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New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments.

3 Jun 2021

Nanopore sequencing contradicts human genome integration of SARS-CoV-2

Now a new preprint research paper posted to the bioRxiv* server dismisses the possibility, raised by that study, that the virus inserts its genetic material into the host cell’s genome.

2 Jun 2021

Could certain genes be associated with a loss of smell in some COVID-19 patients?

Researchers at the 23andMe COVID-19 Team, who help search for genetic links associated with the severity of COVID-19, found that the genes UGT2A1 and UGT2A2 may be associated with the loss of smell in those infected with SARS-CoV-2.

2 Jun 2021

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

SWOG researchers to present practice-changing research at virtual ASCO 2021

"SWOG always brings an impressive portfolio of work to the ASCO annual meeting," said SWOG Chair Charles D. Blanke, MD, "and this year I'm particularly excited about the research our investigators are presenting because it includes results that are likely to be practice-changing."

1 Jun 2021

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Moffitt Cancer Center, a national leader in cancer care and research and the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, is presenting new data from dozens of clinical research studies at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, the world's largest clinical cancer research meeting.

1 Jun 2021

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

A series of autopsies performed in an infectious disease hospital in the Brazilian Amazon reveals that infections by the Histoplasma fungus are a major cause of death in people with HIV.

1 Jun 2021

Researchers develop new method for sequencing single cells in an efficient manner

RNA sequencing is a powerful technology for studying cells and diseases. In particular, single-cell RNA sequencing helps uncover the heterogeneity and diversity of our body.

1 Jun 2021

Ethnic diversity in genetic study identifies more genomic regions linked to type 2 diabetes-related traits

By ensuring ethnic diversity in a largescale genetic study, an international team of researchers, including a University of Massachusetts Amherst genetic epidemiologist, has identified more regions of the genome linked to type 2 diabetes-related traits.

1 Jun 2021

New method helps identify rare genetic disease that affects brain development

Rare disease experts detail the first results of an unprecedented collaboration to diagnose people living with unsolved cases of rare diseases across Europe.

1 Jun 2021

Ethnic diversity in genetic study of glycemic traits yields better results

By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone.

31 May 2021

Expanding genomic research into different ancestries yields more and better results

Today The Lundquist Institute announced that its investigators contributed data from several studies, including data on Hispanics, African-Americans and East Asians, to the international MAGIC collaboration, composed of more than 400 global academics, who conducted a genome-wide association meta-analysis led by the University of Exeter.

31 May 2021

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

An interesting new study by researchers at the University of Portsmouth, UK, describes the use of a mathematical method to sequence genomes based on information theory. The method offers an alternative to clinical techniques, allowing mutations to be detected and possibly even predicted. In this way, it opens new research opportunities in bioinformatics and genetics.

31 May 2021

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 has a single-stranded RNA genome encoding both structural and non-structural proteins. Of these, the latter is known to play a variety of roles in viral replication and the assembly of new viral particles, as well as in suppressing cellular immune responses. A new study reports the activity of one such protein, the non-structural protein 14 (NSP14), which activates the inflammatory mediator NF-κB to trigger intense inflammation.

31 May 2021

SARS-CoV-2 genome mutations display convergent evolution indicating strong adaptive advantages

A recent report by a team of researchers focused on the extent of convergent evolution in the SARS-CoV-2 spike (S) protein. The report confirms that top SARS-CoV-2 lineages of concern have the most convergent spike protein mutations. This indicates their fundamental adaptive advantage.

31 May 2021

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Researchers at the Southern University of Science and Technology in China revealed rapid and dramatic changes in quasispecies diversity upon evaluating the SARS-CoV-2 populations present in the upper and lower respiratory tracts of patients with varying COVID-19 severity.

31 May 2021

Genomic study identifies marked differences between two halves of the hippocampus

A study of gene activity in the brain's hippocampus, led by UT Southwestern researchers, has identified marked differences between the region's anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.

29 May 2021

New SARS-CoV-2 lineages continue to threaten pandemic control in England, suggests genomic study

A new study shows the pattern of the rise of various strains in the UK, as shown by the data collected by the COVID-19 Genomics UK Consortium. This allows the rise and fall of 62 different viral lineages to be traced through over 300 local authorities from September 2020 to April 2021.

28 May 2021

Scientists identify many new gene variants that increase risk for depression

In the largest genetic analysis of depression to date, Veterans Affairs researchers identified many new gene variants that increase the risk for depression. The groundbreaking study helps researchers better understand the biological basis of depression and could lead to better drug treatments.

28 May 2021

Researchers use genomic sequencing technique to detect presence of various microbes

About 12,000 bacteria and viruses collected in a sampling from public transit systems and hospitals around the world from 2015 to 2017 had never before been identified, according to a study by the International MetaSUB Consortium, a global effort at tracking microbes that is led by Weill Cornell Medicine investigators.

27 May 2021

Genomic News and Research

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Nanopore sequencing contradicts human genome integration of SARS-CoV-2

Could certain genes be associated with a loss of smell in some COVID-19 patients?

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

SWOG researchers to present practice-changing research at virtual ASCO 2021

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

Researchers develop new method for sequencing single cells in an efficient manner

Ethnic diversity in genetic study identifies more genomic regions linked to type 2 diabetes-related traits

New method helps identify rare genetic disease that affects brain development

Ethnic diversity in genetic study of glycemic traits yields better results

Expanding genomic research into different ancestries yields more and better results

Could a mathematical application of information theory identify and predict SARS-CoV-2 mutations?

SARS-CoV-2 NSP14 induces potent inflammation via NF-κB pathways, finds study

SARS-CoV-2 genome mutations display convergent evolution indicating strong adaptive advantages

Intra-host SARS-CoV-2 composition varies over time, hinting at viral evolution during infection

Genomic study identifies marked differences between two halves of the hippocampus

New SARS-CoV-2 lineages continue to threaten pandemic control in England, suggests genomic study

Scientists identify many new gene variants that increase risk for depression

Researchers use genomic sequencing technique to detect presence of various microbes

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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