FRET News and Research

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New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Researchers reported on Nurr1 as a promising therapeutic target for managing Parkinson's disease (PD).

20 Jul 2023

Study shows promising prospects for automating 3D-DSRT in drug testing

The June 2023 issue of SLAS Discovery contains one review article, five full-length articles and two technical briefs covering spheroid models, 3D cell high-throughput screening (HTS) applications for treating Alzheimer's and other drug discovery research.

29 Jun 2023

Medi-Cal enrollees in California: Here’s how to verify your eligibility

If you are enrolled in Medi-Cal, as more than one-third of Californians are, make sure your county knows how to reach you, or you could lose your health coverage unnecessarily.

8 May 2023

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Cell membranes play a critical role by serving as containment units and separating the inner cellular space from the extracellular environment.

26 Apr 2023

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Researchers examined molecular-level differences in ribosomal translational fidelity between humans and bacteria.

7 Apr 2023

Next-gen Mpro inhibitor: Promising new drug candidate against Omicron and other SARS-CoV-2 variants

A recent Nature Signal Transduction and Targeted Therapy journal study demonstrated the potential antiviral activity of a new Mpro inhibitor (SY110) against SARS-CoV-2 Omicron and its sublineages.

21 Mar 2023

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

16 Mar 2023

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

27 Jan 2023

New imaging system reveals how female and male hearts respond differently to stress hormone

A new study published in Science Advances shows female and male hearts respond differently to the stress hormone noradrenaline.

23 Jan 2023

Artemisia argyi plant extracts and phytochemicals shown to inhibit SARS-CoV-2 in new research

Researchers reported that Artemisia argyi extracts and phytochemicals could inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Jan 2023

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

20 Dec 2022

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Necroptosis is a form of regulated cell death (RCD) similar to apoptosis, the most commonly studied type of RCD. In contrast to apoptosis, plasma membrane rupture in necroptotic cells occurs at early time points.

9 Dec 2022

Scientists move a step closer to advancing personalized cancer treatment

In a step likely to advance personalized cancer treatment, scientists have for the first time shown in patients that levels of biomarkers are not enough to tell which patients are likely to respond best to immunotherapy.

22 Nov 2022

The potential of nanobody engineering in the development of SARS-CoV-2 antivirals and diagnostic tools

Researchers investigated nanobody engineering to develop antivirals and diagnostic tools against SARS-CoV-2.

20 Sep 2022

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

In a recent study posted to the bioRxiv* preprint server, researchers from Spain, the United Kingdom, and the United States used chemical tools to uncover the molecular details of glycan-mediated modulation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) processing.

19 Sep 2022

Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Huntington's disease (HD) is a hereditary brain disease caused by a mutation in the huntingtin gene. HD is a neurodegenerative disease without a cure that, after the onset of the disease at around 40 years of age, causes changes in personality and symptoms of dementia along with uncontrollable convulsive movements, ultimately leading to death.

19 Sep 2022

FRET News and Research

New brain-penetrant agonist shows promise in protecting dopamine neurons for Parkinson's disease treatment

Study shows promising prospects for automating 3D-DSRT in drug testing

Medi-Cal enrollees in California: Here’s how to verify your eligibility

Study reveals the mechanism behind oligomeric assembly of a BAR-domain-containing protein

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Next-gen Mpro inhibitor: Promising new drug candidate against Omicron and other SARS-CoV-2 variants

Scientists discover mechanism used by cancer cells to repair DNA damage induced by radiotherapy

A high-throughput screening assay for small molecule inhibitors of the antigen aminopeptidase ERAP1

New imaging system reveals how female and male hearts respond differently to stress hormone

Artemisia argyi plant extracts and phytochemicals shown to inhibit SARS-CoV-2 in new research

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Researchers develop transgenic mice with the FRET biosensor for in vivo observation of necroptosis

Scientists move a step closer to advancing personalized cancer treatment

The potential of nanobody engineering in the development of SARS-CoV-2 antivirals and diagnostic tools

O-linked sialoglycans affect SARS-CoV-2 spike cleavage

Study reveals pathological mechanisms of synaptic dysfunction in patients with Huntington's disease

Cell Counting Without Slides to Reduce Waste and Cost

Assessing immunization capacity of vaccine platforms with DNA origami harboring SARS-CoV-2 receptor binding domain

Study suggests peimine may be a potent inhibitor of SARS-CoV-2 variant infection

Cross-validation of distance measurements in motile proteins reveals certain inconsistencies

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Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics