Chromatin News and Research

RSS

Cells share universal on switches but evolve unique strategy to silence genes

The signals that cells use to switch genes on have remained almost unchanged across two billion years of evolution, but the ones used to switch genes off vary dramatically from one branch of life to another, according to a new study from the Centre for Genomic Regulation (CRG) in Barcelona.

3 Aug 2026

Sino Biological launches SuperNuclease® Pro with free trial program

Sino Biological, Inc., a global leader in recombinant technology, announced the launch of SuperNuclease® Pro (Cat#: SSNP02).

From Sino Biological Inc. 31 Jul 2026

Microbial metabolites could help improve functional cure rates for hepatitis B

Chronic hepatitis B (CHB) remains a major global challenge. Current therapies suppress HBV but rarely achieve functional cure (sustained HBsAg loss).

30 Jul 2026

Researchers identify key barrier preventing self repair of heart cells

Specialized cells in our body make biological tradeoffs to do certain jobs. To support large and hardworking hearts that power our other organs, our heart cells evolved to be extremely efficient and resilient.

28 Jul 2026

Study reveals how DNA misfolding causes congenital heart disease

Congenital heart disease is the most common birth defect, affecting approximately 1 in 100 babies born each year. One of the many causes for this disorder is having only one functional copy of the gene TBX5, instead of two healthy copies, inherited from parents.

23 Jul 2026

Researchers link genome folding to gene activity and brain tissue organization in Alzheimer's

Researchers from Carnegie Mellon University's School of Computer Science, the University of Pittsburgh School of Medicine and the University of Washington shed new light on Alzheimer's disease that could point to new directions for treatment.

23 Jul 2026

DNA enhancer hubs control cancer genes in prostate tumors

Enhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated.

22 Jul 2026

ECT-like brain stimulation triggers unexpected nuclear reprogramming in mature neurons

Nearly 90 years after Ugo Cerletti and Lucio Bini introduced electroconvulsive therapy (ECT), brain stimulation therapies such as ECT and Repetitive Transcranial Magnetic Stimulation (rTMS) are common in psychiatry because they are highly effective for treating depression and schizophrenia, yet their cellular mechanisms remain poorly understood

17 Jul 2026

Blocking ZFP384 protein extends brain repair window after stroke

Blocking the activity of ZFP384 can prolong the brain’s endogenous repair functions after stroke, report researchers in a collaborative study.

13 Jul 2026

New generation approaches revive BET protein inhibitors in solid tumors

BET proteins, especially BRD4, drive oncogenic transcription in solid tumours. First‑generation inhibitors (JQ1, molibresib, birabresib) showed preclinical promise but failed clinically due to modest efficacy, dose‑limiting thrombocytopenia, and resistance (isoform switching, compensatory PI3K/AKT/WNT signalling).

11 Jul 2026

Single cocaine exposure causes lasting brain cell changes in mice

Researchers studying the impact of cocaine in mice have found that just one exposure to the drug can create changes in brain cells that persist for at least two weeks.

6 Jul 2026

Memory B cells reveal how nasal vaccines could stop respiratory infections earlier

A Science Immunology Review explains how memory B cells acquire diverse molecular, epigenetic, and tissue-specific programs that shape long-term immune protection. It highlights lung-resident memory B cells as a key target for mucosal vaccines, potentially improving control of airborne infections and reducing transmission.

6 Jul 2026

New method helps scientists better understand DNA organization

Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at NUS have developed a new method that allows scientists to better understand how DNA is organized and regulated inside our cells.

6 Jul 2026

Study potential new therapeutic strategy for patients with ATRX-mutant gliomas

A new study from researchers at The University of Texas MD Anderson Cancer Center has uncovered how one of the most common genetic alterations in glioma rewires the cancer cell genome to fuel tumor progression, suggesting a potential new therapeutic strategy for patients with ATRX-mutant gliomas.

1 Jul 2026

SickKids study uncovers cell recovery mechanisms linked to stomach cancer

Few areas of the body face more daily stress and potential damage than the stomach, which must manage everything we swallow.

30 Jun 2026

Gut microbes emerge as potential players in estrogen-driven cancers

A new review maps how the endocrine-microbiome axis expands the estrobolome concept, showing that gut microbes may alter estrogen recycling, produce hormone-like metabolites, and shape inflammation and tissue environments in hormone-driven cancers. Human evidence remains mostly associative, so the authors call for causal models, longitudinal multi-omics, multi-kingdom profiling, and sex-stratified studies before microbiome-guided cancer strategies enter routine care.

25 Jun 2026

Study discovers epigenetic mechanism protecting tooth progenitor cells from stress

An epigenetic "mechanostat" has been discovered that protects tooth-forming progenitor cells from mechanical stress and supports lifelong tissue renewal.

19 Jun 2026

Key Alzheimer's protein actively protects neurons from nuclear damage

Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP), a molecule long studied as the precursor to amyloid-β (Aβ) in Alzheimer's disease (AD).

17 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026

Low-methionine diet shows promise against aggressive brain tumors

An unexpected lab observation led a team of scientists to discover how diet can influence survival in animal models of glioma, one of the most aggressive and deadly forms of brain cancer.

10 Jun 2026