2022

Study explores antibody responses following three COVID vaccine doses in kidney transplant recipients

In a recent study posted to the medRxiv* pre-print server, Canadian researchers evaluated antibody responses in kidney transplant recipients (KTRs) before and one and three months after receiving the third dose of a messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine.

28 Jun 2022

Duke researchers identify role for key gene in developmental disability syndrome

A single gene that was previously found to be the driving force in a rare syndrome linked to epilepsy, autism and developmental disability has been identified as a linchpin in the formation of healthy neurons.

28 Jun 2022

New $5.3 million NIH grant will support researchers into understanding lung cancer recurrence

Researchers at Washington University School of Medicine in St. Louis are leading a national study aimed at identifying patients with early-stage lung cancer who are at high risk of having the cancer return, even after surgery and chemotherapy appear to have eliminated their tumors.

28 Jun 2022

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) and the IrsiCaixa AIDS Research Institute, a center jointly promoted by the "la Caixa" Foundation and the Department of Health of the Generalitat de Catalunya.

28 Jun 2022

RNA News and Research

Further Reading

Online version of algorithm shows how biases in RNA sequences affect gene expression

Proteins in the eye may predict which macular degeneration patients need life-long treatment

Anticancer drug candidate that targets a human protein could be a pan-viral medication

The distribution and dynamics of microbial populations on surfaces within a clinical microbiology lab during the COVID-19 pandemic

Study finds SARS-CoV-2 E protein antagonizes BET protein-mediated antiviral responses during infection

Highly active cells associated with growth and recurrence of brain glioma

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Investigating the prerequisites for developing RNA-based antibiotics

Study explores antibody responses following three COVID vaccine doses in kidney transplant recipients

Duke researchers identify role for key gene in developmental disability syndrome

New $5.3 million NIH grant will support researchers into understanding lung cancer recurrence

Antiretroviral drug used to treat HIV ameliorates cognitive deficits in mouse model of Down syndrome

New technique offers higher-precision scRNA-seq data than current technologies

Genome analysis of alphacoronavirus and betacoronavirus species from South Korean bats

Evolution of SARS-CoV-2 genomes based on continuing positive selection

Researchers analyze potential of niclosamide as a SARS-CoV-2 treatment

Lipid-peptide nanocomplexes offer new mRNA platform

Chemically modified rocaglates have a stronger effect against viral replication

Comparison of genome sequences of SARS-CoV-2 and other coronaviruses

Antigenic differences between early SARS-CoV-2 variants

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