Interferon News and Research

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Targeting CMPK2-intervened redox metabolism to mitigate hepatic ischemia-reperfusion injury

HIRI is a major clinical challenge that occurs when blood supply to the liver is temporarily interrupted and then restored, as commonly seen in liver resection and liver transplantation.

16 Jul 2026

Researchers uncover new T cell attack mechanism against acute myeloid leukemia

Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide the development of future cancer immunotherapies.

15 Jul 2026

Dysregulation of immune regulator NF-κB drives major human diseases

NF‑κB controls genes involved in inflammation, immunity, cell survival, and proliferation. Triggered by cytokines (TNF‑α, IL‑1β), microbial products, or cellular stress, it translocates to the nucleus and induces pro‑inflammatory mediators.

13 Jul 2026

New viral library helps scientists study thousands of proteins

To prevent viruses from sickening or killing us - whether it's an individual case of hepatitis B or a COVID pandemic - it's crucial to understand how the proteins they make initiate changes in our bodies that allow them to flourish.

11 Jul 2026

Maternal diet may subtly shape breast milk immune signals

Research indicates that maternal dietary patterns can subtly affect the immune composition of breast milk, with implications for infant immune development.

9 Jul 2026

Study offers insight into how long-term inflammation may contribute to cognitive decline

The King's College London study, published in Nature Communications, offers insight into how long-term inflammation may contribute to cognitive decline in disorders such as Alzheimer's disease, aging, depression, and the lingering neurological effects of viral infections.

7 Jul 2026

Memory B cells reveal how nasal vaccines could stop respiratory infections earlier

A Science Immunology Review explains how memory B cells acquire diverse molecular, epigenetic, and tissue-specific programs that shape long-term immune protection. It highlights lung-resident memory B cells as a key target for mucosal vaccines, potentially improving control of airborne infections and reducing transmission.

6 Jul 2026

Feeder-free TIL expansion system makes advanced cancer immunotherapy safer

Conventional TIL therapy, clinically validatedrecently with the U.S. Food and Drug Administration approval of lifileucel for advanced melanoma,stillfaces substantial hurdles.

3 Jul 2026

Probiotic metabolite found to suppress melanoma tumor growth in mice

Immune checkpoint inhibitors like anti-PD-1 have transformed melanoma treatment, yet more than half of patients fail to respond or eventually develop resistance.

30 Jun 2026

Nasal viruses may drive allergic rhinitis, and ribavirin shows early promise as a targeted spray treatment

Nasal commensal viruses may worsen allergic rhinitis by activating type I IFN-linked neutrophils and NET formation. Ribavirin reduced nasal viral abundance and improved symptoms in mice and in a small phase 2 trial.

28 Jun 2026

Exercise, not liraglutide alone, drives vascular gains after obesity-related weight loss

A prespecified secondary analysis of the S-LiTE trial found that regular exercise reduced carotid artery wall thickness and circulating levels of inflammatory cytokines in adults with obesity who had already achieved substantial diet-induced weight loss. Liraglutide alone did not significantly improve these vascular or inflammatory markers, while exercise plus liraglutide also improved endothelial function biomarkers.

25 Jun 2026

New biomarkers identify trauma patients at risk for chronic critical illness

New research, published in The Journal of Immunology, identified biomarkers of a distinct immune profile that could be used to identify patients at risk for chronic critical illness (CCI) upon admittance to the intensive-care unit (ICU) after traumatic injury.

25 Jun 2026

Scientists map genetic changes controlling the immune sensor STING

The immune system depends on molecular alarms that detect danger inside cells. One of these alarms is STING, short for "stimulator of interferon genes".

24 Jun 2026

Study reveals early immune clues to predict active tuberculosis risk

An early view of the immune response to bacteria in the lungs provides clues as to why some people keep TB in check, while others develop disease, suggesting new ways to intervene earlier and stop TB.

24 Jun 2026

Neutrophils reduce the effectiveness of cancer immunotherapy in mice

A type of white blood cell in the immune system, known as neutrophils, can make cancer immunotherapy less effective. This is shown in a new study from Karolinska Institutet published in the journal Immunity.

15 Jun 2026

A hidden immune pathway may help explain why Alzheimer’s inflammation persists

Researchers found that KAT7 promotes CMPK2-driven mitochondrial DNA release in microglia, activating inflammatory cGAS-STING and NLRP3 pathways linked to Alzheimer’s disease.

11 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026