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SWOG investigators report results from DART clinical trial of immunotherapy combination for rare gynecologic cancers

Results from the S1609 DART clinical trial, which tested an immunotherapy combination of ipilimumab plus nivolumab in 53 cohorts of patients with rare cancers, are being reported for five cohorts of patients who had rare gynecologic cancers.

18 Apr 2023

Green Mediterranean diet substantially regresses proximal aortic stiffness

The green Mediterranean – high polyphenols diet substantially regresses proximal aortic stiffness (PAS), a marker of vascular aging and increased cardiovascular risk.

18 Apr 2023

New software tool set to improve the management of elderly atrial fibrillation patients with comorbidities

A novel software tool set to improve the management of elderly atrial fibrillation patients with multiple conditions is being designed by the EU-funded and ESC-coordinated EHRA-PATHS consortium. The latest updates on this clinical innovation will be presented at EHRA 2023, a scientific congress of the European Society of Cardiology.

18 Apr 2023

Combination treatment could improve stem cell transplantation process for multiple myeloma patients

The standard treatment for patients with multiple myeloma often includes stem cell transplantation in which the patient's own stem cells are harvested and stored while the patient receives intensive chemotherapy to kill the cancer.

17 Apr 2023

Experimental mRNA vaccine plus an immunotherapy reduced the likelihood of melanoma recurrence

The combination of an experimental mRNA vaccine with an immunotherapy reduced the likelihood of melanoma recurring or causing death by 44% when compared to immunotherapy alone, a new clinical trial shows.

17 Apr 2023

Many melanoma patients could avoid the risk for toxicity from combination therapies, study suggests

Data from a national clinical trial shows that a striking 89% of patients with desmoplastic melanoma responded to immunotherapy (pembrolizumab) alone, suggesting that many patients could avoid the risk for toxicity from combination therapies and achieve cancer control with this approach to treatment.

17 Apr 2023

Study uncovers hallmarks to improving pancreatic cancer therapy

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

13 Apr 2023

Earlier intervention leads to better gains for autistic children

Researchers from Children's Hospital of Philadelphia (CHOP), Florida State University (FSU), and the University of California, Los Angeles (UCLA) have demonstrated that starting intervention coaching parents of autistic toddlers as early as 18 months leads to better gains in language, social communication, and daily living skills.

13 Apr 2023

UCSF surgeons perform two novel minimally invasive cardiac procedures for the first time

UC San Francisco interventional cardiologists and interventional echocardiographers recently performed two novel minimally invasive cardiac procedures for the first time in the health system.

13 Apr 2023

The drug company that prospered without creating any drugs

The new drug looked so promising — except for that one warning sign.

13 Apr 2023

Placebo in addition to methadone shown to be feasible treatment for opioid use disorder

There were more than 100,000 reported deaths from opioid overdoses in 2021, according to the Centers for Disease Control and Prevention.

12 Apr 2023

Cedars-Sinai Cancer collaborates on a streamlined clinical trial design in Pragmatica-Lung Study

Investigators from Cedars-Sinai Cancer are collaborating on a streamlined clinical trial design in a study called Pragmatica-Lung.

12 Apr 2023

AI can identify subtle language and audio changes in patients at early stages of Alzheimer's

New technologies that can capture subtle changes in a patient's voice may help physicians diagnose cognitive impairment and Alzheimer's disease before symptoms begin to show, according to a UT Southwestern Medical Center researcher who led a study published in the Alzheimer's Association publication Diagnosis, Assessment & Disease Monitoring.

12 Apr 2023

Women with multiple tumors in one breast may be able to avoid a mastectomy

Patients who have multiple tumors in one breast may be able to avoid a mastectomy if the tumors can be removed while leaving enough breast tissue, according to research led by the Alliance in Clinical Trials in Oncology and Mayo Clinic Comprehensive Cancer Center.

12 Apr 2023

Pragmatica-Lung Study aims to increase accessibility to cancer clinical trials

The National Cancer Institute, part of the National Institutes of Health (NIH), has helped launch a phase 3 randomized clinical trial (NCT05633602) of a two-drug combination to treat patients with advanced non-small cell lung cancer (NSCLC).

12 Apr 2023

University Hospital Bonn coordinates eWHORM project to combat worm infections in sub-Saharan Africa

African and European partners join forces to enable the World Health Organisation's (WHO) "Road Map for Neglected Tropical Diseases" (NTDs) and reduce the burden of disease associated with worm infections.

11 Apr 2023

Daily statin medication could improve cardiovascular outcomes in people with HIV

A National Institutes of Health clinical trial was stopped early because a daily statin medication was found to reduce the increased risk of cardiovascular disease among people living with HIV in the first large-scale clinical study to test a primary cardiovascular prevention strategy in this population.

11 Apr 2023

Personalized drug therapy for hypertension may provide maximum benefit

Patients treated with blood pressure-lowering drugs can experience much greater improvements from a change of medication than from doubling the dose of their current medication.

11 Apr 2023

A call for a universal definition of post-COVID-19 condition (PCC)

Researchers assessed the published definitions of the post-coronavirus disease 2019 condition.

10 Apr 2023

Leveraging cell self-destruction to treat glioblastoma tumors

Glioblastoma is the most common type of brain tumor in adults. The disease is 100% fatal and there are no cures, making it the most aggressive type of cancer. Such a poor prognosis has motivated researchers and neurosurgeons to understand the biology of tumors with the goal of creating better therapies.

7 Apr 2023

Clinical Trial News and Research

SWOG investigators report results from DART clinical trial of immunotherapy combination for rare gynecologic cancers

Green Mediterranean diet substantially regresses proximal aortic stiffness

New software tool set to improve the management of elderly atrial fibrillation patients with comorbidities

Combination treatment could improve stem cell transplantation process for multiple myeloma patients

Experimental mRNA vaccine plus an immunotherapy reduced the likelihood of melanoma recurrence

Many melanoma patients could avoid the risk for toxicity from combination therapies, study suggests

Study uncovers hallmarks to improving pancreatic cancer therapy

Earlier intervention leads to better gains for autistic children

UCSF surgeons perform two novel minimally invasive cardiac procedures for the first time

The drug company that prospered without creating any drugs

Placebo in addition to methadone shown to be feasible treatment for opioid use disorder

Cedars-Sinai Cancer collaborates on a streamlined clinical trial design in Pragmatica-Lung Study

AI can identify subtle language and audio changes in patients at early stages of Alzheimer's

Women with multiple tumors in one breast may be able to avoid a mastectomy

Pragmatica-Lung Study aims to increase accessibility to cancer clinical trials

University Hospital Bonn coordinates eWHORM project to combat worm infections in sub-Saharan Africa

Daily statin medication could improve cardiovascular outcomes in people with HIV

Personalized drug therapy for hypertension may provide maximum benefit

A call for a universal definition of post-COVID-19 condition (PCC)

Leveraging cell self-destruction to treat glioblastoma tumors

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