Preclinical News and Research

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Vaccine for Lassa fever set to enter clinical testing in humans

There is currently no vaccine for the Lassa arenavirus, which causes Lassa fever. This hemorrhagic fever, endemic in West Africa, infects up to 300,000 people each year.

24 Oct 2019

MR Solutions launches advanced PET/CT preclinical imaging range at EANM ‘19

MR Solutions has launched a complete range of advanced PET/CT preclinical imaging systems at EANM ‘19, (European Association of Nuclear Medicine) last week in Barcelona. The range comprising four models, including a small benchtop PET/CT, can accommodate small animals up to 12 kg.

24 Oct 2019

PREDiCT: 4th Annual 3D Tissue Models discovery & development

During the 2019 edition of the PREDiCT: 3D Tissue Models Summit, we caught up with StemoniX ahead of their presentation to gain insight on their current work and future projects!

From PREDiCT 24 Oct 2019

Discovery reveals why newer PD-1 targeted therapies sometimes fail

Researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies.

23 Oct 2019

Novel noninvasive imaging technique can provide information about thyroid disorders

A combination of multispectral optoacoustic tomography (MSOT) and ultrasound has been used to noninvasively characterize a range of thyroid disorders, according to new research published in the October issue of The Journal of Nuclear Medicine.

23 Oct 2019

Sanford Burnham Prebys scientist receives $3.58 million to advance treatment for opioid-use disorders

The National Institute on Drug Abuse, part of the National Institutes of Health, awarded a $3.58 million grant to Sanford Burnham Prebys scientist Anthony Pinkerton, Ph.D., to advance a potential treatment for opioid-use disorders, called SBI-553.

23 Oct 2019

Polymerized estrogen can protect nervous system cells and promote regeneration

Spinal cord damage that causes paralysis and reduced mobility doesn't always stop with the initial trauma, but there are few treatment options to halt increased deterioration -- and there is no cure.

23 Oct 2019

LSU Health New Orleans awarded $1.74 million to advance research on Usher syndrome

Jennifer J. Lentz, PhD, Associate Professor at LSU Health New Orleans Neuroscience Center of Excellence and Departments of Otorhinolaryngology, Genetics and Ophthalmology, in collaboration with Robert K. Koenekoop MD, PhD and Professor of Pediatric Surgery, Human Genetics and Ophthalmology at McGill University in Montreal, Quebec, Canada, has been awarded a $1.74 million USD grant to advance research on Usher syndrome.

22 Oct 2019

Autism spectrum disorder could be triggered by low placental steroid levels

A recent experimental study has shown that one reason for the occurrence of autism spectrum disorder (ASD) could be the deficit of a placental steroid hormone called allopregnanolone. The reason is that this hormone plays a critical role in the normal development of the brain in fetal life.

21 Oct 2019

Cantabio, LIH jointly investigate DJ-1 targeting compounds in immune associated diseases

DJ-1 is well known as an important target for the treatment of a number of diseases such as Parkinson's disease. Cantabio has been developing novel small molecule therapeutic program targeting the DJ-1 protein with a focus on Parkinson's and also exploring a number of other disease areas.

21 Oct 2019

Columbia researchers capture new detailed images of a temperature-sensing molecule

Columbia University researchers have captured new detailed images of a temperature-sensing molecule in its open, intermediate, and closed states.

21 Oct 2019

Peptide-based nanoparticles can suppress pancreatic cancer growth without adverse effects

Despite advances in cancer survival, more than 90 percent of people with pancreatic cancer die within five years. Most patients with pancreatic tumors (and half of those with colorectal cancers) carry a mutation in the KRAS gene, which normally controls cell growth and death.

21 Oct 2019

Insufficient placental steroid may increase autism spectrum disorder risk

A study in experimental models suggests that allopregnanolone, one of many hormones produced by the placenta during pregnancy, is so essential to normal fetal brain development that when provision of that hormone decreases or stops abruptly - as occurs with premature birth - offspring are more likely to develop autism-like behaviors.

20 Oct 2019

Creatine serves as a molecular battery to power killer T cells' fight against cancer

Creatine, the organic acid that is popularly taken as a supplement by athletes and bodybuilders, serves as a molecular battery for immune cells by storing and distributing energy to power their fight against cancer, according to new UCLA research.

18 Oct 2019

Highly diluted candidate Ebola vaccine remains fully protective against disease in macaques

A single dose of a highly diluted VSV-Ebola virus vaccine--approximately one-millionth of what is in the vaccine being used to help control the ongoing Ebola outbreak in the Democratic Republic of the Congo (DRC)--remains fully protective against disease in experimentally infected monkeys, according to National Institutes of Health scientists.

18 Oct 2019

Yale scientists build powerful genomic research platform to study cervical cancer

Yale Cancer Center scientists have built a powerful genomic research platform to study cervical cancer, a disease that often is untreatable if it progresses after surgery or primary chemo-radiation treatment.

17 Oct 2019

Signaling defects could cause congenital heart condition

A congenital heart condition known as left ventricular non-compaction (LVNC) - which occurs when muscly projections in the embryonic heart fail to transform into compact heart muscle - could be caused by signaling defects, according to new preclinical research led by Duke-NUS Medical School in Singapore.

17 Oct 2019

Scientists harness the power of immune system to test novel cancer treatment

The field of immunotherapy has revolutionized the way people with incurable cancers are treated, saving the lives of many people whose disease would have otherwise been seen as a death sentence. Despite its success in treating people with deadly forms of leukemia and lymphoma, there are still many people who do not benefit from the treatment or eventually experience a relapse of their cancer.

16 Oct 2019

Drug may improve the safety of cannabis use in early pregnancy

Cannabis use during pregnancy may increase the risk of psychosis in children. Scientists have now found a drug that can reduce the effects of THC on the fetus.

16 Oct 2019

BioStreamline: Streamlining the development of next generation biotherapeutics

A collaboration to streamline the development of cost-effective next generation biotherapeutics will host a dissemination event at CPI.

From Fluidic Sciences and Sphere Bio 16 Oct 2019

Preclinical News and Research

Vaccine for Lassa fever set to enter clinical testing in humans

MR Solutions launches advanced PET/CT preclinical imaging range at EANM ‘19

PREDiCT: 4th Annual 3D Tissue Models discovery & development

Discovery reveals why newer PD-1 targeted therapies sometimes fail

Novel noninvasive imaging technique can provide information about thyroid disorders

Sanford Burnham Prebys scientist receives $3.58 million to advance treatment for opioid-use disorders

Polymerized estrogen can protect nervous system cells and promote regeneration

LSU Health New Orleans awarded $1.74 million to advance research on Usher syndrome

Autism spectrum disorder could be triggered by low placental steroid levels

Cantabio, LIH jointly investigate DJ-1 targeting compounds in immune associated diseases

Columbia researchers capture new detailed images of a temperature-sensing molecule

Peptide-based nanoparticles can suppress pancreatic cancer growth without adverse effects

Insufficient placental steroid may increase autism spectrum disorder risk

Creatine serves as a molecular battery to power killer T cells' fight against cancer

Highly diluted candidate Ebola vaccine remains fully protective against disease in macaques

Yale scientists build powerful genomic research platform to study cervical cancer

Signaling defects could cause congenital heart condition

Scientists harness the power of immune system to test novel cancer treatment

Drug may improve the safety of cannabis use in early pregnancy

BioStreamline: Streamlining the development of next generation biotherapeutics

Event guide: 4th LNP Formulation & Process Development Summit eBook

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