Cytotoxicity News and Research

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Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

In a new study published in ACS Infectious Diseases journal, scientists biochemically and structurally evaluated the PLpro from a subgroup 2b bat coronavirus, BtSCoV-Rf1.2004, to identify unique structural features or enzymatic biases of the subgroup 2b.

28 Feb 2022

Omicron neutralizing titers after third BNT162b2 dose are persistent

The new study, published in the journal Cell Host and Microbe, also finds that the neutralization against Omicron remains robust at four months after the third dose of the BNT162b2 vaccine.

22 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

mRNA COVID-19 vaccine shown to induce afucosylated antibodies in individuals without prior SARS-CoV-2 exposure

New study findings reveal that the level of afucosylated anti-spike antibodies increases transiently in infection-naïve individuals after the first COVID-19 vaccine dose.

17 Feb 2022

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa.

16 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.

2 Feb 2022

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

Scientists have recently used synthetic biology to design primary human CD8 T cells to express Spike protein-specific chimeric antigen receptors (ACE2 CAR or anti-Spike CAR).

25 Jan 2022

PFAS found in high levels in anti-fogging sprays

We speak to Professor Heather Stapleton and Dr. Nicholas Herkert about their latest research that led to the discovery of high levels of PFAS in anti-fogging sprays.

24 Jan 2022

Nirmatrelvir, Molnupiravir, and Remdesivir hold-up against SARS-CoV-2 Omicron variant in vitro

In a recent study posted to the bioRxiv* preprint server, researchers test three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals authorized for emergency use by the United States Food and Drug Administration (FDA) for their in vitro potency against several SARS-CoV-2 variants, including the currently dominant Omicron train.

23 Jan 2022

Novel compound found in mussels helps increase the durability of dental fillings

Leading researchers from the Faculty of Dentistry, the University of Hong Kong, Wuhan University, and the Peking University Shenzhen Hospital have found that a compound found in mussels helps increase the durability of a dental filling.

22 Jan 2022

Discovery illuminates a blueprint to develop new antibiotics for killing bacteria

The Centers for Disease Control and Prevention estimates that more than 2.8 million Americans experience antibiotic-resistant infections each year; more than 35,000 die from those infections.

20 Jan 2022

Prospective of graphene and graphene-based derivatives to combat SARS-CoV-2 infection

Researchers explored the utilities of graphene and its derivatives in combating SARS-CoV-2, highlighting its applications in the biomedical domain.

20 Jan 2022

SARS-CoV-2 interacts with heparan sulfate to activate the alternative pathway

A new study discusses the activation of the complement system to determine its role in COVID-19-related deaths.

17 Jan 2022

Small molecule identified as a SARS-CoV-2 inhibitor

A new study published in iScience reports the results of a screening strategy to identify small molecules that target viral entry to block infection with this virus.

6 Jan 2022

Host kinase identified as an inhibition target for SARS-CoV-2

In this experiment, the chemical probe SGC-CK2-1 inhibited virus replication at nanomolar concentration, showing a highly selective effect on the kinase.

6 Jan 2022

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

Standard chemotherapies may efficiently kill cancer cells, but they also pose significant risks to healthy cells, resulting in secondary illness and a diminished quality of life for patients. To prevent the previously unavoidable damage, researchers, led by Penn State, have developed a new class of nanomaterials engineered to capture chemotherapy drugs before they interact with healthy tissue.

6 Jan 2022

Cytotoxicity News and Research

Noncovalent protease inhibitors against SARS-CoV-2 and other coronaviruses

Omicron neutralizing titers after third BNT162b2 dose are persistent

Ensitrelvir, a novel SARS-CoV-2 antiviral

mRNA COVID-19 vaccine shown to induce afucosylated antibodies in individuals without prior SARS-CoV-2 exposure

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

Nitazoxanide shows promise for COVID-19 treatment in animal model

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Development of synthetic molecules that can bridge T cells with SARS-CoV-2 infected cells

PFAS found in high levels in anti-fogging sprays

Nirmatrelvir, Molnupiravir, and Remdesivir hold-up against SARS-CoV-2 Omicron variant in vitro

Novel compound found in mussels helps increase the durability of dental fillings

Discovery illuminates a blueprint to develop new antibiotics for killing bacteria

Prospective of graphene and graphene-based derivatives to combat SARS-CoV-2 infection

SARS-CoV-2 interacts with heparan sulfate to activate the alternative pathway

Small molecule identified as a SARS-CoV-2 inhibitor

Host kinase identified as an inhibition target for SARS-CoV-2

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

COVID-19 mRNA vaccines offer protection against Omicron variant in pregnancy

Oral bacteria-based SARS-CoV-2 vaccine platform

Omicron spike-specific binding antibodies attenuate disease, despite increasing transmission

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