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Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

Researchers assessed the binding pocket of linoleic acid, an essential free-fatty acid in the receptor-binding domains of the spike protein of beta-coronaviruses.

26 Apr 2022

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

First product within new ‘in-a-box’ range, which harnesses next-generation, human-relevant Liver-on-a-Chip technology to improve the accuracy and efficiency of NASH drug discovery.

From CN Bio 26 Apr 2022

The potency of halicin against the main protease of SARS-CoV-2

A new paper published in Current Research in Chemical Biology discusses the potential of a molecule called halicin against SARS-CoV-2.

26 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

As part of World Malaria Day 2022, we interview Karine Le Roch PH.D., about her latest research into how novel antimalarial therapeutic strategies could be on the horizon, after identifying two proteins that are critical to the survival of the malaria parasite, Plasmodium falciparum.

25 Apr 2022

Prior COVID-19 protects against subsequent infections

In a recent study published in the Journal of American Medical Association (JAMA), researchers evaluated the duration and level of protection conferred by a coronavirus disease 2019 (COVID-19) infection among non-vaccinated subjects.

25 Apr 2022

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

A recent review paper, published in the MDPI’s specialized journal COVID, highlights key features of the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – and examines the potential and roadblocks in using renewable marine resources in the fight against the coronavirus disease 2019 (COVID-19).

24 Apr 2022

Study highlights a rapidly increasing patient population with long COVID and lack of treatments

A new UK study of more than 2,000 patients after hospitalization with COVID-19 presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2022, Lisbon 23-26), and published in The Lancet Respiratory Medicine shows that, one year after having COVID-19, only around one in four patients feel fully well again.

24 Apr 2022

Miniature replica of the heart could give a more accurate view of how the organ works

There's no safe way to get a close-up view of the human heart as it goes about its work: you can't just pop it out, take a look, then slot it back in.

22 Apr 2022

Metabolomics and multi-omics perspective of cancer show promise for finding new treatments

While cancer is a genetic disease, the genetic component is just one piece of the puzzle - and researchers need to consider environmental and metabolic factors as well, according to a research review by a leading expert at the University of Alberta.

22 Apr 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

Antibodies that neutralize most sarbecoviruses, including SARS-CoV-2 variants

Researchers isolate three mAbs that broadly neutralized sarbecoviruses and carried out virological and structural studies of these mAbs.

21 Apr 2022

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Three experimental blood tests used to identify people in early stages of Alzheimer's disease perform differently in Black individuals compared to white individuals, according to a new study from Washington University School of Medicine in St. Louis.

21 Apr 2022

Antibody-based treatment, endogenous immune responses, and within-host SARS-CoV-2 evolution in immunocompromised patients

Researchers investigated the interplay of all the factors responsible for within-host evolution of SARS-CoV-2 variants in immunocompromised patients.

21 Apr 2022

Study evaluates the use of a diagnostic code for Long COVID

Researchers evaluated the use of U09.9, a CD-10-CM code described as 'Post coronavirus disease 2019 (COVID-19) condition, unspecified' for post-acute COVID-19 sequelae (long COVID).

21 Apr 2022

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Researchers surveyed over 360 COVID-19 patients to characterize the SARS-CoV-2 genomic sequence diversity of individual infections.

21 Apr 2022

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Researchers developed an immunoantiviral, NanoSTING, and demonstrated its broad-spectrum antiviral properties in hamsters and mice.

21 Apr 2022

Study examines vitamin D and COVID-19 media coverage in the U.K.

A new study investigates the relationship between COVID-19 and vitamin D that has been presented in traditional media sources like U.K. newspapers.

20 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons - more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Lab grown, self-renewing muscle stem cells can repair muscle tissue damage in mice

In proof-of-concept experiments, Johns Hopkins Medicine scientists say they have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice, potentially advancing efforts to treat muscle injuries and muscle-wasting disorders in people.

20 Apr 2022

Therapeutics News and Research

Free fatty acid-binding pocket found to be preserved across spike proteins of beta coronaviruses

CN Bio introduces PhysioMimix NASH ‘in-a-box’ reagent kit

The potency of halicin against the main protease of SARS-CoV-2

Researchers develop new platform capable of mitochondrial DNA editing

World Malaria Day 2022: How the knockdown of P. falciparum RAP01 and RAP21 proteins could lead to novel antimalarial therapeutics

Prior COVID-19 protects against subsequent infections

Marine resources could be promising drug candidates against SARS-CoV-2 Omicron

Study highlights a rapidly increasing patient population with long COVID and lack of treatments

Miniature replica of the heart could give a more accurate view of how the organ works

Metabolomics and multi-omics perspective of cancer show promise for finding new treatments

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

Antibodies that neutralize most sarbecoviruses, including SARS-CoV-2 variants

Most blood tests to detect Alzheimer’s disease perform inconsistently across racial groups

Antibody-based treatment, endogenous immune responses, and within-host SARS-CoV-2 evolution in immunocompromised patients

Study evaluates the use of a diagnostic code for Long COVID

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Intranasal nanoparticle STING agonist with immunoantiviral activity against SARS-CoV-2 variants

Study examines vitamin D and COVID-19 media coverage in the U.K.

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Lab grown, self-renewing muscle stem cells can repair muscle tissue damage in mice

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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