Aortic Stenosis News and Research

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Single antiplatelet therapy after TAVR linked to lower mortality and bleeding

Findings from the Transfusion Requirements in Transcatheter Aortic Valve Implantation (TRITAVI) registry demonstrate that single antiplatelet therapy (SAPT) after transcatheter aortic valve replacement (TAVR) is associated with a significantly lower incidence of six-month mortality and major bleeding risk compared to dual antiplatelet therapy (DAPT).

2 May 2025

Electronic alerts could improve survival for patients with severe aortic stenosis

A new method of alerting clinical care providers holds promise for increasing treatment and improving survival for patients with severe aortic stenosis (AS), a valvular heart condition that can be deadly when left untreated.

23 Apr 2025

Trilogy valve demonstrates safety and effectiveness in treating aortic regurgitation

Patients who underwent transcatheter aortic valve replacement (TAVR) with a valve designed to treat aortic regurgitation had an overall mortality rate of just 8.1% at one year, well below the trial's prespecified goal of 25% to show non-inferiority, according to a study presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

31 Mar 2025

Embolic protection device does not reduce stroke rate in TAVR procedure

A device designed to remove embolic material—fragments of tissue that can be released into the bloodstream during transcatheter aortic valve replacement (TAVR)—did not result in a reduction in the rate of stroke, according to a randomized trial presented at the American College of Cardiology's Annual Scientific Session.

31 Mar 2025

Heart failure patients benefit from dapagliflozin after TAVR procedure

Patients with heart failure who took dapagliflozin, a sodium-glucose co-transporter-2 (SGLT-2) inhibitor, after undergoing transcatheter aortic valve replacement (TAVR) were significantly less likely to die or experience worsening heart failure at one year compared with patients who did not take the drug, according to a study presented at the American College of Cardiology's Annual Scientific Session.

31 Mar 2025

ICHOM develops standard dataset that defines heart valve disease outcomes

The International Consortium for Health Outcomes Measurement (ICHOM) has developed a globally inclusive standard dataset of 16 patient-centered outcome measures for people with heart valve disease, regardless of treatment (surgical or transcatheter procedure), according to a new report published today in the American Heart Association's journal Circulation: Cardiovascular Quality & Outcomes.

17 Feb 2025

Olpasiran significantly lowers "bad cholesterol" linked to cardiovascular risk

The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai researcher of a phase 2 trial.

13 Feb 2025

Unveiling the genetic roots of bicuspid aortic valve

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease, according to a new study led by UTHealth Houston researchers.

16 Jan 2025

How added sugars and sweetened foods impact the risk of 7 cardiovascular diseases

Researchers examine the risk of seven different types of cardiovascular diseases associated with added and free sugar in foods and beverages.

12 Dec 2024

Study finds divergent relationship between different sugar sources and cardiovascular disease risk

A little of what you fancy does you good… unless it's a fizzy drink. Scientists studying the impact of sugar on the risk of cardiovascular disease have found that eating too much added sugar increases your risk of stroke or aneurysm, but eating a few treats is associated with a lower risk of cardiovascular diseases.

9 Dec 2024

Insulin resistance linked to increased risk of aortic stenosis

A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease – aortic stenosis (AS).

27 Nov 2024

Muvalaplin shows promise in lowering Lp(a) levels in clinical trial

A clinical trial testing muvalaplin, a novel oral medication, was able to safely and effectively lower high levels of lipoprotein (a), according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

19 Nov 2024

AI program enhances echocardiogram interpretation and reduces wait times

Using an artificial intelligence program to read echocardiograms may reduce the wait time for results and help lead to more timely medical care, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

18 Nov 2024

Study challenges early intervention for asymptomatic aortic stenosis

The EVOLVED trial found that early aortic valve intervention in patients with asymptomatic severe aortic stenosis (AS) and mid-wall myocardial fibrosis on magnetic resonance imaging did not reduce the incidence of the composite primary endpoint of all-cause death or unplanned aortic stenosis hospitalization compared with guideline-directed conservative management.

30 Oct 2024

Cardiac damage framework may identify patients who could benefit from earlier TAVR

Findings from the TAVR UNLOAD study found limited benefits of transcatheter aortic valve replacement (TAVR) in the treatment of heart failure (HF) with reduced ejection fraction (HFrEF) and moderate aortic stenosis (AS).

29 Oct 2024

Early intervention with TAVR proves safe and effective for asymptomatic aortic stenosis

The first powered randomized trial examining early intervention with transcatheter aortic valve replacement (TAVR) in patients with asymptomatic, severe aortic stenosis (AS) found this strategy to be both a safe and effective alternative to clinical surveillance (CS).

29 Oct 2024

European Society of Cardiology highlights underrecognized link between obesity and heart disease

Obesity is a key factor in cardiovascular disease, prompting the ESC to recommend comprehensive strategies for prevention and management to reduce health risks.

3 Sep 2024

Study reveals key genetic markers for early onset bicuspid aortic valve complications

Genetic variants linked to a rare form of bicuspid aortic valve disease that affects young adults and can lead to dangerous and potentially life-threatening aortic complications have been identified by researchers at UTHealth Houston.

2 Sep 2024

TAVI outperforms surgery in reducing complications for women with severe aortic stenosis

Transcatheter aortic valve implantation (TAVI) was superior to surgical aortic valve replacement for reducing death, stroke or rehospitalization in women with severe aortic stenosis, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

TAVI patients with coronary artery disease can derive benefits from percutaneous coronary intervention

Performing percutaneous coronary intervention (PCI) significantly improved outcomes in patients with stable coronary artery disease (CAD) and severe aortic stenosis selected for transcatheter aortic valve implantation (TAVI), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

Aortic Stenosis News and Research

Single antiplatelet therapy after TAVR linked to lower mortality and bleeding

Electronic alerts could improve survival for patients with severe aortic stenosis

Trilogy valve demonstrates safety and effectiveness in treating aortic regurgitation

Embolic protection device does not reduce stroke rate in TAVR procedure

Heart failure patients benefit from dapagliflozin after TAVR procedure

ICHOM develops standard dataset that defines heart valve disease outcomes

Olpasiran significantly lowers "bad cholesterol" linked to cardiovascular risk

Unveiling the genetic roots of bicuspid aortic valve

How added sugars and sweetened foods impact the risk of 7 cardiovascular diseases

Study finds divergent relationship between different sugar sources and cardiovascular disease risk

Insulin resistance linked to increased risk of aortic stenosis

Muvalaplin shows promise in lowering Lp(a) levels in clinical trial

AI program enhances echocardiogram interpretation and reduces wait times

Study challenges early intervention for asymptomatic aortic stenosis

Cardiac damage framework may identify patients who could benefit from earlier TAVR

Early intervention with TAVR proves safe and effective for asymptomatic aortic stenosis

European Society of Cardiology highlights underrecognized link between obesity and heart disease

Study reveals key genetic markers for early onset bicuspid aortic valve complications

TAVI outperforms surgery in reducing complications for women with severe aortic stenosis

TAVI patients with coronary artery disease can derive benefits from percutaneous coronary intervention

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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