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Lethal DNA re-replication may be used to attack cancer cells

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise to aberrant cells as those detected in many carcinomas.

4 May 2017

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

10x Genomics, a company focused on enabling the mastery of biology by accelerating genomic discovery, today announced publication of an article in the journal Nature of a collaborative research study with researchers at the Stanford University School of Medicine.

From 10x Genomics, Inc. 4 May 2017

New research on nanodiamond-enhanced MRI

Research by a collaboration of scientists in Australia and the United States demonstrates that using nanodiamonds somewhat like ‘tiny machines’ inside living patients has taken a quantum leap closer to reality.

3 May 2017

Molecular drug imaging likely to benefit children with brain tumors

Brain cancers are difficult to treat, and it can be hard to predict whether a therapy will be effective. When the patient is a child, it's even more important to predict the potential effectiveness of a drug before beginning treatment.

3 May 2017

SyMRI approach provides myelin maps in scan times of only 5 minutes

It has been a long-standing dream in MRI to move from visualizing tissue contrast differences to directly imaging patient tissue properties. Recent developments within quantitative MRI have provided substantial steps forward in measuring the basic physical properties such as T1 and T2 relaxation times or proton density.

2 May 2017

TAU researchers develop glow stick probes to detect cancerous cells

Chemiluminescence, or chemical light, is the principle behind the glow sticks (also known as light sticks) used at rock concerts and as quick tools to grab when the electricity goes out. But they can also be used to diagnose diseases by identifying concentrations of biological samples.

2 May 2017

Hair-derived keratin biomaterials show promise to regenerate skeletal muscle tissue and function

The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models of volumetric muscle loss.

27 Apr 2017

Improvements to animal testing protocols could yield more useful clinical results

The use of animals in biomedical research has long been the focus of campaigns by animal rights activists. Two leading scientists writing in the European Journal of Internal Medicine give their expert view of the importance of animal testing to medical progress and present ways it could be further improved to yield more useful clinical results.

27 Apr 2017

New model for toxicity risk assessment could reduce reliance on animal testing

Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.

24 Apr 2017

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

An off-the-shelf dietary supplement available for pennies per dose demonstrated the ability to reverse cellular damage linked to specific genetic mutations in transgenic fruit flies, an experimental model of genetic mutation-induced renal cell injury that features striking similarities to humans, a Children's National Health System research team reports April 20 in Journal of the American Society of Nephrology.

21 Apr 2017

Latest advances in antibody delivery mediated by rAAV for treatment of chronic and infectious diseases

Monoclonal antibody-based therapies have revolutionized treatments of cancer and autoimmune diseases because of their specificity and limited toxicity.

21 Apr 2017

Strawberry extract can inhibit spread of breast cancer cells, mice study shows

A study by European and Latin American researchers has shown that strawberry extract can inhibit the spread of laboratory-grown breast cancer cells, even when they are inoculated in female mice to induce tumours.

19 Apr 2017

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

18 Apr 2017

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Through experimental work, an international team of researchers led by City of Hope's Defu Zeng, professor of diabetes immunology and hematopoietic cell transplantation, believe they may have found a way to prevent graft-versus-host disease after stem cell transplants while retaining the transplants' positive effects on fighting leukemia and lymphoma.

18 Apr 2017

Discovery of additional viral reservoir reveals new target for HIV cure research

HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system.

17 Apr 2017

Study shows um-PEA as safe and efficacious adjuvant treatment for advanced PD patients

Parkinson disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

12 Apr 2017

New nanowire technology may serve as platform to screen drugs for neurological diseases

A team led by engineers at the University of California San Diego has developed nanowires that can record the electrical activity of neurons in fine detail.

11 Apr 2017

Feinstein Institute research may lead to new treatment option for low-grade gliomas

Marc Symons, PhD, professor in The Feinstein Institute for Medical Research's Karches Center for Oncology Research, is examining if a common medication administered to treat pinworms, could replace the current treatment used for certain brain cancers.

11 Apr 2017

Researchers design first light-activated drug for treatment of pain

A team of the Institute of Neurosciences of the University of Barcelona has participated in the design of the first light-activated drug -the JF-NP-26, for the treatment of pain, according to a research with animal models published in the journal eLife.

11 Apr 2017

New transgenic mouse could help monitor potential dangers of emerging influenza viruses

Researchers in Germany have developed a transgenic mouse that could help scientists identify new influenza virus strains with the potential to cause a global pandemic.

10 Apr 2017

in vivo News and Research

Lethal DNA re-replication may be used to attack cancer cells

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

New research on nanodiamond-enhanced MRI

Molecular drug imaging likely to benefit children with brain tumors

SyMRI approach provides myelin maps in scan times of only 5 minutes

TAU researchers develop glow stick probes to detect cancerous cells

Hair-derived keratin biomaterials show promise to regenerate skeletal muscle tissue and function

Improvements to animal testing protocols could yield more useful clinical results

New model for toxicity risk assessment could reduce reliance on animal testing

Transgenic fruit flies can shed light on genetic mutations that underlie kidney disease in humans

Latest advances in antibody delivery mediated by rAAV for treatment of chronic and infectious diseases

Strawberry extract can inhibit spread of breast cancer cells, mice study shows

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

Researchers find new way to prevent graft-versus-host disease after stem cell transplants

Discovery of additional viral reservoir reveals new target for HIV cure research

Study shows um-PEA as safe and efficacious adjuvant treatment for advanced PD patients

New nanowire technology may serve as platform to screen drugs for neurological diseases

Feinstein Institute research may lead to new treatment option for low-grade gliomas

Researchers design first light-activated drug for treatment of pain

New transgenic mouse could help monitor potential dangers of emerging influenza viruses

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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