Clinical Trial News and Research

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Paxlovid can prevent hospitalization and death for patients infected with Omicron variants, study shows

Though many Coloradans are proceeding as though the COVID-19 pandemic is over, the virus continues to circulate, evolve and have an impact - especially for older adults and those with underlying medical conditions.

13 Feb 2023

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Researchers assessed the impact of caloric restriction on biological aging among the comprehensive assessment of the long-term effects of reducing the intake of energy (CALERIE) randomized controlled trial participants.

13 Feb 2023

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Declines in prostate-specific antigen (PSA) level after treatment with the next-generation androgen receptor inhibitor drug enzalutamide predict improved survival rates in men with non-metastatic castration-resistant prostate cancer (nmCRPC), reports The Journal of Urology, an Official Journal of the American Urological Association.

10 Feb 2023

Morristown Medical Center reaches significant milestone of performing over 4,000 TAVR

Morristown Medical Center's Gagnon Cardiovascular Institute's structural heart program reached a significant milestone of performing over 4,000 transcatheter aortic valve replacement (TAVR) procedures with well over 650 in 2022 alone.

10 Feb 2023

Can carbohydrate be reduced too low for weight loss, and glycemic control?

A new review in the Journal of Clinical Lipidology aimed to describe the definitions of carbohydrate-restricted dietary patterns, the potential benefits related to cardiometabolic risk factors, and whether healthcare professionals should consider it for glycemic management and weight loss.

9 Feb 2023

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Stand Up To Cancer today announced four teams focused on increasing diversity in early phase cancer clinical trials.

8 Feb 2023

Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

8 Feb 2023

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

As the Alzheimer's disease scientific community, patients, and families seek to understand the results of clinical trials of new Alzheimer's treatments, the Alzheimer's Association convened an expert work group to discuss an important and timely issue: the "clinical meaningfulness" of results from these studies.

7 Feb 2023

Study finds distinct differences in how the brain releases dopamine in patients with alcohol use disorder

Dopamine is a neurotransmitter that's made in the brain and acts as a chemical messenger, communicating between nerve cells in the brain and the rest of the body.

7 Feb 2023

AI can be a powerful tool to help identify lung nodules on chest X-rays

In a pioneering, randomized controlled study evaluating the effect of artificial intelligence (AI)-based software in real clinical practice, researchers found that AI significantly improved the detection of lung nodules on chest X-rays.

7 Feb 2023

Early treatment of diabetes-related eye disease does not improve visual acuity

While early treatment of diabetes-related eye disease slowed progression to severe disease, it did not improve visual acuity compared with treating more severe disease once it developed, according to a clinical study from the DRCR Retina Network.

7 Feb 2023

Diet, microbial metabolites, and cytokine levels correlate with depression and anxiety symptoms in obese individuals

Researchers determine the association between diet, microbe-derived metabolites, and cytokine levels with anxiety and depression among obese adults.

6 Feb 2023

New type of immunotherapy effective in mice with ovarian cancer

CAR T-cell therapy, a certain kind of cancer treatment in which the immune system's T cells are programmed to attack tumor cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer.

6 Feb 2023

The effectiveness of intranasal COVID-19 vaccination in healthy adults

A recent study discusses the safety profiles and immunogenicity of the nasal BBV154 COVID-19 vaccine in healthy adults.

3 Feb 2023

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

NRG Oncology Phase III clinical trial, NRG-GY018, evaluating pembrolizumab in combination with standard of care chemotherapy (carboplatin and paclitaxel) met its primary endpoint of progression free survival (PFS) for the treatment of patients with stage III-IV or recurrent endometrial carcinoma, regardless of mismatch repair status.

3 Feb 2023

Cerba Research and Teddy Lab sign Memorandum of Understanding on entering into a discussion for Joint Venture

Cerba Research announced today a Memorandum of Understanding with Teddy Clinical Research Laboratory (Wuxi, China), a preeminent central lab provider covering mainland China, to lay the foundation for an in-depth discussion towards the creation of a Joint Venture.

From Cerba Research 3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

FSU psychologist wins NIA grant to treat anxiety in older adults with Alzheimer's, cognitive impairment

For the more than 6 million Americans living with Alzheimer's disease, related dementias, or mild cognitive impairment, anxiety is often an accompanying challenge.

3 Feb 2023

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

An unexpected discovery made by experts at the Brain Tumor Center at Cincinnati Children's while studying a rare-but-deadly type of brain tumor may also lead to improved treatments for several other forms of cancer that share a common influencing factor called a YAP fusion protein.

2 Feb 2023

BCG vaccine does not protect elderly with co-morbidities against COVID-19

The tuberculosis vaccine (or BCG vaccine) does not protect elderly with co-morbidities against disease symptoms caused by a coronavirus infection.

2 Feb 2023

Clinical Trial News and Research

Paxlovid can prevent hospitalization and death for patients infected with Omicron variants, study shows

Long-term caloric restriction has a small effect on the DNA methylation measure of the pace of aging

Declining PSA levels predict improved survival rates in men with non-metastatic castration-resistant prostate cancer

Morristown Medical Center reaches significant milestone of performing over 4,000 TAVR

Can carbohydrate be reduced too low for weight loss, and glycemic control?

Four teams supported by SU2C focus on increasing diversity in early phase cancer clinical trials

Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Expert work group examines and redefines “clinical meaningfulness” in Alzheimer’s

Study finds distinct differences in how the brain releases dopamine in patients with alcohol use disorder

AI can be a powerful tool to help identify lung nodules on chest X-rays

Early treatment of diabetes-related eye disease does not improve visual acuity

Diet, microbial metabolites, and cytokine levels correlate with depression and anxiety symptoms in obese individuals

New type of immunotherapy effective in mice with ovarian cancer

The effectiveness of intranasal COVID-19 vaccination in healthy adults

Pembrolizumab in combination with chemotherapy improves progression free survival for women with advanced or recurrent endometrial cancer

Cerba Research and Teddy Lab sign Memorandum of Understanding on entering into a discussion for Joint Venture

Molnupiravir-related mutational signatures among COVID-19 patients

FSU psychologist wins NIA grant to treat anxiety in older adults with Alzheimer's, cognitive impairment

Unexpected discovery may lead to improved treatments for YAP fusion-driven cancers

BCG vaccine does not protect elderly with co-morbidities against COVID-19

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