Clinical Trial News and Research

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Daily statin medication could improve cardiovascular outcomes in people with HIV

A National Institutes of Health clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV in the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population.

11 Apr 2023

Personalized drug therapy for hypertension may provide maximum benefit

Patients treated with blood pressure-lowering drugs can experience much greater improvements from a change of medication than from doubling the dose of their current medication.

11 Apr 2023

A call for a universal definition of post-COVID-19 condition (PCC)

Researchers assessed the published definitions of the post-coronavirus disease 2019 condition.

10 Apr 2023

Leveraging cell self-destruction to treat glioblastoma tumors

Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies.

7 Apr 2023

Improving cancer awareness among the rural American Indian communities

Phyllis Nassi, MSW, associate director of research and science, special populations, directs the American Indian program at Huntsman Cancer Institute and recently received the 2023 American Association for Cancer Research Distinguished Public Service Award for Exceptional Leadership in Cancer Advocacy.

6 Apr 2023

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

A new drug, a monoclonal antibody known as enoblituzumab, is safe in men with aggressive prostate cancer and may induce clinical activity against cancer throughout the body, according to a phase 2 study led by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

New machine learning model estimates optimal treatment timing for sepsis

A new machine learning model that estimates optimal treatment timing for sepsis could pave the way for support tools that help physicians personalize treatment decisions at the patient bedside, researchers say.

6 Apr 2023

Fasting diet could be the key to reducing the risk of type 2 diabetes

A fasting diet which focuses on eating early in the day could be the key to reducing the risk of developing type 2 diabetes.

6 Apr 2023

Intramuscular injection of TXA may be a potential alternative to reduce obstetric bleeding

Intramuscular administration of tranexamic acid (TXA), a drug used to target severe bleeding after childbirth, is safe and quickly reaches therapeutic concentrations in pregnant women, according to a study involving researchers from the London School of Hygiene & Tropical Medicine.

6 Apr 2023

How does increased family mealtime duration affect children's fruit and vegetable intake?

Researchers evaluated the effect of extending the family mealtime duration on fruit and vegetable intake in children.

6 Apr 2023

Study reviews the diagnosis and treatment of acute myocarditis

Scientists have recently reviewed and summarized the evidence regarding diagnosing and treating acute myocarditis.

6 Apr 2023

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researchers analyzed data on the association between intestinal microbiome dysbiosis and rheumatoid arthritis.

6 Apr 2023

Trial compares the ability of AI and sonographer in assessing cardiac function

Who can assess and diagnose cardiac function best after reading an echocardiogram: artificial intelligence (AI) or a sonographer?

5 Apr 2023

Promising new combination of drugs identified to treat juvenile myelomonocytic leukemia

Indiana University School of Medicine researchers have identified a promising new combination of drugs to treat juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer that affects children.

5 Apr 2023

Study reveals the potential cost savings of a therapy for babies displaying early signs of autism

New research evaluating the potential cost savings of a therapy for babies displaying early autism signs has predicted a three dollar return to Australia's National Disability Insurance Scheme (NDIS) for every dollar invested in therapy.

5 Apr 2023

What effect do nuts have on gastrointestinal health?

Researchers presented an overview of the latest research on the impact of nut intake on gastrointestinal health.

4 Apr 2023

New approach to primary palliative care increases uptake of advance care planning among patients with advanced cancer

New research in the April 2023 issue of JNCCN - Journal of the National Comprehensive Cancer Network finds that specially trained oncology infusion room nurses can improve advance care planning (ACP) for patients with advanced cancer.

4 Apr 2023

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

A clinical trial at the National Institutes of Health found that a medication, denosumab, significantly reduced abnormal bone turnover in adults with fibrous dysplasia, a rare disease marked by weak and misshapen bones.

4 Apr 2023

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.

4 Apr 2023

Clinical Trial News and Research

Daily statin medication could improve cardiovascular outcomes in people with HIV

Personalized drug therapy for hypertension may provide maximum benefit

A call for a universal definition of post-COVID-19 condition (PCC)

Leveraging cell self-destruction to treat glioblastoma tumors

Improving cancer awareness among the rural American Indian communities

Phase 2 study shows safety and efficacy of new drug in men with high-risk prostate cancers

Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

New machine learning model estimates optimal treatment timing for sepsis

Fasting diet could be the key to reducing the risk of type 2 diabetes

Intramuscular injection of TXA may be a potential alternative to reduce obstetric bleeding

How does increased family mealtime duration affect children's fruit and vegetable intake?

Study reviews the diagnosis and treatment of acute myocarditis

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Trial compares the ability of AI and sonographer in assessing cardiac function

Promising new combination of drugs identified to treat juvenile myelomonocytic leukemia

Study reveals the potential cost savings of a therapy for babies displaying early signs of autism

What effect do nuts have on gastrointestinal health?

New approach to primary palliative care increases uptake of advance care planning among patients with advanced cancer

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

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