Gluconeogenesis News and Research

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Gluconeogenesis (abbreviated GNG) is a metabolic pathway that results in the generation of glucose from non-carbohydrate carbon substrates such as lactate, glycerol, and glucogenic amino acids.

Gut microbiome and brain evolution: New insights into energy allocation

Gut microbiota from primates with larger brains promotes glucose production and energy allocation for brain function, shedding light on metabolic strategies in evolution.

4 Dec 2024

Targeting intracellular checkpoints to enhance NK cell immunotherapy

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

27 Nov 2024

How alcohol impacts male health

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, emphasizing the complex mechanisms and public health implications.

18 Nov 2024

Brazilian research uncovers how liver nerves regulate glucose production under stress

A study led by Brazilian researchers has produced a detailed description of the morphology of the nerves in the liver and how they control production of glucose when the organism is under stress.

11 Sep 2024

Gut bacteria pathways directly linked to insomnia risk identified

Study uncovers a causal link between specific gut microbiome metabolic pathways and insomnia, highlighting potential therapeutic targets for improving sleep quality.

3 Sep 2024

How short-term nighttime carb restriction boosts exercise and burns fat

Dietary modifications, like the sleep-low method, may improve exercise performance by optimizing glycogen storage and fat metabolism. A study in Nutrients shows night-time carbohydrate restriction benefits endurance and weight management.

10 Jul 2024

Innovative therapeutic strategies for combating type 2 diabetes

One of the most confusing aspects for patients with type 2 diabetes mellitus is that they have high fasting glucose levels.

7 Jun 2024

Research reveals light's impact on metabolism beyond circadian rhythms

A recent Nature Metabolism review highlights how light exposure or deprivation affects metabolic activities like thermogenesis and glucose homeostasis through non-circadian pathways.

4 Jun 2024

Intermittent fasting halts liver disease progression and reduces cancer risk

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.

8 May 2024

Cinnamon, curcumin, and resveratrol show promise in diabetes inflammation fight

Researchers reviewed the impact of cinnamon, curcumin, and resveratrol on oxidative stress and inflammation in type 2 diabetes patients, highlighting their potential to improve metabolic regulation and reduce complications.

26 Apr 2024

Study may open up new ways of approaching metabolic diseases

A study led by the University of Barcelona and the Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM) reveals how a new mechanism could improve the efficiency of currently available treatments for diabetes.

12 Feb 2024

Study reveals key mechanism behind obesity-related metabolic dysfunction

Researchers found that feeding a high-fat diet (HFD) causes mitochondrial dysfunction and fragmentation in white adipocytes in mice.

31 Jan 2024

D-alanine linked to gluconeogenesis in the kidney and circadian clock

Only recently was it discovered that amino acids, the building blocks of proteins, exist in two different forms: L- and D-forms.

21 Dec 2023

Sympathetic nervous system and immune interplay: Key to metabolic regulation

A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. This comprehensive analysis provides insights into the neuroimmune relationships affecting metabolism, offering potential new therapeutic strategies for metabolic diseases.

5 Dec 2023

The future of functional foods: Leveraging Dendrobium officinale for optimal gut health and disease prevention

The structure, extraction, health benefits, and mechanisms of Dendrobium officinale polysaccharides (DOPs).

27 Nov 2023

Saliva analysis breakthrough: Detecting cognitive decline stages in Parkinson’s patients

Researchers used integrative metaproteogenomic analysis to show that changes in salivary microbiota and biomolecules can indicate cognitive impairment stages in Parkinson’s disease patients, offering a potential diagnostic tool.

23 Nov 2023

Citrus compounds show zesty promise in type 2 diabetes management

Citrus compounds show promise in type 2 diabetes management, reducing blood glucose and mitigating metabolic complications without a clear threshold in humans for bioflavonoid efficacy.

2 Nov 2023

How is TikTok's #Ozempic trend impacting diabetes patients?

A recent study analyzed TikTok videos with the hashtag "Ozempic," highlighting the platform's influence on promoting the weight loss drug. The surge in popularity resulted in medication shortages for diabetes patients, emphasizing the need for careful monitoring and collaboration among health professionals and social media platforms.

5 Oct 2023