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Zika virus exposure during pregnancy permanently shapes offspring's frontline immune cells

A Wayne State University study published in the Oct. 3, 2025, issue of Nature Communications revealed that Zika virus exposure during pregnancy causes long-term, sex-specific changes to a baby's immune system, particularly affecting the frontline immune cells that fight infection.

6 Oct 2025

Deadly brain cancer erodes skull bone and alters immune marrow

Scientists at Montefiore Einstein Comprehensive Cancer Center (MECCC) and Albert Einstein College of Medicine have shown for the first time that glioblastoma-the deadliest form of brain cancer-affects not just the brain but also erodes the skull, alters the makeup of skull marrow, and interferes with the body's immune response.

3 Oct 2025

Study uncovers cerebellar involvement and social impairment

Spinal muscular atrophy is a rare genetic disease of the nerve cells in the spinal cord that can appear as early as infancy. The disease leads to a progressive loss of muscle strength. Those affected often suffer from muscle weakness early on, as well as difficulties with movement, breathing, and swallowing.

3 Oct 2025

Negative behavioral effects of psilocybin persist in mouse mothers and offspring

Magic mushrooms may not be the answer to postpartum depression, new research from the University of California, Davis suggests.

30 Sep 2025

Researchers design factor IX variants for short- and long-term Hemophilia B management

After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

30 Sep 2025

New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

A team of scientists at Texas Tech University Health Sciences Center (TTUHSC) has published new evidence suggesting that the brain's protective shield - known as the blood-brain barrier (BBB) - remains largely intact in a commonly used mouse model of Alzheimer's disease.

29 Sep 2025

Precision probiotics lower blood sugar and cholesterol in mice

Researchers developed a precision probiotic cocktail comprising three Lactobacillus strains that improved glucose control, reduced weight gain, and lowered cholesterol levels in mice fed a high-fat diet. Metabolomic and microbiome analyses revealed host metabolic adaptations and beneficial shifts in gut bacteria, highlighting translational potential for future clinical trials.

28 Sep 2025

Can roselle help fight inflammation? New review suggests strong potential

A new review highlights the anti-inflammatory potential of Hibiscus sabdariffa (roselle), synthesizing evidence from 25 studies published between 2019 and 2024. Most findings are from preclinical models, but they point to promising roles in cardiovascular, metabolic, neuroprotective, and anticancer health.

28 Sep 2025

Gut probiotic Christensenella tenuis reduces endotoxemia and improves metabolism in obese mice

This study is reported by the team of Professor Shuang-jiang Liu from Shandong University. The study reveals that the gut probiotic Christensenella tenuis significantly alleviates endotoxemia and metabolic disorders in a diet-induced obesity (DIO) mouse model by modulating gut bile acids (BAs) metabolism and suppressing lipopolysaccharide (LPS) translocation across the gut barrier.

26 Sep 2025

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Globally recognized figures like Muhammad Ali and Michael J. Fox have long suffered from Parkinson's disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability.

26 Sep 2025

Calcium-induced release identified as key driver of dangerous muscle disorders

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

25 Sep 2025

Genetic modification enhances "living drugs" for blood cancers

CAR T cells are patient-derived, genetically engineered immune cells. They are "living drugs" and constitute a milestone in modern medicine. Equipping T cells, a key cell type of the immune system, with a "chimeric antigen receptor" (CAR) enables them to specifically recognize and attack cancer cells.

25 Sep 2025

Loss of Trp53 gene affects immune responses in ovarian cancer

A new research paper was published in Volume 16 of Oncotarget on September 22, 2025, titled "Loss of Trp53 results in a hypoactive T cell phenotype accompanied by reduced pro-inflammatory signaling in a syngeneic orthotopic mouse model of ovarian high-grade serous carcinoma."

24 Sep 2025

Study provides new insights into the mechanisms of fetal membrane healing

When a pregnant woman's water breaks too early, it often leads to preterm birth, with no effective method to prevent or treat it.

23 Sep 2025

UCLA researchers identify proteins that guard the liver against damage during transplantation

In a mouse model of liver transplantation, UCLA researchers have identified proteins that act as "protective switches" guarding the liver against damage occurring when blood supply is restored during transplantation, a process known as ischemia-reperfusion injury.

23 Sep 2025

Study reveals a new oncogenic role of NBL1 in ovarian cancer metastasis

Ovarian cancer (OC), one of the three most common gynecological malignancies, is characterized by low early detection rates and poor prognosis.

23 Sep 2025

New research links postictal symptoms in epilepsy to hidden brain waves

In everyday clinical practice, symptoms are regularly observed after epileptic seizures, known as "post-ictal symptoms", which, in contrast to the usually short duration of seizures, typically last several minutes to hours. Besides symptoms such as impaired speech and language comprehension, a state of disorientation may occur.

19 Sep 2025

Researchers identify seizure-associated depolarization as cause of post-ictal symptoms

People with temporal lobe epilepsy in particular often wander around aimlessly and unconsciously after a seizure. Researchers at the University Hospital Bonn (UKB), the University of Bonn, and the German Center for Neurodegenerative Diseases (DZNE) have identified a neurobiological mechanism that could be responsible for this so-called post-ictal wandering and potentially other postictal symptoms.

18 Sep 2025

Triple negative breast cancer exploits lymph node niches to block immune defense

In almost all solid tumors - i.e. cancers with a solid tissue structure - the detection of tumor cells in the lymph nodes is considered a decisive marker for the progression of the disease.

16 Sep 2025

Boosting PI31 to restore synaptic function and prevent neurodegeneration

One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the delicate machinery that keeps neurons in touch-by clearing away protein waste at the synapses-starts to fail.

16 Sep 2025

Mouse Model News and Research

Zika virus exposure during pregnancy permanently shapes offspring's frontline immune cells

Deadly brain cancer erodes skull bone and alters immune marrow

Study uncovers cerebellar involvement and social impairment

Negative behavioral effects of psilocybin persist in mouse mothers and offspring

Researchers design factor IX variants for short- and long-term Hemophilia B management

New evidence shows blood-brain barrier remains intact in Alzheimer's mouse model

Precision probiotics lower blood sugar and cholesterol in mice

Can roselle help fight inflammation? New review suggests strong potential

Gut probiotic Christensenella tenuis reduces endotoxemia and improves metabolism in obese mice

Optogenetics and artificial intelligence open path to personalized Parkinson’s treatment

Calcium-induced release identified as key driver of dangerous muscle disorders

Genetic modification enhances "living drugs" for blood cancers

Loss of Trp53 gene affects immune responses in ovarian cancer

Study provides new insights into the mechanisms of fetal membrane healing

UCLA researchers identify proteins that guard the liver against damage during transplantation

Study reveals a new oncogenic role of NBL1 in ovarian cancer metastasis

New research links postictal symptoms in epilepsy to hidden brain waves

Researchers identify seizure-associated depolarization as cause of post-ictal symptoms

Triple negative breast cancer exploits lymph node niches to block immune defense

Boosting PI31 to restore synaptic function and prevent neurodegeneration

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