Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Scientists find new way to predict obesity-related disease risk

Scientists at Scripps Research and collaborating corporate and academic partners have found a new way to use distinct molecular "signatures" from people with obesity to predict risk of developing diabetes and cardiovascular disease, an advance that could broaden the way doctors and scientists think about diagnosing and treating disease.

12 Oct 2018

Active role of water in a promising biomarker against cancer

The UPV/EHU's Department of Physical Chemistry and the Biofísika Institute have conducted a multidisciplinary study of the Tn antigen that appears in 90% of cancers.

12 Oct 2018

Top journal publishes special issue on deep learning for drug discovery and biomarker development

While the many concepts in artificial intelligence date back to the 20th century, the revolution in deep learning started around 2014-2015 when AI systems started outperforming humans in many tasks ranging from video games and image recognition to autonomous driving.

11 Oct 2018

Chromosomal instability may predict which patients will respond better to colorectal cancer drug

Researchers at RCSI, along with international collaborators within the ANGIOPREDICT research consortium, have discovered that chromosomal instability (where whole human chromosomes or parts of chromosomes are duplicated or deleted) may predict which patients will receive most benefit from a key drug used to treat colorectal cancer (Avastin).

10 Oct 2018

New AUC published for lumbar puncture and spinal fluid analysis in Alzheimer's diagnosis

In preparation for more tools that detect and measure the biology associated with Alzheimer's and other dementias earlier and with more accuracy, an Alzheimer's Association-led Workgroup has published appropriate use criteria for lumbar puncture (spinal tap) and spinal fluid analysis in the diagnosis of Alzheimer's disease.

10 Oct 2018

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

The objective of the research, undertaken in the laboratories of the IBPM, is to develop a model for studying Alzheimer's disease of sporadic origin, in other words, not due to a hereditary genetic mutation.

10 Oct 2018

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Personal Genome Diagnostics, Inc., a leader in cancer genomics and pioneer in liquid biopsy, today reported that its non-invasive, pan-cancer plasma assay is being used in an important new clinical trial, Nivolumab, Ipilimumab in Patients With Hyper Mutated Cancers Detected in Blood, led by the Cancer Research Institute and Canadian Cancer Trials Group.

9 Oct 2018

Gene signature can predict functional recovery after spinal cord injury

Scientists have determined a gene signature that is linked to the severity of spinal cord injury in animals and humans, according to a study in the open-access journal eLife.

5 Oct 2018

Krembil scientists develop potential treatment to stop knee and spine osteoarthritis

Scientists at the Krembil Research Institute have developed a novel therapeutic treatment that has the potential to stop knee and spine osteoarthritis in its tracks.

5 Oct 2018

Presence of high-risk HPV in cervical cancer diagnosis linked to improved prognosis

The presence of the human high-risk papillomavirus in the diagnosis of invasive cervical cancer is linked to a greatly improved prognosis compared with if high-risk HPV cannot be identified in the tumor, researchers at Karolinska Institutet in Sweden report in the scientific journal PLOS Medicine.

3 Oct 2018

Natural compound found in grapes may protect against cancer

Lung cancer is the deadliest form of cancer in the world, and 80% of death are related to smoking. In addition to tobacco control, effective chemoprevention strategies are therefore needed.

3 Oct 2018

Study highlights need for population-specific precision medicine programs in Latin America

Drug safety and effectiveness vary greatly among populations worldwide. Genetics is one of the factors that contribute to variability in drug response.

3 Oct 2018

Natural nanoscopic particles identified as possible diagnostic tool for Alzheimer's

Exosomes are natural nanoscopic particles released by most cell types, and are currently the focus of research because they represent a possible tool for the diagnosis of Alzheimer's. These particles are not so easy to isolate, and nanotechnology may help in this process.

3 Oct 2018

EU countries lack capacity to rapidly move future Alzheimer's treatment into clinical use

The health care systems in some European countries lack the capacity to rapidly move a disease-modifying treatment for Alzheimer's disease from approval into widespread clinical use, which could leave 1 million people without access to transformative care if such a breakthrough occurs, according to a new RAND Corporation study.

1 Oct 2018

Insilico Medicine collaborates with MAWI to develop multi-modal biomarkers of aging

Cardiovascular disease is the leading cause of death and disability in the world. On the eve of the annual World Heart Day, September 29th, Insilico Medicine, Inc., a Rockville-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research announced a research collaboration agreement with MAWI, the next-generation consumer and clinical wearable company, the developer of one of the most accurate clinical-grade ECG wearable devices.

28 Sep 2018

Common biomarker of kidney disease may also indicate COPD

A commonly used biomarker of kidney disease may also indicate lung problems, particularly COPD, or chronic obstructive pulmonary disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

28 Sep 2018

Pfizer announces FDA approval of VIZIMPRO for first-line treatment of EGFR-mutated metastatic NSCLC

Pfizer Inc. today announced that the U.S. Food and Drug Administration has approved VIZIMPRO [vih-ZIM-pro] (dacomitinib), a kinase inhibitor for the first-line treatment of patients with metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletion or exon 21 L858R substitution mutations as detected by an FDA-approved test.

28 Sep 2018

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

FLX Bio, Inc., a clinical-stage, biopharmaceutical company focused on the development of oral small-molecule drugs that target drivers of cancer and other immune-related disorders, today announced that the first patient has been treated in its Phase 1/2 clinical trial of FLX475 in patients with various advanced cancers. FLX475 is an oral, small molecule CCR4 antagonist that selectively inhibits migration of regulatory T cells into the tumor microenvironment.

27 Sep 2018

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today positive topline results from the interim analysis of the ENVISION Phase 3 Study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 for the treatment of acute hepatic porphyria.

27 Sep 2018

VCU researchers to study how a gene could influence cognitive decline during chemotherapy

With the help of a $2.1 million grant, Virginia Commonwealth University School of Nursing researchers will study how a gene that regulates estrogen and neurotransmitter levels could be tied to cognitive decline in patients undergoing chemotherapy for breast and endometrial cancers.

27 Sep 2018

Biomarker News and Research

Further Reading

Scientists find new way to predict obesity-related disease risk

Active role of water in a promising biomarker against cancer

Top journal publishes special issue on deep learning for drug discovery and biomarker development

Chromosomal instability may predict which patients will respond better to colorectal cancer drug

New AUC published for lumbar puncture and spinal fluid analysis in Alzheimer's diagnosis

Scientists identify new biomarker for Alzheimer's disease of sporadic origin

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Gene signature can predict functional recovery after spinal cord injury

Krembil scientists develop potential treatment to stop knee and spine osteoarthritis

Presence of high-risk HPV in cervical cancer diagnosis linked to improved prognosis

Natural compound found in grapes may protect against cancer

Study highlights need for population-specific precision medicine programs in Latin America

Natural nanoscopic particles identified as possible diagnostic tool for Alzheimer's

EU countries lack capacity to rapidly move future Alzheimer's treatment into clinical use

Insilico Medicine collaborates with MAWI to develop multi-modal biomarkers of aging

Common biomarker of kidney disease may also indicate COPD

Pfizer announces FDA approval of VIZIMPRO for first-line treatment of EGFR-mutated metastatic NSCLC

FLX Bio treats first patient in its Phase 1/2 clinical trial of FLX475 for treating various advanced cancers

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

VCU researchers to study how a gene could influence cognitive decline during chemotherapy

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