Chromatin News and Research

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REDH database provides insights into RNA editing in hematopoietic cells

The process of converting DNA to proteins through an RNA is far from straightforward. Of the several types of RNA involved in the process of protein synthesis, a few may be edited mid-way.

10 Jul 2023

Pyroptosis: A potential therapeutic target for lung cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

28 Jun 2023

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Researchers performed a protein diffusion network analysis using tissue-specific GRNs to identify predispositions to COVID-19.

21 Jun 2023

Scientists develop new technique to peer into the genome's spatial architecture

People who owned black-and-white television sets until the 1980s didn't know what they were missing until they got a color TV.

19 Jun 2023

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Researchers reported on the contribution of trained immune responses to protection against SARS-CoV-2 infections and future pandemics.

16 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Entry of the SARS-CoV-2 virus into human tissues depends on the activity of a host gene that regulates production of a key viral receptor, according to a study publishing June 13th in the open access journal PLOS Biology by Madison Strine and Craig Wilen of Yale University, US, and colleagues.

13 Jun 2023

Study illuminates how T cells fight and remember infections

The immune system protects the body from invaders, such as bacteria, viruses, or tumors, with its intricate network of proteins, cells, and organs.

13 Jun 2023

Obesity strikes below the belt: Study reveals link between obesity and male infertility

The influence of obesity on male fertility is still under debate. In the present investigation, researchers scrutinized semen samples from both obese individuals and those of normal weight. The aim was to explore the relationship between obesity, the length of sperm telomeres, levels of mRNA associated with autophagy, and diverse semen characteristics.

29 May 2023

Artificial intelligence in sperm selection for assisted reproduction

Researchers summarize available evidence on the application of artificial intelligence and machine learning in sperm selection.

29 May 2023

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage - a cause and consequence of many diseases.

22 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

New approaches to promote healthspan from an epigenetic perspective

A new review paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 8, entitled, "How can we modulate aging through nutrition and physical exercise? An epigenetic approach."

10 May 2023

Climate change linked to changes in gut microbiota and aging process

Research paper explores the relationship between aging, gut microbiota, and climate change. It discusses how climate change can affect the composition of gut microbiota, which in turn can impact the aging process.

26 Apr 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

New finding in roundworms upends classical thinking about animal cell differentiation

Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

7 Apr 2023

Chromatin News and Research

REDH database provides insights into RNA editing in hematopoietic cells

Pyroptosis: A potential therapeutic target for lung cancer

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Scientists develop new technique to peer into the genome's spatial architecture

Trained immunity: its role in COVID-19 and potential in preparing for future infectious outbreaks

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

DYRK1A gene may dictate susceptibility to multiple highly pathogenic coronaviruses

Study illuminates how T cells fight and remember infections

Obesity strikes below the belt: Study reveals link between obesity and male infertility

Artificial intelligence in sperm selection for assisted reproduction

Researchers produce a multi-scale map of protein assemblies in the DNA damage response

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

New approaches to promote healthspan from an epigenetic perspective

Climate change linked to changes in gut microbiota and aging process

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

New finding in roundworms upends classical thinking about animal cell differentiation

New model of DNA flexibility opens up the possibility of getting closer to the chromatin scale

Epigenome reprogramming after SARS-CoV-2 infection

Menin protein protects against aging and cognitive decline

Researchers uncover new clue as to how "whole genome doubling" drives cancer

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