Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

AI model predicts effective immunotherapy combinations for liver cancer

Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to predict which patients with a primary liver cancer called hepatocellular carcinoma (HCC) would most benefit from combination treatment using immunotherapy and a targeted therapy that blocks the growth signals that the tumor depends on.

15 Jul 2026

Integrating gene signatures and multi omics improves liver cancer treatment

Hepatocellular carcinoma (HCC) remains highly fatal due to late diagnosis and scarce early biomarkers.

14 Jul 2026

Robot-guided surgery successfully drains multiple deep brain abscesses

Brain abscesses located deep within the brain can rapidly become life-threatening and are often difficult to treat through conventional surgery. Brain abscesses located deep within the brain can rapidly become life-threatening and are often difficult to treat through conventional surgery.

13 Jul 2026

New stem cell approach targets functional cure for diabetes

New research presented today at the International Society for Stem Cell Research (ISSCR) 2026 Annual Meeting explores an approach that could expand the potential of cell replacement therapy for type 1 diabetes by evaluating whether immune-engineered, allogeneic insulin-producing cells can survive and function without chronic immunosuppression.

11 Jul 2026

Clinical trial finds stem cell brain transplants feasible for Parkinson's disease

A landmark study led from Lund, Sweden, has shown that transplanting stem-cell derived dopamine progenitor cells into the brain is feasible.

9 Jul 2026

Reversing macrophage metabolism may improve cancer immunotherapy outcomes

Tumor-associated macrophages (TAMs) are among the most abundant immune cells in the tumor microenvironment.

1 Jul 2026

Study links severe COVID to higher TB risk, and vaccination appears to blunt the link

A nationwide Chilean cohort study of more than 3.6 million adults found that severe COVID-19 requiring hospitalization was associated with more than an eightfold higher hazard of incident tuberculosis within one year. The association was strongest in the first six months and among unvaccinated individuals, although absolute TB incidence remained low.

1 Jul 2026

Peacemaker immune cells offer new hope for restoring immune tolerance

'Peacemaker' immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science.

25 Jun 2026

Immunotherapy helps bridge cancer patients to curative liver transplantation

Liver transplantation remains one of the most powerful curative options for hepatocellular carcinoma (HCC) because it removes both the tumor and the diseased liver.

22 Jun 2026

Novel gene therapy appears to be safe for Friedreich ataxia cardiomyopathy

A new gene therapy appears to be safe in patients diagnosed with Friedreich ataxia cardiomyopathy, a progressive and fatal inherited cardiac disease, according to a phase 1 clinical trial led by Weill Cornell Medicine researchers.

17 Jun 2026

Researchers uncover immune loop driving Sjögren's disease progression

Sjögren's disease is a widespread chronic autoimmune disorder that attacks the body's own glands, yet its underlying disease mechanisms remain poorly understood.

10 Jun 2026

Trial shows safety of TTV-guided immunosuppression in kidney transplant recipients

An international research team coordinated by the Medical University of Vienna has demonstrated in a clinical trial that Torque-Teno-virus-guided dosing of immunosuppressants in kidney transplant recipients is safe.

8 Jun 2026

New technique protects pancreatic islet transplants without immunosuppressive drugs

Type 1 diabetes (T1D) is a lifelong autoimmune disorder where the immune system attacks islets, certain areas of the pancreas, and destroys cells that would otherwise produce insulin, a hormone crucial for regulating blood sugar levels.

3 Jun 2026

CAR-T cell therapy shows promise for treating rheumatoid arthritis

Current therapies for rheumatoid arthritis rely on sustained immunosuppression rather than restoration of immune tolerance, with off-drug remission remaining rare.

3 Jun 2026

Review explores complex associations between sleep apnea and lung cancer

Obstructive sleep apnea (OSA) is a common sleep disorder characterized by intermittent hypoxia and sleep fragmentation, which may contribute to lung cancer development and progression.

29 May 2026

Engineered regulatory T cells offer a path toward immunosuppression-free transplants

Organ transplantation remains the cornerstone treatment for end-stage organ failure. While conventional broad-spectrum immunosuppression effectively controls acute rejection, it fails to address chronic rejection and carries long-term side effects including infection, malignancy, and metabolic disorders.

8 May 2026

Researchers uncover new mechanism linking metabolism, immunity, and skeletal health

Obesity alters bone health not only through increased body weight but also by reshaping the bone marrow environment.

25 Apr 2026

"Domino" heart valves from diseased organs could save thousands of children

A surgical innovation called partial heart transplantation could transform care for children with severe heart valve disease, allowing for thousands of additional valve transplants each year, according to a presentation delivered today by Joseph Turek, MD, PhD, at the International Society for Heart and Lung Transplantation (ISHLT) 46th Annual Meeting and Scientific Sessions.

24 Apr 2026

Hyperbaric oxygen therapy shows dual effects in glioblastoma treatment

Glioblastoma remains a highly challenging malignancy with a pronounced tendency for recurrence. The hypoxic microenvironment is a key contributor to its therapy resistance.

23 Apr 2026

Cystic fibrosis therapies significantly reduce the need for pediatric lung transplants

Pediatric lung transplant specialist Christian Benden, MD, described the future for children who need lung transplants: fewer operations overall, but more complex patients and mounting challenges for the teams who care for them. He addressed the 46th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT) today in Toronto.

22 Apr 2026