Histopathology News and Research

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Study reveals how Ebola and Marburg viruses damage the human gut

Ebola (EBOV) and Marburg virus (MARV) are highly lethal viruses that cause severe disease in infected patients by extensively damaging the body.

11 Dec 2025

AI analysis of biopsy slides predicts rectal cancer treatment response

Artificial intelligence (AI) can predict how well patients with rectal cancer will respond to treatment by analyzing standard tissue samples taken during diagnosis, finds a new study from researchers at UCL and UCLH.

19 Nov 2025

Switching APOE4 to APOE2 in adult mice reduces Alzheimer’s pathology and improves memory

Replacing APOE4 with APOE2 in adult mice rapidly reshapes brain lipids and gene expression, even after development is complete. This switch, especially when targeted to astrocytes, reduces amyloid burden, dampens gliosis, and improves associative memory despite E2-like peripheral lipid risks.

12 Nov 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

AGA updates guidelines for Barrett's Esophagus to catch cancer early

The American Gastroenterological Association (AGA) released a new clinical practice guideline on the surveillance of Barrett's esophagus, the only known precursor to esophageal cancer (adenocarcinoma), a highly lethal cancer whose incidence has risen substantially over recent decades.

21 Oct 2025

New guidelines for managing interstitial lung disease associated with connective tissue diseases

EULAR - The European Alliance of Associations for Rheumatology - has worked with the European Respiratory Society (ERS) to develop new clinical practice guidelines for interstitial lung disease (ILD) associated with connective tissue diseases (CTD).

5 Sep 2025

Neuritin 1 unlocks new pathway to treat obesity without reducing food intake

Is it possible to treat obesity without reducing food intake? A new study co-led by Dr. Antonio Zorzano and Dr. Manuela Sánchez-Feutrie at the Institute for Research in Biomedicine (IRB Barcelona) suggests that this might be a possibility, at least in animal models.

4 Sep 2025

PathoPlex technology maps protein patterns across human organs

Each organ in the human body contains different types of cells arranged in specific ways.

19 Aug 2025

Blocking CREB may prevent alcohol-related pancreatic cancer

Despite increasing evidence linking alcohol consumption to cancer, little is known about the biological mechanisms behind the association.

12 Aug 2025

ATR FTIR spectroscopy shows high accuracy in breast tissue classification

Histopathology is the gold standard in cancer diagnosis. However, attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) spectroscopy has shown diagnostic potential in other settings.

18 Jul 2025

Nasal antibody spray shields mice from pollen-triggered allergies and asthma

Intranasal delivery of a monoclonal IgG1 antibody targeting mugwort pollen protected mice from allergic rhinitis and asthma symptoms, without lowering systemic IgE levels. This localized, non-invasive approach dampened Th2 inflammation and preserved healthy airway tissue in sensitized mice.

14 Jul 2025

Novel AI application diagnoses endocrine cancers with speed and accuracy

A novel artificial intelligence (AI) application capable of diagnosing endocrine cancers with speed and accuracy is being presented Sunday at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

13 Jul 2025

Gut microbe emerges as a promising tool in the fight against COVID-19

Researchers found that Akkermansia muciniphila boosts lung-specific antiviral immunity against SARS-CoV-2 in mice by modulating the gut–lung axis. This commensal gut bacterium shows promise as a potential biomarker and biotherapeutic candidate for COVID-19 and other respiratory infections.

25 Jun 2025

AI agent shows promise to support oncologists in everyday clinical practice

Clinical decision-making in oncology is challenging and requires the analysis of various data types – from medical imaging and genetic information to patient records and treatment guidelines.

6 Jun 2025

Sapio Sciences appoints Gordon McCall as Chief Operating Officer to drive global operational excellence

Sapio Sciences, the science-aware™ lab informatics platform, today announced the promotion of Gordon McCall to Chief Operating Officer (COO).

From Sapio Sciences 28 May 2025

Discovery unravels two populations of gonadotrophs in the pituitary gland

Researchers at the Francis Crick Institute have shown that gonadotrophs, cells in the pituitary gland with a key role in puberty and reproduction, come from two different populations, with the majority produced after birth rather than in the embryo, as previously thought.

21 May 2025

Sapio Sciences introduces Biorepository Management solution in Sapio Release 25.4

Sapio Sciences, the science-aware™ lab informatics platform, today announced Sapio Release 25.4, introducing a new Biorepository Management solution, enhanced sample management capabilities, and platform-wide enhancements designed to streamline lab operations and support high-throughput research environments.

From Sapio Sciences 2 May 2025

Understanding the complex spectrum of Castleman disease

Castleman disease (CD) is a rare, non-clonal lymphoproliferative disorder that manifests with a wide range of histologic and clinical features.

11 Apr 2025

Source Bioscience acquires Cambridge Clinical Laboratories

Source BioScience UK Ltd, an industry-leading provider of genomic services and histopathology diagnostics, today announced it had completed the acquisition of Cambridge Clinical Laboratories (CCL), a leading Cambridge-based provider of clinical, personalized healthcare testing services.

10 Apr 2025

Uncommon ovarian tumors detected in a single patient

A new case report was published in Oncoscience's Volume 12 on March 31, 2025, titled "Cystadenofibroma and contralateral collision lesions: A unique ovarian case report."

4 Apr 2025