Clinical Trial News and Research

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Novel immunotherapy-based approach for low-grade lymphomatoid granulomatosis improves patient survival

Results from a clinical trial conducted by researchers at the National Institutes of Health (NIH) show that people with low-grade lymphomatoid granulomatosis who are treated with interferon alfa-2b, a type of immunotherapy, can live for decades after diagnosis.

4 Apr 2023

Live attenuated nasal vaccine elicits superior immunity to SARS-CoV-2 variants in hamsters

Since the beginning of the COVID-19 pandemic, researchers have been working on mucosal vaccines that can be administered through the nose.

4 Apr 2023

Clinical trial findings may be a game changer in the treatment of pediatric Crohn's disease

Crohn's disease is a lifelong inflammatory bowel disease (IBD) that is characterized by swelling in the lining of the digestive tract, causing severe diarrhea, abdominal pain, and rectal bleeding.

3 Apr 2023

Study investigates vitamin C's effectiveness in treating gout and hyperuricemia

Scientists at the University of Minnesota, USA, have initiated a study entitled “the Hmong Microbiome and Gout, Obesity, Vitamin C (HMANGO-C) study” to determine the effect of vitamin C supplementation on serum urate levels in Hmong adults with or without gout. Hmong (pronounced mung) is a racial group originally from the Southwest of China.

3 Apr 2023

Online "e-health" program helps people with chronic pain reduce opioids and pain intensity

An online "e-health" program helped more people with chronic pain reduce their opioid medications and pain intensity than a control group that had only regular treatment in a recent clinical study.

3 Apr 2023

Study demonstrates an effective technology-driven alternative to psychiatric medications for social anxiety

A new clinical trial conducted at Tel Aviv University has demonstrated an effective technology-driven alternative to psychiatric medications for people with social anxiety.

3 Apr 2023

Targeting bad bacteria and the immune system in isolation may help fight deadly infections

Twenty to 50 per cent of all critically ill patients contract potentially deadly infections during their stay in the intensive care unit or in hospital after being in the ICU – markedly increasing the risk of death.

31 Mar 2023

Social rank affects how an individual responds to chronic psychosocial stress

Can an individual's social status have an impact on their level of stress? Researchers at Tulane University put that question to the test and believe that social rank, particularly in females, does indeed affect the stress response.

31 Mar 2023

Vedolizumab found to be effective for the treatment of chronic pouchitis after colectomy

12% of people with ulcerative colitis need surgery to have their colon removed (colectomy). Most of those have an ileo-anal pouch surgically constructed from their small bowel, which means that they don't have to live with a stoma bag.

31 Mar 2023

What is the effect of supplementing raisins on improving cognitive performance, cardiovascular risk factors, and markers of inflammation?

Researchers devised a protocol to examine the effect of raisin supplementation on cognitive function in older adults.

31 Mar 2023

Innovative treatment reduces the risk of amputation for patients with vascular disease

More than 75% of patients facing amputation from the most severe form of peripheral artery disease were able to keep their limb after an innovative treatment as part of a multicenter study published in the New England Journal of Medicine.

30 Mar 2023

Buprenorphine can be safely started in the ER without triggering withdrawal even for people using stronger opioids

Results from a multi-site clinical trial supported by the National Institutes of Health showed that less than 1% of people with opioid use disorder whose drug use includes fentanyl experienced withdrawal when starting buprenorphine in the emergency department.

30 Mar 2023

Hypertension in childhood often leads to high blood pressure in adulthood

High blood pressure in children is not uncommon, and research shows it may lead to high blood pressure in adulthood, as well as problems with the heart, blood vessels and kidneys, according to a new scientific statement from the American Heart Association published today in the Association's Hypertension journal.

30 Mar 2023

Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

Study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation

A newly published study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation.

30 Mar 2023

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Researchers identified an interleukin 6 dependent alternative pathway as a therapeutic strategy against coronavirus disease 2019.

30 Mar 2023

Study predicts the country-specific impact of maternal vaccination against respiratory syncytial virus

Researchers developed a mathematical model to predict the potential impact of maternal vaccination on RSV-related childhood mortality.

30 Mar 2023

The decision-making process for the launch of trials for COVID-19 repurposed antivirals

Researchers reviewed the decision-making process for performing randomized clinical trials for three drugs under consideration for repurposing for COVID-19 treatment: remdesivir, molnupiravir, and tenofovir disoproxil fumarate.

30 Mar 2023

Lab-made antibodies may be able to cure people infected with yellow fever

New research from Oregon Health & Science University and collaborators indicates lab-made antibodies may be able to cure people infected with yellow fever, a virus for which there is no treatment.

29 Mar 2023

Drugs to activate STING could help prevent cancer metastasis

A team of scientists at the Sloan Kettering Institute have identified the STING cellular signaling pathway as a key player in keeping dormant cancer cells from progressing into aggressive tumors months, or even years, after they've escaped from a primary tumor.

29 Mar 2023

Clinical Trial News and Research

Novel immunotherapy-based approach for low-grade lymphomatoid granulomatosis improves patient survival

Live attenuated nasal vaccine elicits superior immunity to SARS-CoV-2 variants in hamsters

Clinical trial findings may be a game changer in the treatment of pediatric Crohn's disease

Study investigates vitamin C's effectiveness in treating gout and hyperuricemia

Online "e-health" program helps people with chronic pain reduce opioids and pain intensity

Study demonstrates an effective technology-driven alternative to psychiatric medications for social anxiety

Targeting bad bacteria and the immune system in isolation may help fight deadly infections

Social rank affects how an individual responds to chronic psychosocial stress

Vedolizumab found to be effective for the treatment of chronic pouchitis after colectomy

What is the effect of supplementing raisins on improving cognitive performance, cardiovascular risk factors, and markers of inflammation?

Innovative treatment reduces the risk of amputation for patients with vascular disease

Buprenorphine can be safely started in the ER without triggering withdrawal even for people using stronger opioids

Hypertension in childhood often leads to high blood pressure in adulthood

Riboswitch may be the key to advance gene therapy, regenerative medicine

Study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Study predicts the country-specific impact of maternal vaccination against respiratory syncytial virus

The decision-making process for the launch of trials for COVID-19 repurposed antivirals

Lab-made antibodies may be able to cure people infected with yellow fever

Drugs to activate STING could help prevent cancer metastasis

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