BCG Vaccine News and Research

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The BCG Vaccine is a vaccine containing bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, with non-specific immunoadjuvant and immunotherapeutic activities. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG vaccine likely activates a Th1 cytokine response that includes the induction of interferon. Vaccination with BCG vaccine may be immunoprotective against infection with Mycobacterium tuberculosis.

The BCG vaccine does not decrease the risk of COVID-19 in healthcare workers

Researchers evaluated whether the BCG vaccine could protect healthcare workers against coronavirus disease 2019.

28 Apr 2023

What is the effect of prior BCG vaccination on the immunogenicity and efficacy of subsequent COVID-19 vaccination?

Researchers assessed the impact of BCG vaccination on the protection provided by SARS-CoV-2 vaccination.

28 Mar 2023

BCG vaccine does not protect elderly with co-morbidities against COVID-19

The tuberculosis vaccine (or BCG vaccine) does not protect elderly with co-morbidities against disease symptoms caused by a coronavirus infection.

2 Feb 2023

WHO to launch council to accelerate the development of TB vaccine

The World Health Organization announces the creation of the TB Vaccine Accelerator Council.

20 Jan 2023

Exploring the immune mechanism induced by BCG vaccine in humanized mouse model

Announcing a new article publication for Zoonoses journal. This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by the Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model.

3 Jan 2023

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

What is the efficacy of the BCG vaccine against SARS-CoV-2 infection?

In a new study, researchers assessed the ecological association suggesting the efficacy of bacillus Calmette-Guerin (BCG) vaccination against COVID-19.

22 Sep 2022

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Researchers identified type 3 vaccine-derived poliovirus (VDPV) in an infant.

13 Sep 2022

The impact of the infant gut microbiome on vaccine efficacy

A new study reports the effect of the infant gut microbiome on vaccine efficacy.

13 Sep 2022

Modified TB vaccine could help treat non-muscle invasive bladder cancer

A modified tuberculosis (TB) vaccine developed at Texas Biomed could help treat a form of bladder cancer, called non-muscle invasive bladder cancer, without strong side effects.

22 Aug 2022

The BCG vaccine against COVID-19 and other infectious diseases in type 1 diabetic adults

A recent article demonstrated that BCG vaccinations might offer a platform for protection against emerging SARS-CoV-2 variants and other pathogenic infections in type 1 diabetics.

17 Aug 2022

BCG vaccine produces a "trained immunity response" which lasts more than a year

The immune boosting benefits of a tuberculosis vaccine can be seen in infants more than one year after vaccination, according to a new study.

8 Aug 2022

What does the future look like for TB care?

In this interview, we speak to Charles Wells from Gates MRI about their current research into tuberculosis (TB) as well as the recent updated guidelines for TB care.

5 Aug 2022

University of Oxford begins recruiting for Phase I trial of new TB vaccine

The University of Oxford has begun recruiting for a Phase I trial with a tuberculosis vaccine in human volunteers at Oxford to develop a new way to test the efficacy of future TB vaccines - with the first volunteers being challenged today (Wednesday).

12 Jul 2022

The effect of immunization with bivalent oral poliovirus vaccine on the incidence of COVID-19

Researchers evaluated the impact of the OPV on the incidence of COVID-19.

23 Jun 2022

Researchers reveal the mechanism of action of century-old BCG vaccine

The century-old Bacille Calmette-Guérin (BCG) vaccine against tuberculosis is one of the world's oldest and most widely used vaccines, used to immunize 100 million newborns every year. Given in countries with endemic TB, it has surprisingly been found to protect newborns and young infants against multiple bacterial and viral infections unrelated to TB. There's even some evidence that it can reduce severity of COVID-19.

4 May 2022

Study suggests BCG vaccination might confer immunity to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, the researchers investigated the impact of Bacillus Calmette-Guérin (BCG) vaccine-induced antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein.

25 Apr 2022

Study shows BCG vaccination reduces SARS-CoV-2-induced lung inflammation in hamsters

Researchers tested the effectiveness of the BCG vaccine in SARS-CoV-2-infected Syrian hamsters.

18 Mar 2022

The Future of Tuberculosis; An Interview with the Bill & Melinda Gates Medical Research Institute

We speak to Dr. Alemnew Dagnew from the Bill & Melinda Gates Medical Research Institute, about their tuberculosis vaccine study and the future of tuberculosis.

16 Mar 2022

Mice study shows how to improve long-term effectiveness of TB vaccine

Briefly blocking a key molecule when administering the only approved vaccine for tuberculosis vastly improves long-term protection against the devastating disease in mice, researchers from Texas Biomedical Research Institute report this week in the Journal of Immunology.

11 Mar 2022