Immunodeficiency News and Research

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Immunodeficiency (or immune deficiency) is a state in which the immune system's ability to fight infectious disease is compromised or entirely absent.

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

Researchers assessed the effectiveness of SARS-CoV and SARS-CoV-2 envelope proteins against HIV-1.

22 Nov 2022

β-cyclodextrin family found to be promising and cost-effective antiviral agents against SARS-CoV-2

Researchers identified β-cyclodextrins (β-CDs) as a safe and cost-effective drug against SARS-CoV-2 with a broad spectrum of activity.

18 Nov 2022

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

Researchers from Sweden conducted a cohort study to evaluate the protection granted by previous SARS-CoV-2 Omicron subvariant infections against reinfections among individuals vaccinated between June and August 2022.

17 Nov 2022

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Researchers evaluated dose-sparing strategies for monkeypox (MPX) vaccination using mathematical modeling.

17 Nov 2022

Study reveals neglected or late TB diagnoses related to COVID-19

In a recent study published in the journal BMJ Medicine, researchers modeled changing patterns in sex- and age-stratified new and relapse tuberculosis (TB) case notifications reported to the World Health Organization (WHO) for 45 nations with high TB, TB/human immunodeficiency virus (HIV) and multidrug-resistant TB (MDR-TB) burden between 2013 and 2019 due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

16 Nov 2022

Black, Hispanic MSM disproportionately affected by monkeypox

A recent study published in the Morbidity and Mortality Weekly Report described the epidemiologic characteristics of the monkeypox (MPX) outbreak in the United States (US).

15 Nov 2022

The origin of COVID-19: wildlife trade rather than laboratory leak?

A recent opinion piece published in PNAS discussed the sequence of events concerning the COVID-19 pandemic to provide evidence against the alleged leak of SARS-CoV-2 and the Ebola virus from viral research laboratories in Wuhan, China, and West Africa, respectively.

15 Nov 2022

Researchers provide new insights into the vexing process that makes HIV stealthy

An immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew, researchers at Duke Health report.

14 Nov 2022

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Researchers investigated the early T cell responses during SARS-CoV-2 infections to understand the mechanisms of rapid clonal expansion that characterize the T cell responses to acute infections and vaccinations.

14 Nov 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

How lessons from the HIV epidemic can help combat COVID-19

Researchers revisit lessons learned from the HIV pandemic in response to COVID-19.

13 Nov 2022

People living with HIV found to have a significantly delayed internal body clock

People living with HIV have a significantly delayed internal body clock, consistent with the symptoms of jet lag, according to new findings reported by researchers from universities in South Africa and the UK.

10 Nov 2022

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Researchers used a deep antibody-antigen interaction (DeepAAI) algorithm to understand the antibody representations of unseen antibodies to accelerate the discovery of novel antibodies with potential therapeutic applications.

9 Nov 2022

Mortality rate and risk among hospitalized COVID-19 patients during different surges of the pandemic

Researchers assessed the mortality rates associated with SARS-CoV-2 Alpha (B.1.1.7) and Delta (B.1.617.2) variant infections.

9 Nov 2022

Modeling predicts a declining trend in monkeypox cases globally and on a country-specific scale

In a recent study posted to the medRxiv* server, researchers at Georgia State University, USA, generated short-term forecasts of new monkeypox cases using an ensemble and subepidemic model.

7 Nov 2022

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Researchers identified a genetic association signal, via genome-wide association studies, between severe COVID-19 with systemic lupus erythematosus, an autoimmune disease.

7 Nov 2022

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

Researchers longitudinally followed up hospitalized (H) and non-hospitalized (NH) COVID-19 patients for six months after laboratory-confirmed SARS-CoV-2 infections to identify factors that increase the risk of post-COVID-19 condition development in the South African population.

4 Nov 2022

Immunodeficiency News and Research

Further Reading

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

β-cyclodextrin family found to be promising and cost-effective antiviral agents against SARS-CoV-2

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

When is it best to use dose-sparing vaccination strategies for monkeypox to protect more people?

Study reveals neglected or late TB diagnoses related to COVID-19

Black, Hispanic MSM disproportionately affected by monkeypox

The origin of COVID-19: wildlife trade rather than laboratory leak?

Researchers provide new insights into the vexing process that makes HIV stealthy

Study suggests the rapid expansion of naïve T cells can provide a fast and effective immune response to SARS-CoV-2 and other viral infections

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

How lessons from the HIV epidemic can help combat COVID-19

People living with HIV found to have a significantly delayed internal body clock

Researchers propose a deep antibody-antigen interaction algorithm to accelerate the identification of potential therapeutic antibodies

Mortality rate and risk among hospitalized COVID-19 patients during different surges of the pandemic

Modeling predicts a declining trend in monkeypox cases globally and on a country-specific scale

Shared genetic effects between the autoimmune disease systemic lupus erythematosus and the clinical consequences of COVID-19

Persistent COVID-19 symptoms among South Africans infected during SARS-CoV-2 Beta, Delta and Omicron variant waves

What is the role of cyclophilin-A in alleviating SARS-CoV-2 infections?

The maternal RSV vaccine from Pfizer protects newborns against severe illness

How does the ISG15/ISGylation system modulate Vaccinia virus infection?

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