Therapeutics News and Research

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The role of ARF6 in SARS-CoV-2 endocytosis and infection

Researchers assessed the role of adenoside diphosphate (ADP)-ribosylation factor 6 (ARF6) in SARS-CoV-2 infection.

14 Jun 2022

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

Orbit Discovery Ltd., (“Orbit”) a privately held biopharmaceutical company focused on discovering candidate peptide therapeutics harnessing proprietary affinity and cell-based functional screening platforms, has been awarded a Smart grant by Innovate UK, the UK’s innovation agency.

From Orbit Discovery 14 Jun 2022

Researchers localize specific brain circuit mediating addiction remission

In the United States, substance use disorders are a leading cause of death among young people. Treatments such as deep brain stimulation hold promise for helping people overcome addiction, but many questions remain about what brain areas should be targeted.

13 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

The physiological relevance and effects of probable in vivo transformation of CBD to delta9-THC in humans

Researchers reviewed studies on the probable conversion of orally administered cannabidiol (CBD) to delta9-tetrahydrocannabinol (delta9-THC or THC) in humans.

10 Jun 2022

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A drug used to target IDH1 mutations in select cancers also appears to inhibit the wild-type form of the enzyme, under certain conditions.

9 Jun 2022

A comparison of SARS-CoV-2 and influenza cytokine storms

In a recent study published in the Journal of Interferon & Cytokine Research, researchers compared the cytokine storms of pandemic influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

9 Jun 2022

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Of the three groups of rotavirus that cause gastroenteritis in people, called groups A, B and C, groups A and C affect mostly children and are the best characterized.

9 Jun 2022

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

A new research describes how highly proliferative leukemia cells end up becoming normal cells that no longer multiply, by changing the chemical modifications -the so-called epigenetics- of a type of its genetic material: the messenger RNA.

9 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

Curia and Replicate Bioscience Enter Strategic Collaboration to Create Groundbreaking Development Platform for Self-Replicating RNA (srRNA)

From Curia 9 Jun 2022

Study describes one of the first entirely new drug delivery microencapsulation approaches in decades

A new study from the University of Michigan describes one of the first entirely new drug delivery microencapsulation approaches in decades.

8 Jun 2022

Study on the underlying biology of long COVID

In a recent article published in the Science Translational Medicine journal, researchers analyzed prolonged and unique implications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans and hamsters following recovery.

8 Jun 2022

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation exposure.

8 Jun 2022

Zoonotic origins of seasonal human coronaviruses

In a recent study posted to the bioRxiv* preprint server, investigators analyzed the evolution and origin of seasonal human coronaviruses (sHCoVs).

8 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

Molecule in mosquito saliva can be a potential new target for halting deadly diseases

A molecule in mosquito spit has been identified as a potential new target for vaccination against a range of diseases for which there is no protection or medicine.

8 Jun 2022

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Parkinson's disease is best-known as a disorder of movement. Patients often experience tremors, loss of balance, and difficulty initiating movement. The disease also has lesser-known symptoms that are nonmotor, including depression.

8 Jun 2022

Researchers develop new chemical-only process for creating customized mRNA vaccines

Researchers at Nagoya University in Japan have developed a new chemical-only process that may represent an important breakthrough in creating customized mRNA vaccines for a variety of diseases and allow for the inexpensive preparation of mRNA in large quantities.

8 Jun 2022

Therapeutics News and Research

The role of ARF6 in SARS-CoV-2 endocytosis and infection

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

Researchers localize specific brain circuit mediating addiction remission

Deciphering the structure of nuclear pore complex piece by piece

The physiological relevance and effects of probable in vivo transformation of CBD to delta9-THC in humans

Research reveals why many cancers are vulnerable to FDA-approved IDH1 inhibitors

A comparison of SARS-CoV-2 and influenza cytokine storms

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Research reveals how highly proliferative leukemia cells turn into normal harmless ones

Study shines new light on the role of key Parkinson’s disease protein

Curia and Replicate Bioscience Enter Strategic Collaboration to Create Groundbreaking Development Platform for Self-Replicating RNA (srRNA)

Study describes one of the first entirely new drug delivery microencapsulation approaches in decades

Study on the underlying biology of long COVID

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Zoonotic origins of seasonal human coronaviruses

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Molecule in mosquito saliva can be a potential new target for halting deadly diseases

Targeting thalamic circuits could reverse Parkinson’s symptoms in mice

Researchers develop new chemical-only process for creating customized mRNA vaccines

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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