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Real-world effectiveness of the bivalent vaccine for preventing COVID-19 hospitalizations in non-hospitalized subjects

Researchers investigated the efficacy of a booster dose of the bivalent mRNA COVID-19 vaccine in preventing severe outcomes during SARS-CoV-2 infections.

11 Jan 2023

Spike protein mutations in Omicron subvariants increase their susceptibility to reductive cleavage of disulfide bonds

Researchers discovered that the spike protein of SARS-CoV-2 is susceptible to cleavage at the disulfide bonds, and the vulnerability to reductive cleavage varies across variants, with the Omicron variant family being highly susceptible to reduction.

10 Jan 2023

Study explores incidence, severity, and long COVID associations of SARS-CoV-2 reinfections

Researchers used electronic health records to characterize the incidence, biomarkers, attributes, and severity of SARS-CoV-2 reinfections and evaluated the association between reinfections and long coronavirus disease (COVID).

10 Jan 2023

Profound immune escape by SARS-CoV-2 XBB.1 even after 4 vaccine doses

In a recent correspondence published in The Lancet Infectious Diseases journal, researchers in Germany assessed the neutralization sensitivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB.1 lineage.

9 Jan 2023

Deletions in the antigenic regions in SARS-CoV-2 increase transmission and immune evasion ability

A recent study published in the journal Scientific Reports examined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole genome data to determine the deletion mutations around the spike protein region associated with increased transmission of the virus and identified an increase in the deletion-prone spike protein regions indicating an evolution strategy for immune escape.

9 Jan 2023

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

In a recent study posted to bioRxiv*, researchers designed a nanoparticle (NP)-conjugated toll-like receptor 9 (TLR9) agonist to improve the adjuvanticity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

8 Jan 2023

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

A recent study published in the journal Circulation examines the immunological picture in this scenario, looking for clues to the etiology of this rare and potentially serious complication.

5 Jan 2023

Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches

Scientists have described the utility of gram-negative bacteria-derived outer membrane vesicles as vaccines and methods to expand their applications.

3 Jan 2023

Effects of hybrid immunity on humoral immune response following COVID mRNA vaccination in a cohort of essential and frontline workers

Researchers longitudinally evaluated humoral immune responses to the second and third doses of COVID-19 mRNA vaccines among individuals with and without prior history of SARS-CoV-2 infections.

3 Jan 2023

What is the impact of COVID-19 on the human genetic architecture?

Researchers recently described the second update on the study of human genetic architecture with respect to the effect of coronavirus disease 2019 (COVID-19).

3 Jan 2023

BA.4/BA.5 mutations reduced responsiveness of epitope-specific T cells with original mRNA vaccine

A new study in the journal Viruses examines the phenomenon of breakthrough infections due to the evasion of T-cell immunity by the Omicron BA.4/BA.5 subvariants, showing this to be due to spike gene mutations.

2 Jan 2023

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

Researchers evaluated the efficacy of small molecule drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro.

29 Dec 2022

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Researchers evaluated plasma samples from individuals vaccinated with a fourth booster dose of mono- or bivalent mRNA SARS-CoV-2 vaccine to evaluate the recognition and neutralization capacity against the ancestral (D614G) strain and the Omicron BQ.1.1 subvariant.

23 Dec 2022

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

A recent Nature Cancer study documented that individuals with B cell lymphomas (LY) and multiple myeloma (MM) developed potent infection neutralization capabilities against several SARS-CoV-2 variants of concern (VoCs).

22 Dec 2022

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

Omicron subvariants effectively escape B-cell immune responses by modifying neutralizing antibody epitopes.

21 Dec 2022

MHRA authorizes the COVID-19 vaccine developed by Sanofi

VidPrevtyn Beta, the COVID-19 vaccine developed by Sanofi, has been authorised by the Medicines and Healthcare products Regulatory Agency (MHRA).

21 Dec 2022

COVID-19 epidemiology can be estimated using blood donation samples

An article published in the journal eLife reports a study in which researchers concluded that the proportion of the population previously infected by SARS-CoV-2 (infection-induced seroprevalence) can be estimated using blood donation samples.

20 Dec 2022

SARS-CoV-2 structural proteins trigger periodontal fibrosis

Researchers examined the pathological impacts of the structural components of SARS-CoV-2 on human periodontal cells and tissue to understand the association between coronavirus disease 2019 (COVID-19) and deteriorating oral health.

20 Dec 2022

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Researchers measured the seroprevalence against SARS-CoV-2 in blood donors from the states of Hesse, Lower Saxony, and North Rhine-Westphalia in Germany to determine the incidence of undetected asymptomatic SARS-CoV-2 infections.

20 Dec 2022

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

Researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against SARS-CoV-2.

20 Dec 2022

Spike Protein News and Research

Real-world effectiveness of the bivalent vaccine for preventing COVID-19 hospitalizations in non-hospitalized subjects

Spike protein mutations in Omicron subvariants increase their susceptibility to reductive cleavage of disulfide bonds

Study explores incidence, severity, and long COVID associations of SARS-CoV-2 reinfections

Profound immune escape by SARS-CoV-2 XBB.1 even after 4 vaccine doses

Deletions in the antigenic regions in SARS-CoV-2 increase transmission and immune evasion ability

COVID-19 vaccine potency and breadth improved by nanoparticle-conjugated adjuvants

Free spike proteins in the blood appear to play a role in myocarditis post-COVID mRNA vaccine

Bacterial outer membrane vesicles: utility as vaccines and novel engineering approaches

Effects of hybrid immunity on humoral immune response following COVID mRNA vaccination in a cohort of essential and frontline workers

What is the impact of COVID-19 on the human genetic architecture?

BA.4/BA.5 mutations reduced responsiveness of epitope-specific T cells with original mRNA vaccine

Scientists explore efficacy of small molecule drugs against severe COVID-19 in vitro

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

COVID-19 vaccination protects people with B cell lymphoma and multiple myeloma

T-cell immunity remains effective against SARS-CoV-2 Omicron subvariants

MHRA authorizes the COVID-19 vaccine developed by Sanofi

COVID-19 epidemiology can be estimated using blood donation samples

SARS-CoV-2 structural proteins trigger periodontal fibrosis

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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