Clinical Trial News and Research

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Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Patients with early relapsed or refractory large B-cell lymphoma had significantly improved overall survival when treated with the chimeric antigen receptor (CAR) T cell therapy axicabtagene ciloleucel (axi-cel) when compared to the current standard-of-care chemoimmunotherapy, according to results of the Phase III ZUMA-7 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

5 Jun 2023

Study provides a treasure trove of information on molecular biology of the immune system

Researchers at Sanford Burnham Prebys, collaborating with scientists from Eli Lilly and Company, have revealed the structure and function of a drug called LY3361237, which can reduce the harmful activity of the immune system to help treat autoimmune diseases.

5 Jun 2023

Improving prostate cancer screening: accounting for genetic determinants of PSA variation

Researchers conducted a genome-wide analysis of prostate-specific antigen (PSA) levels of men without prostate cancer.

5 Jun 2023

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

At the 2023 American Society for Clinical Oncology Annual Meeting—to be held June 2-6 in Chicago, Illinois—Fred Hutchinson Cancer Center experts will present research spanning survivorship, advances in treatments and clinical trials, how access to cancer care affects outcomes, integrative medicine and more.

5 Jun 2023

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

In an international study co-led by UCLA, scientists have shown that a new targeted therapy drug can extend the amount of time people with a subtype of glioma are on treatment without their cancer worsening.

4 Jun 2023

SWOG Cancer Research Network clinical trial reveals potential new therapy for Stage 3 or 4 classic Hodgkin lymphoma

A Phase 3 trial has demonstrated that patients with advanced stage (3 or 4) classic Hodgkin lymphoma who underwent initial treatment with nivolumab, a PD-1 checkpoint inhibitor, and AVD chemotherapy (N-AVD) had a significantly lower risk of their cancer getting worse than patients treated with brentuximab vedotin, a monoclonal antibody, and AVD (BV-AVD) a year after starting treatment.

4 Jun 2023

Mediterranean diet in pregnancy: A recipe for reduced stress and improved sleep

A Mediterranean diet intervention during pregnancy reduces maternal stress and anxiety levels, improves sleep quality, and increases the cortisone/cortisol ratio. These findings highlight the positive impact of dietary changes on maternal well-being during gestation.

4 Jun 2023

Study of immunotherapy for brain cancer metastases shows promising results

In a phase 2 clinical trial of the immune checkpoint inhibitor pembrolizumab, investigators found that 42 percent of patients with metastatic brain cancer benefited from the therapy, with seven patients in the trial surviving longer than two years.

2 Jun 2023

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Lupus Therapeutics announced the start of a collaboration to conduct three Phase 3 clinical trials testing an investigational therapeutic ianalumab for systemic lupus erythematosus and lupus nephritis.

2 Jun 2023

Experts voice the need for comparing traditional clinical trials to decentralized trials

There's one question that Hollings Cancer Center researcher Jennifer Dahne, Ph.D., co-director of the remote and virtual trials program at the South Carolina Clinical & Translational Research Institute, hears more than any other as she consults with clinical researchers about how to set up remote trials, also known as decentralized trials. Will these trials overcome the barriers that make it difficult for minority and underserved populations to participate in clinical trials? It's also a question she often discusses with her peers at other academic medical centers that are also home to Clinical and Translational Science Award hubs.

2 Jun 2023

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

The results of a new clinical trial suggest that the first drug therapy to slow the progression of nearsightedness in kids could be on the horizon.

1 Jun 2023

NCI launches new initiative to test new drug combinations that target specific tumor alterations

The National Cancer Institute (NCI) has launched a large precision medicine cancer initiative to test the effectiveness of treating adults and children with new drug combinations that target specific tumor alterations.

1 Jun 2023

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a fatal motor neuron disease that causes people to gradually lose control of their muscles.

1 Jun 2023

Can adherence to the Mediterranean diet reduce gestational stress and anxiety in pregnant women?

Researchers investigated the influence of structured Mediterranean diet intervention on the anxiety and stress levels.

1 Jun 2023

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

Researchers explored strategies for enhancing compliance with a Mediterranean ketogenic nutrition program among older individuals.

1 Jun 2023

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) occurs in 30% of hospitalized cirrhosis patients, leading to over one million deaths worldwide each year.

31 May 2023

First-in-human clinical trial of liver dialysis device successfully completed

The first successful in-patient trial of liver dialysis* has been completed by researchers from UCL, the Royal Free Hospital, UCL spin-out Yaqrit and their collaborators.

31 May 2023

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

Chemotherapy-induced peripheral neuropathy (CIPN) – nerve pain, tingling, or numbness in the hands or feet – is a common side effect of certain cancer treatments, including two drugs frequently used to treat cancer – the taxanes paclitaxel and docetaxel.

31 May 2023

A simple tweak to first meal of the day may benefit people with Type 2 diabetes

An international team, led by UBC Okanagan researchers, suggests a simple tweak to the first meal of the day might help people living with Type 2 diabetes (T2D) better control their blood sugar levels.

31 May 2023

Extended lymphadenectomy for locally advanced bladder cancer provides no patient benefit

An extended lymphadenectomy – removal of additional lymph nodes beyond the extent of the standard procedure – in patients undergoing radical cystectomy (removal of bladder and nearby tissues) because of clinically localized muscle-invasive bladder cancer provides no patient benefit as measured by disease-free survival or overall survival times.

30 May 2023

Clinical Trial News and Research

Phase III ZUMA-7 trial: Patients with high-risk large B-cell lymphoma lived longer with axi-cel

Study provides a treasure trove of information on molecular biology of the immune system

Improving prostate cancer screening: accounting for genetic determinants of PSA variation

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

Study suggests possible new treatment option for people with slow-growing but deadly brain tumor

SWOG Cancer Research Network clinical trial reveals potential new therapy for Stage 3 or 4 classic Hodgkin lymphoma

Mediterranean diet in pregnancy: A recipe for reduced stress and improved sleep

Study of immunotherapy for brain cancer metastases shows promising results

Lupus Therapeutics announces three Phase 3 clinical trials testing new therapies for SLE and lupus nephritis

Experts voice the need for comparing traditional clinical trials to decentralized trials

Eye drops to slow the progression of nearsightedness in kids could be on the horizon

NCI launches new initiative to test new drug combinations that target specific tumor alterations

Parkinson's disease drug ropinirole is safe and tolerable for ALS patients, early clinical trial shows

Can adherence to the Mediterranean diet reduce gestational stress and anxiety in pregnant women?

Pilot study reveals effective approach to boost adherence to Mediterranean ketogenic diet for memory concerns in older adults

DIALIVE device may be a disease-modifying therapy for patients with acute-on-chronic liver failure

First-in-human clinical trial of liver dialysis device successfully completed

Breast cancer patients experience more severe CIPN symptoms with paclitaxel

A simple tweak to first meal of the day may benefit people with Type 2 diabetes

Extended lymphadenectomy for locally advanced bladder cancer provides no patient benefit

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