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New imaging method reveals nanodomains inside ALS-linked protein droplets

Inside the cell reside many tiny assembly factories and warehouses that gather together all of the proteins and RNAs-which carry out instructions from our DNA-that a living being needs.

26 Nov 2025

New study links inherited mitochondrial DNA mutation to disrupted immune balance

Scientists have discovered how a mitochondrial mutation rewires immune function in a model of inherited primary mitochondrial disorders, which often lead to severe disability and death.

26 Nov 2025

Researchers discover new mutation hotspot in the human genome

Researchers have discovered new regions of the human genome particularly vulnerable to mutations. These altered stretches of DNA can be passed down to future generations and are important for how we study genetics and disease.

26 Nov 2025

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

A new paper from the University of Kansas overturns the idea that a "risk gene" carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

25 Nov 2025

New medication offers potential treatment for patients with deadliest form of blood cancer

Biomedical research that began at the University of Virginia School of Medicine has yielded a much-needed new treatment for patients with the deadliest form of blood cancer.

25 Nov 2025

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

A new study published in the Journal of Biological Chemistry from UC Davis Comprehensive Cancer Center finds that TIGIT, an immune checkpoint receptor targeted by cancer immunotherapy drugs, triggers a different response in rhesus macaques compared to humans.

24 Nov 2025

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

Arginine reduced amyloid beta aggregation in vitro and in both Drosophila and AppNL-G-F mouse models of Alzheimer’s disease, leading to fewer dense-core plaques and improved behavior. The study provides preclinical evidence that oral arginine may modulate amyloid pathology, although high dosing requirements and model limitations constrain human translation.

24 Nov 2025

New discovery could reshape how scientists think about Alzheimer’s treatment

Rutgers neuroscientist Peng Jiang was visiting his hometown of Qianshan, a city in China's Anhui province, when a neighbor came to his parents' house with a story that would stay with him.

24 Nov 2025

New sequencing method reveals how transposons move and shape the genome

Cornell researchers have found that a new DNA sequencing technology can be used to study how transposons move within and bind to the genome.

22 Nov 2025

Oral arginine reduces amyloid buildup in Alzheimer’s models

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is one of the leading causes of dementia worldwide, and currently has no definitive cure. Although antibody-based therapies that target amyloid β (Aβ) have recently been developed, their clinical effectiveness remains limited.

21 Nov 2025

New type of mitochondrial DNA damage revealed

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress.

20 Nov 2025

Neoantigens-loaded DC vaccines show strong potential to overcome tumor resistance

Despite the success of immune checkpoint inhibitors in revolutionizing oncology, their benefits remain limited to a small fraction of patients.

19 Nov 2025

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Researchers at the University of Eastern Finland and their international collaborators have identified key developmental and molecular differences between the two main subtypes of chronic lymphocytic leukemia, CLL.

18 Nov 2025

Dysfunctional mitochondria shown to initiate the onset of Parkinson's

For decades, scientists have known that mitochondria, which produce energy inside our cells, malfunction in Parkinson's disease.

17 Nov 2025

T cells drive vaccine effectiveness against porcine reproductive and respiratory syndrome virus

A new study shows that the effectiveness of current vaccines against porcine reproductive and respiratory syndrome virus (PRRSV) is due to the response of T cells against the disease, rather than the production of antibodies.

17 Nov 2025

Innovative CRISPR strategy resensitizes lung cancer to treatment

In a major step forward for cancer care, researchers at ChristianaCare's Gene Editing Institute have shown that disabling the NRF2 gene with CRISPR technology can reverse chemotherapy resistance in lung cancer.

17 Nov 2025

Study finds increased rates of DNA mutations in mice pups conceived with IVF

Mice pups conceived with in vitro fertilization (IVF) in the lab have slightly increased rates of DNA errors, or mutations, compared to pups conceived naturally, a new study on artificial reproductive technologies suggests.

17 Nov 2025

Study highlights need for XDP specific diagnostic assays

Scientists at Brigham and Women's Hospital and Harvard Medical School have developed a targeted genetic test to improve diagnosis for X-linked dystonia-parkinsonism (XDP), a rare and disabling movement disorder that affects primarily men of Filipino ancestry.

17 Nov 2025

Enhancing the cancer-immunity cycle through innovative vaccines

Therapeutic cancer vaccines have experienced a remarkable resurgence over the past decade, representing a paradigm shift in oncology toward harnessing the immune system's intrinsic ability to combat malignancies.

14 Nov 2025

Stanford scientists discover unexpected cancer resistance in aged mice

Old laboratory mice develop substantially fewer and less-aggressive lung tumors than younger animals in a new study led by Stanford University researchers.

12 Nov 2025

Mutation News and Research

New imaging method reveals nanodomains inside ALS-linked protein droplets

New study links inherited mitochondrial DNA mutation to disrupted immune balance

Researchers discover new mutation hotspot in the human genome

Study overturns assumptions about PTPN22 risk gene’s role in interferon production

New medication offers potential treatment for patients with deadliest form of blood cancer

New research questions reliability of macaque models for TIGIT-targeted cancer treatments

Arginine slows amyloid buildup and improves brain outcomes in Alzheimer’s disease models

New discovery could reshape how scientists think about Alzheimer’s treatment

New sequencing method reveals how transposons move and shape the genome

Oral arginine reduces amyloid buildup in Alzheimer’s models

New type of mitochondrial DNA damage revealed

Neoantigens-loaded DC vaccines show strong potential to overcome tumor resistance

Researchers identify key differences between two subtypes of chronic lymphocytic leukemia

Dysfunctional mitochondria shown to initiate the onset of Parkinson's

T cells drive vaccine effectiveness against porcine reproductive and respiratory syndrome virus

Innovative CRISPR strategy resensitizes lung cancer to treatment

Study finds increased rates of DNA mutations in mice pups conceived with IVF

Study highlights need for XDP specific diagnostic assays

Enhancing the cancer-immunity cycle through innovative vaccines

Stanford scientists discover unexpected cancer resistance in aged mice

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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