Enzyme News and Research

RSS

Machine learning method for determining impact of mutations in the SARS-CoV-2 RBD on binding and antibody escape

Deep mutational learning (DML) is a technique developed by researchers from multiple institutions that combines experimental yeast display screening of RBD mutagenesis libraries with deep sequencing and machine learning.

14 Dec 2021

CRISPR-Cas enzyme-based diagnostics to detect SARS-CoV-2 infection

A recent review in the journal Life provided a detailed description of CRISPR-Cas-based diagnostic techniques to identify severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but also emphasized the potential use of this technology towards developing effective molecular diagnostic platforms for any future pandemic.

13 Dec 2021

Combination treatment can provide long remissions for young patients with chronic lymphocytic leukemia

Young patients with chronic lymphocytic leukemia (CLL) can enjoy long remissions on the drug ibrutinib, but must stay on it indefinitely to keep the cancer in remission.

13 Dec 2021

Iota-carrageenan inhibits replication of SARS-CoV-2 VOCs

Scientists have recently reported the efficacy of carrageenan against both the SARS-CoV-2 original strain as well as the Alpha, Beta, Gamma, and Delta VOCs.

13 Dec 2021

Novel assay using finger-prick samples provides COVID-19 vaccine efficacy data

Researchers estimate vaccine efficacy over a period post-vaccination using quantitative antibody assay on finger-prick blood samples.

13 Dec 2021

Using cannabis alongside other drugs may lead to harmful drug-drug interactions

Using cannabis alongside other drugs may come with a significant risk of harmful drug-drug interactions, new research by scientists at Washington State University suggests.

13 Dec 2021

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new study shows that the ACE2 and RBD of coronavirus spike fragments have different binding strengths and dissociation rates when they are glycosylated and non-glycosylated.

13 Dec 2021

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

A review assessed the impact of "hot" vs. "cold" immune/tumor environments (and associated therapies) on susceptibility and disease course in subjects with these two types of tumors and infected with SARS-CoV-2 to decipher the mechanisms that drive these adverse outcomes in COVID-19 infected cancer patients.

13 Dec 2021

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

Researchers have been investigating the immune response in previously infected healthcare workers after they receive these vaccines.

13 Dec 2021

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

...

12 Dec 2021

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

A new study demonstrates lethal infection of the olfactory epithelium in a mouse model that could help understand the mechanisms of COVID-19.

12 Dec 2021

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

A new study reports a method using four PCR tests to distinguish infection with the Omicron variant from that caused by other variants.

12 Dec 2021

New tool to help map immune escape with SARS-CoV-2 mutations

A new study discusses a computational program that can be used to substitute for actual experimental evidence of the biologic impact of new mutations.

12 Dec 2021

Former diabetes drug may help in the treatment of breast cancer, study shows

Findings from a new study led by Yale Cancer Center show the small molecule inhibitor drug, PF05175157, originally developed to treat diabetes by Pfizer, may help in the treatment of breast cancer.

12 Dec 2021

Study finds mutational changes in Omicron variant likely increase transmissibility

A new study presented evidence for a large number of mutational changes in the Omicron variant which will likely increase its transmissibility and significantly decrease the neutralization capacity of monoclonal antibodies, leading to a decline in vaccine efficacy.

10 Dec 2021

Enzyme News and Research

Machine learning method for determining impact of mutations in the SARS-CoV-2 RBD on binding and antibody escape

CRISPR-Cas enzyme-based diagnostics to detect SARS-CoV-2 infection

Combination treatment can provide long remissions for young patients with chronic lymphocytic leukemia

Iota-carrageenan inhibits replication of SARS-CoV-2 VOCs

Novel assay using finger-prick samples provides COVID-19 vaccine efficacy data

Using cannabis alongside other drugs may lead to harmful drug-drug interactions

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

New tool to help map immune escape with SARS-CoV-2 mutations

Former diabetes drug may help in the treatment of breast cancer, study shows

Study finds mutational changes in Omicron variant likely increase transmissibility

Mutational landscape of SARS-CoV-2 Omicron variant

Screening FDA-approved compounds shown to possess antiviral or antimicrobial activity for SARS-CoV-2 inhibition

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Novel waveform-based approach to determine the propensity of betacoronaviruses to infect humans

Biochemistry eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo