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New findings pave way for novel, improved drugs to treat psychiatric disorders

Researchers at Columbia University Irving Medical Center have found new evidence of how certain transport proteins are working at the molecular level, paving the way for new, improved drugs to treat psychiatric disorders.

9 Aug 2018

New CAR T-cell immunotherapy trial targets solid tumors

Seattle Children's has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

7 Aug 2018

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

A biochemistry instructor curious about an enzyme discovered in the damaged neurons of people with multiple sclerosis made a leap toward a potential cure for countless neurodegenerative ills.

7 Aug 2018

Cocaine relapse is reduced in preclinical model with BDNF administration

Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina in an article published online in June 2018 by Addiction Biology.

3 Aug 2018

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

AstraZeneca and Merck, known as MSD outside the U.S. and Canada, today announced that the European Medicines Agency (EMA) has granted orphan designation to selumetinib, a MEK 1/2 inhibitor, for the treatment of neurofibromatosis type 1 (NF1).

3 Aug 2018

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Johns Hopkins Medicine scientists say they have found new evidence in lab-grown mouse brain cells, called astrocytes, that one root of Alzheimer's disease may be a simple imbalance in acid-alkaline - or pH - chemistry inside endosomes, the nutrient and chemical cargo shuttles in cells.

2 Aug 2018

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Regenacy Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company developing breakthrough treatments for diabetic and other peripheral neuropathies, today announced a collaboration with the Charcot-Marie-Tooth Association, a registered non-profit organization serving the hereditary neuropathy patient community, to validate the role of HDAC6 in multiple forms of Charcot-Marie-Tooth disease and evaluate the efficacy of ricolinostat, a selective HDAC6 inhibitor, in animal models.

2 Aug 2018

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

A protein known to drive nerve cell survival in the brain and spinal cord might also protect failing hearts in children and young adults with Duchenne muscular dystrophy, according to preliminary research presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions, a premier global exchange of the latest advances in basic cardiovascular science.

2 Aug 2018

Acetyl-L-carnitine chemical in blood connected to depression

A group of researchers from Stanford in collaboration with other universities have found that in humans a low level of acetyl-L-carnitine or L-acetyle carnitine in blood could be a predictor of the duration and severity of depression.

1 Aug 2018

Glaucoma Research Foundation-funded research makes breakthrough in treatment of glaucoma

Glaucoma Research Foundation, a national non-profit organization dedicated to finding a cure for glaucoma, today announced a team of neuroscience researchers, led by Adriana Di Polo, PhD, at University of Montreal, have made a major breakthrough in the treatment of glaucoma.

31 Jul 2018

Alzheimer’s-in-a-dish model made better with microfluidic system

Researchers from Massachusetts have used a microfluidic device to incorporate neuroinflammation into the Alzheimer's-in-a-dish model for drug discovery.

31 Jul 2018

Researchers describe strategy used by Oropouche virus to replicate in human cells

The strategy used by the Oropouche virus to replicate in human cells has been described for the first time by researchers at the University of São Paulo in Brazil and international collaborators in an article published in the journal PLOS Pathogens.

31 Jul 2018

Computational platform predicts how to convert one cell type into another

Researchers have developed a computational platform that predicts how one subtype of cells can be converted into another subtype.

30 Jul 2018

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the Committee for Medicinal Products for Human Use has adopted a Positive Opinion recommending marketing authorization of patisiran for the treatment of hereditary transthyretin-mediated amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

27 Jul 2018

Targeting mossy cells may offer new strategy for treating brain disorders

A small population of brain cells deep in a memory-making region of the brain controls the production of new neurons and may have a role in common brain disorders, according to a study from scientists at the University of North Carolina School of Medicine.

27 Jul 2018

Researchers investigate how afferent nerves that sprout from the ectopic ear reach the brain

In vertebrates, the inner ear develops from the otic placode, a group of cells found in a specific region on the surface of the growing embryo.

27 Jul 2018

Discovery of two molecules could pave way for new drugs to treat traumatic brain injury

After 10 years of research, a Rutgers-led team of scientists has identified two molecules that protect nerve cells after a traumatic brain injury and could lead to new drug treatments.

27 Jul 2018

Experts highlight the need to avoid overdiagnosis and 'excessive' treatment of thyroid cancer

More Americans are being diagnosed with thyroid cancer than ever before--over the past 25 years its incidence has tripled.

26 Jul 2018

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Certara, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, announced today that Clinical Pharmacology & Therapeutics has published its "Letter to the Editor" describing the important role that quantitative systems pharmacology can play in defining dosing criteria for first-in-human clinical trials, together with the European Medicines Agency's response.

26 Jul 2018

Cutting-edge laboratory technique recapitulates brain development more accurately than ever

A cutting-edge laboratory technique that turns human stem cells into brain-like tissue now recapitulates human brain development more accurately than ever, according to a new study from Case Western Reserve University School of Medicine.

26 Jul 2018

Nerve News and Research

New findings pave way for novel, improved drugs to treat psychiatric disorders

New CAR T-cell immunotherapy trial targets solid tumors

Study: HDAC1 enzyme modifies molecular motor that drives neuron death

Cocaine relapse is reduced in preclinical model with BDNF administration

EMA grants orphan designation to selumetinib for treatment of neurofibromatosis type 1

Simple pH imbalance could be a root of Alzheimer’s disease, mouse study shows

Regenacy Pharmaceuticals partners with CMTA to advance ricolinostat for treating hereditary neuropathy

Protein known to drive nerve cell survival may protect children from Duchenne cardiomyopathy

Acetyl-L-carnitine chemical in blood connected to depression

Glaucoma Research Foundation-funded research makes breakthrough in treatment of glaucoma

Alzheimer’s-in-a-dish model made better with microfluidic system

Researchers describe strategy used by Oropouche virus to replicate in human cells

Computational platform predicts how to convert one cell type into another

Alnylam’s patisiran receives positive opinion from CHMP for treating hATTR amyloidosis

Targeting mossy cells may offer new strategy for treating brain disorders

Researchers investigate how afferent nerves that sprout from the ectopic ear reach the brain

Discovery of two molecules could pave way for new drugs to treat traumatic brain injury

Experts highlight the need to avoid overdiagnosis and 'excessive' treatment of thyroid cancer

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Cutting-edge laboratory technique recapitulates brain development more accurately than ever

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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