Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Paternal sperm epigenetics may help explain early pregnancy loss

When a pregnancy ends early and unexplained, the search for answers usually begins with the mother. Lacey Luense, Ph.D., wants to know what the father's sperm might have to do with it.

28 Aug 2026

Stanford scientists develop an ultracompact gene activation tool

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

28 Aug 2026

Cell proliferation gene plays a distinct role in cells that no longer proliferate

In a tale of identities as divergent as "The Prince and the Pauper," a well-known cancer-causing gene also influences cells in a zombie-like state meant to prevent cancer.

28 Aug 2026

Machine learning maps changing immune response over time in sepsis

Researchers have mapped how the immune response in people with sepsis changes over time.

28 Aug 2026

Compound PF-04457845 slows motor decline in ALS mouse models

Amyotrophic lateral sclerosis (ALS) is a severe neurological disease that destroys nerve cells responsible for muscle movement.

28 Aug 2026

Stress gene switches on more easily in the brains of people with schizophrenia

Experts at the University of Sydney have found that a gene involved in regulating the body's response to stress switches on more easily in the brains of people who live with schizophrenia.

26 Aug 2026

Nicoya is a famous blue zone. DNA aging estimates tell a more complicated story

Researchers developed a SuperLearner framework that combines established epigenetic clocks with machine learning to compare DNA methylation-based aging in residents of Costa Rica’s Nicoya Blue Zone with other Costa Ricans. Initial calibration suggested a modest younger epigenetic age among Nicoyans, but accounting more closely for age distribution substantially reduced the apparent advantage, highlighting the importance of population-specific calibration in longevity research.

26 Aug 2026

From caffeine to trigonelline, coffee has surprising links to muscle biology

A scoping review of 54 studies found that coffee and several coffee-derived bioactive compounds influence pathways linked to skeletal muscle metabolism, including insulin signaling, mitochondrial function, oxidative stress, inflammation, glucose uptake, and protein turnover. Human studies reported associations with greater muscle mass and lower frailty or functional impairment, but most evidence remains observational or preclinical and cannot establish causality.

25 Aug 2026

Scientists compared 51 longevity studies to see which aging biomarkers respond most reliably

Researchers analyzing 51 longitudinal intervention studies found that reliable generation 2+ DNA methylation biomarkers, particularly those predicting mortality or pace of aging, were the most responsive to interventions aimed at longevity or healthspan. Pharmacological and lifestyle interventions produced the strongest biomarker changes, but the authors cautioned that responsiveness does not yet establish these measures as validated surrogate endpoints for slower aging or longer life.

25 Aug 2026

Targeting cyclin-dependent kinases offers new pathways for cancer therapy

Cancer is the second leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent kinases (CDKs) has come into focus.

24 Aug 2026

New study makes progress in understanding the mechanisms behind severity of HFpEF

Approximately 3 million people in the United States are living with a condition called heart failure with preserved ejection fraction, or HFpEF.

24 Aug 2026

Disrupted brain-immune signaling may help drive neurodegeneration

A Cell perspective argues that neurodegeneration can emerge from disrupted communication between neural and immune networks, with peripheral immunity, microglia, and gene-regulatory programs all shaping disease processes. The authors propose that restoring immune homeostasis and recalibrating neuroimmune circuits could create new therapeutic and diagnostic opportunities, while emphasizing that many mechanisms remain unresolved in humans.

24 Aug 2026

New AI model reveals hidden code behind gene activation

Precise activation of tens of thousands of genes is critical for healthy development and growth. Specialized segments of our DNA are responsible for carefully orchestrating genetic sequences that result in the production of enzymes, hormones, proteins and other crucial components underlying cell structure and function.

21 Aug 2026

New 3D mapping technology reveals how hair follicles form over time

In a new research report, scientists at Johns Hopkins Medicine say they have developed a technology that allows them to capture a 3D molecular "snapshot" of hundreds of hair follicles as they develop and then reconstruct the fourth dimension - time - to effectively create a stop-motion animation of how this organ forms.

21 Aug 2026

Bonsai software visualizes complex biological data as branching trees

Modern biology research can now generate valuable data on an unprecedented scale. But there is one major obstacle: making sense of these complex high-dimensional datasets.

21 Aug 2026

Researchers map DNA's physical code using large-scale simulations

Nearly every cell in the human body contains essentially the same genetic information, yet different cells activate different genes. For regulatory proteins to reach these genes, DNA must be accessible.

20 Aug 2026

Microglial differences found in genetic and sporadic frontotemporal dementia patients

A study by the University of Eastern Finland revealed for the first time clear differences in the function and gene expression of microglial cells from patients with genetic and sporadic types of frontotemporal dementia.

20 Aug 2026

Researchers develop new tool to estimate a cell's biological age

Researchers at Karolinska Institutet and Stockholm University have developed a new tool that estimates a cell's biological age by analyzing its gene activity.

18 Aug 2026

Deep-learning tissue clocks reveal how organs age and leave disease-linked signals in blood

Deep learning applied to more than 25,000 histopathology slides revealed tissue-specific structural signatures of biological aging that tracked telomere attrition, pathology, comorbidity, and molecular changes more closely than chronological age alone.

18 Aug 2026