Preclinical News and Research

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Study reveals novel pathway to target colorectal cancer

While the emergence of precision medicine and immunotherapy has greatly improved outcomes for patients with colorectal cancer, new approaches are still needed for patients with late-stage disease who do not respond to these therapies.

26 Nov 2019

Researchers win grants to find innovative treatments for debilitating skin diseases

National leaders in research to cure debilitating skin diseases based at the Gates Center for Regenerative Medicine on the University of Colorado Anschutz Medical Campus have won a second NIH grant to further investigations of innovative treatments.

26 Nov 2019

Researchers find new way to protect against disease in MS model

Researchers have found a new and unexpected way of preventing disease in a preclinical model of multiple sclerosis (MS).

26 Nov 2019

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Novoheart, a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.

26 Nov 2019

PREDiCT: Tumor Models San Francisco Summit 2020

The community of preclinical immuno-oncology scientific Pharma and Biotechs meet again to advance their preclinical insights through robust models utilization to accelerate IO development & clinical confidence.

25 Nov 2019

FDA approves Ohio State-developed drug to treat patients with CLL and SCL

On Nov. 21, 2019, the U.S. Food and Drug Administration approved the use of the drug acalabrutinib for first-line therapy in chronic lymphocytic leukemia and small cell lymphoma.

22 Nov 2019

Wound healing events in mucous tissues could guard against AIDS

Wound healing events in mucous tissues during early infection by Simian Immunodeficiency Virus, or SIV, guard some primate species against developing AIDS, a recent study has learned.

21 Nov 2019

Frailty: An important predictor of worse outcome after traumatic spinal cord injury

A new study has shown that frailty is an important predictor of worse outcome after traumatic spinal cord injury in patients less than 75 years of age. In patients younger than 75 years, frailty was a predictor of adverse events, acute length of stay, and in-hospital mortality, as reported in an article published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

21 Nov 2019

Researchers identify a promising drug pair to attack deadly childhood brain cancers

Researchers have devised a new plan of attack against a group of deadly childhood brain cancers collectively called diffuse midline gliomas, including diffuse intrinsic pontine glioma, thalamic glioma and spinal cord glioma.

20 Nov 2019

New brain research by UTHealth student was showcased at Neuroscience 2019

Brain research by a student in a laboratory at McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth) was singled out for special attention at the Society for Neuroscience (SfN) annual meeting in Chicago Oct. 19-23.

20 Nov 2019

Certain traditional soup broths possess antimalarial properties

Researchers have found that some soups have antimalarial properties and can interrupt the life cycle of a malarial parasite.

19 Nov 2019

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

TARA Biosystems, Inc. today reported in vivo and in vitro functional data from a study of investigational candidate, MYK-491, showing that TARA's human iPSC-derived organ-on-a-chip technology can directly measure in vivo cardiac performance.

18 Nov 2019

Dementia risk perception vis-a-vis actual action among Americans

A study has shown that one in two Americans between age 50 and 64 years is aware of the risk of development of dementia with age but only 5 percent are actually visiting their healthcare providers to seek preventive and therapeutic attention.

17 Nov 2019

CSU awarded $1.2 million subcontract to accelerate tuberculosis vaccine development

A team of researchers in the Department of Microbiology, Immunology and Pathology at Colorado State University aim to advance what is known about the complex immune response necessary to prevent tuberculosis disease.

15 Nov 2019

Surgeon general’s marijuana warning omits crucial context

Speaking about a recent federal advisory on marijuana, Dr. Jerome Adams, the surgeon general, put a new spin on long-standing admonitions about the drug.

15 Nov 2019

PhoreMost and Sentinel Oncology expand partnership to advance novel allosteric PLK1 inhibitor

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and Sentinel Oncology, today announce an expansion of their collaboration to accelerate the progression of SOL686, a novel allosteric Polo-like kinase 1 (PLK1) inhibitor through preclinical development and IND enabling studies for the treatment of Glioma.

From PhoreMost 15 Nov 2019

New wearable, implantable devices may revolutionize treatment for kidney failure patients

A feature article appearing in an upcoming issue of CJASN highlights the potential of wearable and implantable devices for treating kidney failure.

14 Nov 2019

Earliest stage of hearing loss is linked to cognitive decline

Research has shown that adults with age-related hearing loss have higher rates of cognitive decline. Now, a study from researchers at Columbia University Vagelos College of Physicians and Surgeons has found that even the earliest stage of hearing loss-when hearing is still considered normal - is linked to cognitive decline.

14 Nov 2019

Study offers significant contribution for recovery of motor functions

Delivering a diversified electric message to the different fibres of the injured spinal cord through a new technology able to deliver it in a targeted and independent manner. What is the result? Greater efficiency in recovering the control of voluntary limb movements in the event of serious damage to the spinal cord.

13 Nov 2019

Russian scientists explain how an additional component can triple vaccine efficiency

A team of Russian scientists carried out a study on the cell immunity level and found out how an adjuvant called azoximer bromide increases the immunogenicity of the anti-flu vaccine.

12 Nov 2019

Preclinical News and Research

Study reveals novel pathway to target colorectal cancer

Researchers win grants to find innovative treatments for debilitating skin diseases

Researchers find new way to protect against disease in MS model

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

PREDiCT: Tumor Models San Francisco Summit 2020

FDA approves Ohio State-developed drug to treat patients with CLL and SCL

Wound healing events in mucous tissues could guard against AIDS

Frailty: An important predictor of worse outcome after traumatic spinal cord injury

Researchers identify a promising drug pair to attack deadly childhood brain cancers

New brain research by UTHealth student was showcased at Neuroscience 2019

Certain traditional soup broths possess antimalarial properties

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

Dementia risk perception vis-a-vis actual action among Americans

CSU awarded $1.2 million subcontract to accelerate tuberculosis vaccine development

Surgeon general’s marijuana warning omits crucial context

PhoreMost and Sentinel Oncology expand partnership to advance novel allosteric PLK1 inhibitor

New wearable, implantable devices may revolutionize treatment for kidney failure patients

Earliest stage of hearing loss is linked to cognitive decline

Study offers significant contribution for recovery of motor functions

Russian scientists explain how an additional component can triple vaccine efficiency

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