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SARS-CoV-2 B.1.617 variant shows modest resistance to vaccine-induced antibodies

The World Health Organization (WHO) has labeled the double mutant B.1.617 variant — first discovered in India —a variant of concern for its high transmission rate and ability to evade immune responses. New research posted to the preprint server bioRxiv finds B.1.617 can modestly reduce neutralizing antibody responses generated from the Pfizer-BioNTech vaccine.

16 May 2021

A magnetofluidic platform for SARS-CoV-2 variant and respiratory pathogen detection

Recent research published on the medRxiv* server has developed a portable, magnetofluidic cartridge platform, for automated PCR testing in <30 min, for rapid multiplexed screening of pathogens. A multidisciplinary team of researchers at Johns Hopkins University and the Johns Hopkins University School of Medicine developed these cartridges for multiplexed detection of SARS-CoV-2 with distinctive variant mutations or with Influenza A and B.

13 May 2021

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

Millions of people suffer from psoriasis, a chronic, autoimmune disorder that causes scaly patches on the skin and often precedes psoriatic arthritis. While no cure exists, treatments range from topical creams to injected medications that block inflammation.

13 May 2021

Scientists find dramatic differences between ancient gut microbiomes and modern microbes

Scientists are rapidly gathering evidence that variants of gut microbiomes, the collections of bacteria and other microbes in our digestive systems, may play harmful roles in diabetes and other diseases.

12 May 2021

Study examines a pathway responsible for the formation of tau tangles in the brain

Since the discovery of Alzheimer's disease over a century ago, two hallmarks of the devastating illness have taken center stage.

12 May 2021

CNIO researchers unravel why motor neurons die in ALS patients

In Amyotrophic Lateral Sclerosis (ALS), the progressive death of neurons that control body movement leads to paralysis of muscles in the limbs and gradually of the whole body, which ultimately makes it impossible to breathe. ALS is currently untreatable, and its cause is unknown.

12 May 2021

Novel chip-based antigen test can provide ultrasensitive detection of SARS-CoV-2, influenza A

Researchers at UC Santa Cruz have developed a novel chip-based antigen test that can provide ultrasensitive detection of SARS-CoV-2 and influenza A, the viruses that cause COVID-19 and flu, respectively.

12 May 2021

Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021

The emergence of this variant highlighted the uneven pace of mutation and selection of variants. New bioinformatics tools are the need of the hour to clarify this and confirm a dynamic evolution by tracking the mutation rates of the spike protein. It generally takes 1 – 6 months for current variants causing COVID-19 case peaks and deaths to survive the pressure of selection.

11 May 2021

Severe COVID-19 linked to genetic clotting predisposition

Thus, the need to stratify the risk of severe or critical disease in patients presenting with SARS-CoV-2 infection remains a crying necessity. A new preprint research paper posted to the medRxiv server discusses the relationship between severe disease and pre-existing susceptibility to clots and other diseases of the cardiovascular system.

11 May 2021

The travel-related origin and spread of SARS-CoV-2 B.1.620 strain

A new preprint research paper posted to the medRxiv* server describes a new variant B.1.620, which appeared in Lithuania, and is now prevalent in several countries in Europe, as well as in central Africa.

11 May 2021

Single-cell map offers a new immunotherapy target for lung cancer treatment

Researchers at The University of Texas MD Anderson Cancer Center have developed a first-of-its-kind spatial atlas of early-stage lung cancer and surrounding normal lung tissue at single-cell resolution, providing a valuable resource for studying tumor development and identifying new therapeutic targets.

11 May 2021

Lab reports 1st instance of SARS-CoV-2 variants affecting antigen test performance

Researchers from the US recently determined the sensitivity of the Quidel Sofia SARS Antigen FIA test (Sofia 2). They found a high viral load specimen that tested negative repeatedly while using this antigen test. The study is published on the preprint server, medRxiv.

10 May 2021

New implantable system can manipulate brain signals and suppress pathological coupling

As researchers learn more about the brain, it has become clear that responsive neurostimulation is becoming increasingly effective at probing neural circuit function and treating neuropsychiatric disorders, such as epilepsy and Parkinson's disease.

10 May 2021

Machine learning technique detects epigenetic drivers of cancers

Scientists have made major advances in understanding and developing treatments for many cancers by identifying genetic mutations that drive the disease.

10 May 2021

Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

In cancer, a lot of biology goes awry: Genes mutate, molecular processes change dramatically, and cells proliferate uncontrollably to form entirely new tissues that we call tumors.

10 May 2021

Esophageal cancers turn on ancient viral DNA hidden in our genome

Scientists have discovered that many esophageal cancers turn on ancient viral DNA that was embedded in our genome hundreds of millions of years ago.

10 May 2021

Korea's first large-scale project reaches milestone of sequencing 10,000 whole genomes

On April 26, UNIST and Ulsan City officially announced that their ambitious 10,000 Genome Project has finally reached the milestone of sequencing 10,000 whole genomes.

10 May 2021

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Researchers in the United States have shown that genes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the causative agent of coronavirus disease 2019 (COVID-19) – can be integrated into the genome of infected human cells.

10 May 2021

Study provides new insight on how HER2-low tumors may evolve in breast cancer patients

The finding that breast tumors can evolve to express low HER2 potentially widens the number of patients who can benefit from new investigational agents, typically novel antibody-drug conjugate therapies, that are currently in clinical trials for HER2-low tumors.

8 May 2021

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

The SARS-CoV-2 was first reported in a case from Wuhan, China, in December 2021, and subsequently became the cause of the COVID-19 pandemic that is ravaging the world today. A new study in the journal Molecular Biology and Evolution tracks its variants all over the world since the onset of the pandemic.

7 May 2021

Genomic News and Research

SARS-CoV-2 B.1.617 variant shows modest resistance to vaccine-induced antibodies

A magnetofluidic platform for SARS-CoV-2 variant and respiratory pathogen detection

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

Scientists find dramatic differences between ancient gut microbiomes and modern microbes

Study examines a pathway responsible for the formation of tau tangles in the brain

CNIO researchers unravel why motor neurons die in ALS patients

Novel chip-based antigen test can provide ultrasensitive detection of SARS-CoV-2, influenza A

Evolutionary-spreading model predicts another devastating COVID-19 peak around July 2021

Severe COVID-19 linked to genetic clotting predisposition

The travel-related origin and spread of SARS-CoV-2 B.1.620 strain

Single-cell map offers a new immunotherapy target for lung cancer treatment

Lab reports 1st instance of SARS-CoV-2 variants affecting antigen test performance

New implantable system can manipulate brain signals and suppress pathological coupling

Machine learning technique detects epigenetic drivers of cancers

Researchers study how cancer cells re-organize 3D structure of DNA to ramp up oncogene activity

Esophageal cancers turn on ancient viral DNA hidden in our genome

Korea's first large-scale project reaches milestone of sequencing 10,000 whole genomes

Researchers show SARS-CoV-2 genes can be integrated into the human genome

Study provides new insight on how HER2-low tumors may evolve in breast cancer patients

The ancestor of SARS-CoV-2’s Wuhan strain was circulating in late October 2019

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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