Exhaustion News and Research

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Lactate and lactylation play multifaceted roles in pancreatic ductal adenocarcinoma

A comprehensive review recently published in Current Molecular Pharmacology illuminates the pivotal, multifaceted roles of lactate and its downstream protein modification, lactylation, in pancreatic ductal adenocarcinoma (PDAC).

25 Jun 2026

Study reveals early immune clues to predict active tuberculosis risk

An early view of the immune response to bacteria in the lungs provides clues as to why some people keep TB in check, while others develop disease, suggesting new ways to intervene earlier and stop TB.

24 Jun 2026

Aging immune cells may explain why autoimmunity rises later in life

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.

21 Jun 2026

Indiana University researchers investigate immune cell aging in Parkinson's disease

A new cutting-edge research team, led by Indiana University School of Medicine scientists and interdisciplinary experts from multiple universities, will investigate the role of immune cell aging on Parkinson's disease risk and progression.

18 Jun 2026

First human trial targets aging immune cells for healthier immunity

A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells is expected to begin later this year, building on research led by UCL scientists into the mechanisms of immune aging.

17 Jun 2026

JMIR articles address AI clinical decision-making and health care worker burnout

JMIR Publications released two feature stories in its News and Perspectives section. Shalini Kathuria Narang's "Can Humanlike Reasoning Be Replicated in Large Language Models for Clinical Decision-Making?" and Sara Novak's "How Health Care Workers Can Manage Digital Fatigue" offer complementary looks into the capabilities of artificial intelligence in diagnostics, and the real-world exhaustion faced by medical professionals managing digital systems.

16 Jun 2026

Review highlights TIGIT as a promising second-generation immunotherapy target

Malignant tumors remain a major threat to human health, with conventional therapies and first-generation immune checkpoint inhibitors (ICIs) facing limitations like drug resistance and low response rates.

5 Jun 2026

Modified stem cell therapy reverses new-onset Type 1 diabetes in mice

A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease.

2 Jun 2026

Gay dating apps during travel bring connection and emotional fatigue

New research shows that gay dating apps during travel can bring excitement and connection - but also emotional exhaustion, catfishing, and vulnerability.

25 May 2026

Sting signaling stimulates vital immune defenses to actively suppress aggressive tumor growth

A new review brings attention to the STING pathway as a critical regulator in both colitis and colon cancer, highlighting its complex and often opposing roles in inflammation and tumor development. The findings underscore how this key component of the innate immune system can act as both a driver of disease and a protective mechanism, depending on biological context.

25 May 2026

Study identifies major causes of fatigue among disaster responders

Real time data collected during the 2024 Noto Peninsula earthquake response show that unclear tasks and command structures, and lack of meal- and rest breaks increased self-reported fatigue among disaster responders.

22 May 2026

Small T-cell subset drives powerful multiple myeloma immunotherapy responses

Researchers from The University of Osaka find that only a small fraction of T cells may drive the robust anti-cancer response seen in breakthrough multiple myeloma immunotherapy.

21 May 2026

Precision calcium signaling control may improve future CAR-T therapies

Calcium is widely known for its role in maintaining strong bones and teeth, but it is also one of the body's most important cellular messengers.

19 May 2026

New therapies could help type 1 diabetes care move beyond insulin alone

Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.

18 May 2026

Thyroid hormone profiles provide critical prognostic clues for patients facing liver failure

Early and accurate prognostic assessment is crucial to prevent disease progression in liver failure. Thyroid hormones (THs), particularly triiodothyronine (T3), are key metabolic regulators and play an important role in liver regeneration. Liver failure is frequently complicated by non‑thyroidal illness syndrome (NTIS), characterized by low T3 with normal or slightly elevated TSH and T4.

14 May 2026

Study: One in ten babies regularly falls asleep with a screen

Despite recent government guidelines that parents should avoid screen time for babies under the age of two, a new global study finds that one in ten babies now regularly fall asleep with a screen.

4 May 2026

Impaired protein recycling drives T cell exhaustion in cancer

T cells are crucial components of our immune system, serving as critical protectors against infection and disease.

30 Apr 2026

From killers to strategists: CAR T cells enter their multifunctional era

A review of 1,801 registered CAR T clinical trials shows that multifunctional designs now account for 533 trials and 33% of new CAR T products submitted for clinical testing in 2025. The field is shifting toward multitargeted, safety-controlled, cytokine-secreting, and checkpoint-modulating CAR T cells, but manufacturing, regulation, and limited clinical outcome data remain key barriers.

30 Apr 2026

Single-cell sequencing reveals why some CAR-T therapies succeed while others fail

Single-cell RNA sequencing is giving researchers a clearer view of why some CAR-T cells persist, expand, kill tumors effectively, or become exhausted. The review synthesizes 44 clinical scRNA-seq studies involving 500 patients and highlights how exhaustion, memory, cytotoxicity, clonal diversity, and metabolism may shape CAR-T responses.

30 Apr 2026

Metabolic rewiring could help CAR-T cells fight solid tumors

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells inside solid tumors. It highlights metabolic reprogramming as a promising strategy to improve CAR-T cell persistence, adaptability, and anti-tumor function.

29 Apr 2026