Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Study reveals molecular control of tooth root formation and growth

Tooth root development relies on precise coordination of cellular signals, yet the underlying mechanisms remain unclear. Researchers have uncovered how two proteins, Gli2 and Gli3, work together to control signaling and differentiation in dental progenitor cells.

1 Apr 2026

New mechanism drives adverse tumor remodeling during breast cancer progression

A research group led by Professor Cecilia Sahlgren at Åbo Akademi University (Finland) and the InFLAMES Research Flagship has identified a new mechanism directing the adverse remodeling of tumor tissue during breast cancer progression.

18 Mar 2026

New method creates longer lasting CAR T cells for cancer therapy

A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments.

13 Mar 2026

Researchers discover protein that promotes natural dental pulp tissue regeneration

Dental pulp injury caused by trauma or deep caries often leads to inflammation, tissue necrosis, and eventual loss of tooth vitality.

10 Mar 2026

Targeting Wnt signaling to solve the dental pulp challenge

Dental pulp regeneration remains a major clinical challenge. Researchers have discovered that SMAD7 directly forms a transcriptional complex with β-catenin in human dental pulp stem cells, activating Wnt signaling and promoting regenerative gene expression.

9 Mar 2026

Gut microbiota-derived metabolite directly shapes immune responses in bacterial pneumonia

Sepsis and severe pneumonia are frequently accompanied by disruption of the gut microbiota, leading to immune dysfunction and increased susceptibility to secondary infections.

4 Mar 2026

New pathway found connecting liver congestion to fibrosis and cancer

Researchers from The University of Osaka find that chronic liver congestion is linked to severe liver diseases through a specific signaling pathway in liver sinusoidal endothelial cells - key cells lining the liver's tiny blood vessels.

27 Feb 2026

Identifying the core catalyst for muscle energy production

Researchers have investigated the role of a certain enzyme in regulating energy in muscle and exercise performance for decades, but a new study by Virginia Tech scientists has identified more precisely than ever how this mechanism works.

26 Feb 2026

Unexpected behavior observed during interactions between immune cells and dying cells

Over the years, cell biology has built a detailed picture of how cells compartmentalize their internal functions. Central to this organization is the nucleus, which houses the genetic material and is separated from the cytoplasm by a robust nuclear envelope.

25 Feb 2026

Multicolor electron microscopy reveals proteins and cell architecture at nanoscale resolution

Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the intricate architecture of cells and the specific locations of proteins-all in vivid color and at nanometer resolution.

22 Feb 2026

Engineered CAR-T cells reduce Alzheimer’s plaques in mice

Chimeric antigen receptor (CAR) T cell therapy, a type of immunotherapy that leverages the immune system to combat diseases, is a powerful treatment option for certain cancers.

9 Feb 2026

Brain immune cells regulate new neuron formation in adults

Breakthrough research from the University of Cincinnati College of Medicine is revealing how immune cells in the adult brain can regulate the generation of new neurons.

9 Feb 2026

Immune system dysfunction may fuel progressive heart failure after heart attacks

When the heart's muscle is weakened or injured due to a heart attack, it can make it hard for the heart to pump enough blood to meet the body's needs.

27 Jan 2026

Blood lipid–hormone ratios predict future asthma attacks years in advance

This study shows that specific ratios of circulating sphingolipids to steroids can predict the risk of future asthma exacerbations over five years with high discriminatory performance. By integrating metabolomics with longitudinal medical records, the research highlights lipid–hormone pathway imbalance as a key driver of asthma instability.

20 Jan 2026

Polyamines reshape protein phosphorylation to guide key cellular fate decisions

Polyamines are small molecules naturally present in all cells and are critical in guiding cellular decisions, whereas an alteration in the abundance of these metabolites is invariably observed in pathological scenarios such as cancer or aging.

14 Jan 2026

Research highlights a potential therapeutic strategy for vascular dementia

A possible new treatment for impaired brain blood flow and related dementias is on the horizon.

22 Dec 2025

Blood metabolite profiling outperforms BMI in predicting pregnancy complications

This study shows that a blood-based metabolomic signature linked to maternal BMI predicts gestational diabetes and preeclampsia more strongly than BMI alone, particularly in late pregnancy. A subset of 16 metabolites statistically mediates the BMI–gestational diabetes association, highlighting metabolic pathways that may improve prenatal risk stratification.

21 Dec 2025

Two compounds sourced from cannabis show promising anti-cancer effects

In the future, scientists could use drugs made from cannabis to fight ovarian cancer. A team of scientists testing the effects of two chemical compounds sourced from cannabis on ovarian cancer cells have found that both show promising anti-cancer effects.

15 Dec 2025

AI-driven method uncovers genetic interactions that fuel cancer progression

University of South Australia scientists have developed a powerful new way to uncover the genetic interactions that fuel cancer progression, paving the way for earlier and more precise treatments.

9 Dec 2025