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Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University's Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children's Hospital of Philadelphia, the University of Pennsylvania, and the Valley Hospital Heart Institute.

29 Jan 2023

Researchers discover how measles virus can cause a rare but fatal neurological disorder

Researchers in Japan have uncovered the mechanism for how the measles virus can cause subacute sclerosing panencephalitis, or SSPE, a rare but fatal neurological disorder that can occur several years after a measles infection.

27 Jan 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

Activated neutrophils can become potent cancer fighters

Elevated levels of immune cells, called neutrophils, in tumors have been associated with poor outcomes in people with cancer.

27 Jan 2023

Treatment to boost white blood cells may benefit patients with glioblastoma

A new study led by Washington University School of Medicine in St. Louis reveals at least one cause of low white blood cell counts in patients treated for glioblastoma and demonstrates a potential treatment strategy that improves survival in mice.

27 Jan 2023

Top urologists share their insights and practical tips at "Urology on the Beach"

Desai Sethi Urology Institute brings renowned thought leaders to Miami Beach. From urologic cancers to female urology to male infertility to kidney stones and sexual health, top urologists from throughout the nation shared their insights and practical tips at "Urology on the Beach," a conference hosted January 13-15 by the Desai Sethi Urology Institute at the University of Miami Miller School of Medicine.

27 Jan 2023

Chemotherapy in the afternoon proved to be effective for female lymphoma patients

Chemotherapy is a commonly used regimen for cancer treatment, but it is also a double-edged sword. While the drugs are highly effective at killing cancer cells, they are also notorious for killing healthy cells in the body.

27 Jan 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells.

27 Jan 2023

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

Microtubules are cellular fibres that are part of the skeleton of the cell, termed cytoskeleton. They ensure that cells maintain their shape, carry out their functions, and divide.

27 Jan 2023

Children’s immune systems do not develop ‘adaptive’ memory to protect against second time SARS-CoV-2 infection

Children have largely avoided severe COVID-19 symptoms because they have a strong initial 'innate' immune reaction that quickly defeats the virus.

26 Jan 2023

AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

26 Jan 2023

Study reveals why hypoglycemic episodes worsen diabetic retinopathy

People with diabetes who experience periods of low blood sugar — a common occurrence in those new to blood sugar management — are more likely to have worsening diabetic eye disease.

26 Jan 2023

Pancreatic cancer study reveals the cause of tumor cell resistance to immunotherapy

A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.

26 Jan 2023

Combination of targeted therapies with immunotherapy addresses treatment resistance in pancreatic cancer

A team of investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine has shown for the first time that a combination of targeted therapies with immunotherapy addresses one of the major reasons pancreatic cancer is so notoriously treatment resistant.

26 Jan 2023

Study shows mechanical tearing as a novel mechanism during neurite pruning

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B Cell News and Research

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Researchers discover how measles virus can cause a rare but fatal neurological disorder

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

Activated neutrophils can become potent cancer fighters

Treatment to boost white blood cells may benefit patients with glioblastoma

Top urologists share their insights and practical tips at "Urology on the Beach"

Chemotherapy in the afternoon proved to be effective for female lymphoma patients

Protein adduction and p53 tumor suppressor inhibition

Researchers identify an unexpected driver of cancer immunotherapy resistance

Researchers discover a key role played by ch-TOG protein in the initiation of microtubule assembly

Children’s immune systems do not develop ‘adaptive’ memory to protect against second time SARS-CoV-2 infection

AI tool promises to accelerate the development of gene therapies on a large scale

Study reveals why hypoglycemic episodes worsen diabetic retinopathy

Pancreatic cancer study reveals the cause of tumor cell resistance to immunotherapy

Combination of targeted therapies with immunotherapy addresses treatment resistance in pancreatic cancer

Study shows mechanical tearing as a novel mechanism during neurite pruning

Study identifies the DNA roots of resistance to targeted cancer therapy

New collection of month-specific infant brain atlas captures fine details of the early developing brain

Persistent tumor mutation burden linked with therapeutic response to immunotherapy

PLK1-mTOR axis may be a promising therapeutic target for sepsis, study suggests

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