Antipsychotic News and Research

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Antipsychotics are medicines used to treat the symptoms of mental disorders such as schizophrenia, depression, bipolar disorder (sometimes called manic-depressive illness), anxiety disorders, and attention deficit-hyperactivity disorder (ADHD). Sometimes medications are used with other treatments such as psychotherapy.

Adjunctive brexpiprazole boosts schizophrenia patients' information processing speed

Cognitive impairment, including decreased attention and memory, remains one of the most disabling aspects of schizophrenia, affecting social life of patients.

12 Feb 2026

Promising new speech biomarker could enrich antipsychotic clinical trials

Researchers have identified a promising new speech biomarker that could significantly enrich clinical trials by reducing sample size requirements and enhancing statistical outcomes.

11 Feb 2026

Trazodone linked to safer delirium outcomes in older adults

A large U.S. study suggests that older adults hospitalized with delirium may experience better outcomes when treated with trazodone, commonly used to treat depression and sleep problems, rather than commonly used antipsychotic medications.

3 Feb 2026

Study finds growing long-term antipsychotic prescribing in elderly dementia patients

When agitated dementia patients wander or shout through the night, families and caregivers understandably feel the need to treat this frightening and potentially dangerous behavior. Antipsychotic medications are often resorted to with such patients, contributing to increases in antipsychotic treatment rates among older people.

16 Jan 2026

Research finds persistent prescribing of risky medications to older adults with dementia

Despite years of clinical guidelines warning against the practice, one in four Medicare beneficiaries with dementia is prescribed brain-altering medications linked to falls, confusion, and hospitalization, according to new research to be published January 12 in the peer-reviewed journal JAMA.

12 Jan 2026

Unveiling genetic links between schizophrenia and osteoporosis

A comprehensive genetic investigation led by Dr. Feng Liu at Tianjin Medical University General Hospital has uncovered striking molecular connections between schizophrenia and bone health, identifying 195 shared genetic loci that may explain why psychiatric patients face elevated fracture risks.

6 Jan 2026

Machine learning models can help diagnose ALS earlier from a blood sample

Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests.

10 Dec 2025

Novel therapy for psychosis tackles disturbing mental imagery

A pioneering therapy targeting distressing and disturbing mental images for people with psychosis could lead to a transformative intervention for a condition estimated to cost England almost £12 billion a year.

6 Nov 2025

Researchers identify patient response patterns to novel schizophrenia medication

Each year, about 100,000 Americans experience psychosis, a serious condition that disrupts thoughts and perceptions so profoundly that it can distort a person's sense of reality.

6 Nov 2025

Researchers visualize how brain network development is altered in rare childhood disorder

Researchers at the VIB-UAntwerp Center for Molecular Neurology have visualized how brain network development is altered in a model of KCNQ2-related developmental and epileptic encephalopathy, a rare childhood brain disorder.

31 Oct 2025

Study links poor sleep to adverse health outcomes in seniors

Sleep problems affect more than one in five residents in long-term care facilities, with pain, daytime napping and certain medications emerging as key contributors.

28 Oct 2025

Genetic inflammatory signature defines depression subtypes and treatment response

Researchers led by Prof. Alessandro Serretti at Kore University of Enna have identified a genetic inflammatory signature that defines specific depression subtypes and influences how patients respond to antidepressant medications, according to new peer-reviewed research published today in Genomic Psychiatry.

21 Oct 2025

Common hospice medications may carry major unintended risks for people with dementia

Hospice care aims to bring comfort, peace, and dignity to patients at the end of life. Yet for the growing number of Americans with dementia who enter hospice, their course is often long and unpredictable - making it especially important to ensure treatments align with each person's goals and stage of illness.

14 Oct 2025

Dermatological symptoms could signal higher risk in psychiatric patients

Scientists have discovered that mental health patients who have skin conditions may be more at risk of worse outcomes, including suicidality and depression.

13 Oct 2025

Study links skin conditions to worse outcomes in mental health patients

Scientists have discovered that mental health patients who have skin conditions may be more at risk of worse outcomes, including suicidality and depression.

9 Oct 2025

National Institute of Mental Health awards $3.6M grant to advance ADHD medication response research

Approximately 7 million children in the United States between the ages of three and 17 have been diagnosed with attention deficit hyperactivity disorder (ADHD), according to the Centers For Disease Control and Prevention.

19 Sep 2025

People with schizophrenia are more likely to develop COPD

People with schizophrenia are more likely to develop chronic obstructive pulmonary disease (COPD), suggesting a possible syndemic relationship between the two diseases, in addition to people not seeking appropriate medical care.

26 Aug 2025

As California’s behavioral health workforce buckles, help is years away

This spring, the Good News Rescue Mission, which runs the only emergency homeless shelter in Shasta County, received a game-changing $17.8 million state grant to build a 75-bed residential treatment facility in a region where thousands struggle with drug and alcohol addiction.

6 Aug 2025

Mapping the brain’s serotonin switch could lead to better antidepressants

In a discovery that could guide the development of next-generation antidepressants and antipsychotic medications, researchers at the Icahn School of Medicine at Mount Sinai have developed new insights into how a critical brain receptor works at the molecular level and why that matters for mental health treatments.

1 Aug 2025

Mexican neuroscientist's journey from exile to schizophrenia research breakthroughs

In a revealing Genomic Press Interview published today in Brain Medicine, Dr. Camilo de la Fuente-Sandoval shares how personal history and scientific passion converged to create groundbreaking advances in schizophrenia treatment prediction.

29 Jul 2025