Transcription Factors News and Research

RSS

Research findings may explain marked racial disparity in deaths from triple negative breast cancer

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study led by Johns Hopkins Kimmel Cancer Center researchers suggests.

15 Mar 2022

Scientists map key molecular changes during mouse embryogenesis

Scientists have mapped out the key molecular changes that orchestrate how embryonic mouse cells differentiate into the diverse cell types that will ultimately form all the different tissues and organs of the adult animal.

14 Mar 2022

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

9 Mar 2022

New micro-protein supports cell division and proliferation during nutrient scarcity

Researchers from the University of Eastern Finland and the University of Montreal (Canada) have discovered that a micro-protein, which they named Nrs1, supports cell division and proliferation when nutrients are scarce.

4 Mar 2022

UH researcher receives $2 million to develop drugs for traditionally undruggable targets in cancer

With a $2 million recruitment grant from the Cancer Prevention and Research Institute of Texas, a University of Houston researcher is setting up a lab to develop drugs that will work on traditionally undruggable targets in cancer.

2 Mar 2022

The need for a holistic and unbiased approach to develop a more universal vaccine for coronaviruses

Researchers emphasized the need to take on a holistic and unbiased approach to develop a universal vaccine for coronaviruses, including SARS-CoV-2, which is a biomedical priority during the ongoing COVID-19 pandemic.

28 Feb 2022

Melatonin as a safe and potentially life-saving treatment for COVID-19

A new study discusses the possible role of melatonin, an antioxidant and anti-inflammatory agent, in treating COVID-19.

24 Feb 2022

The logic that controls gene regulation in human cells discovered

A research group at the University of Helsinki has discovered the logic that controls gene regulation in human cells. In the future, this new knowledge can be applied to, for example, investigating cancers and other genetic diseases.

21 Feb 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

SARS-CoV-2 ORF6 inhibits mRNA export to favour viral translation and suppress innate signalling

A recent study posted to the bioRxiv* pre-print server investigated the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to inhibit the human immune response against viral infection.

15 Feb 2022

First unbiased proteome scale study expands the number of known transcriptional activators

Also known as transcriptional activators for their ability to induce transcription of genes into RNA messages, these proteins are essential for the cells to function properly. Yet little is known about these proteins, and it wasn't clear how many activators there might be in human cells – until now.

11 Feb 2022

Innate immune specificity is driven by the nervous system, study suggests

Research led by Washington State University scientists supports a novel theory that the innate immune system people are born with can respond differently to specific pathogens.

9 Feb 2022

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Defying conventional epigenomic wisdom, the non-conventional polycomb (PRC)1 variant paradoxically overwhelms the conventional PRC-mediated gene silencing in activated endothelial cells.

8 Feb 2022

Antibody drug improves survival rates in canine prostate cancer model

Dogs are proving to be a far better scientific model for study of prostate cancer than mice, the typical animal used in the lab for this type of research.

8 Feb 2022

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

Researchers from UConn Heath and Yale University have made new advances connecting the evolution of pregnancy and cancer metastasis.

8 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

In a new study, researchers discuss the role of calcium signaling pathways as targets of inhibition in potential new antiviral therapeutic pathways for SARS-CoV-2.

20 Jan 2022

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

In a new study, researchers used bioinformatics tools to explore the biological characteristics of SARS-CoV-2-infected myocardium.

19 Jan 2022

Modular super-enhancer regulates gene expression involved in retina development

Enhancers are regions of DNA that do not code for proteins, but control how genes are expressed. Super-enhancers are clusters of enhancers that together regulate genes with important roles in cell identity.

11 Jan 2022

Transcription Factors News and Research

Research findings may explain marked racial disparity in deaths from triple negative breast cancer

Scientists map key molecular changes during mouse embryogenesis

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

New micro-protein supports cell division and proliferation during nutrient scarcity

UH researcher receives $2 million to develop drugs for traditionally undruggable targets in cancer

The need for a holistic and unbiased approach to develop a more universal vaccine for coronaviruses

Melatonin as a safe and potentially life-saving treatment for COVID-19

The logic that controls gene regulation in human cells discovered

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

SARS-CoV-2 ORF6 inhibits mRNA export to favour viral translation and suppress innate signalling

First unbiased proteome scale study expands the number of known transcriptional activators

Innate immune specificity is driven by the nervous system, study suggests

Researchers identify a bivalent histone-mark switch essential for angiogenesis

Antibody drug improves survival rates in canine prostate cancer model

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

Exploring biological characteristics of SARS-CoV-2-induced myocardial damage

Modular super-enhancer regulates gene expression involved in retina development

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics