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Hearing loss and sex shape dual-task outcomes in older adults with mild cognitive impairment

Cognitive and physical training can help older adults with mild cognitive impairment (MCI) maintain or improve their ability to move and think simultaneously, but hearing ability and sex influence outcomes, according to a new Concordia-led study.

7 Apr 2026

NOX-1 identified as key molecular target to prolong ketamine's antidepressant effects

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers rapid relief, its antidepressant effects fade within a few weeks.

30 Mar 2026

Study finds common brain mechanism behind different anesthesia drugs

When patients undergo general anesthesia, doctors can choose among several drugs. Although each of these drugs acts on neurons in different ways, they all lead to the same result: a disruption of the brain's balance between stability and excitability, according to a new MIT study.

17 Mar 2026

PET imaging reveals molecular mechanism behind ketamine's antidepressant effects

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond adequately to conventional antidepressant therapies.

6 Mar 2026

Enhancing myelination may help sustain therapeutic effects of psychedelic-assisted PTSD treatment

Post-traumatic stress disorder (PTSD) is not only characterized by strongly encoded traumatic memories, but also by disrupted coordination across brain networks.

4 Mar 2026

Breathing patterns and brain activity become more independent during the deepest sleep

Could the deepest parts of the brain hold some of the secrets of sleep that still remain elusive to science?

4 Mar 2026

Study finds around six nightclub deaths occur annually in the UK

Around 6 deaths a year are linked to clubbing in the UK, finds a 15 year retrospective study published online in Emergency Medicine Journal.

4 Mar 2026

Psychedelic effects of ketamine do not predict sobriety

The psychedelic effects recreational users often seek from taking ketamine do not predict the therapeutic benefits for people being treated for alcohol use disorder.

16 Feb 2026

HHCM awards $566K to advance psychedelic end-of-life care research

Healing Hearts, Changing Minds (HHCM) today announced the seven awardees of Walking Each Other Home: A Fund to Promote Psychedelic Compassion for End-of-Life Care, a $566,260 philanthropic initiative supporting innovation, compassion, and dignity for people at life's end.

27 Jan 2026

Charting brain cell epigenomics to reveal origins of psychiatric disorders

In a revealing Genomic Press Interview published today in Genomic Psychiatry, Dr. Maria Margarita Behrens recounts an extraordinary scientific journey that wound through four countries and multiple disciplines before arriving at fundamental questions about how the brain develops and what goes wrong in psychiatric disorders.

6 Jan 2026

Etomidate proves safer than ketamine for emergency intubations

Doctors treating seriously ill patients in an emergency setting may want to give the sedative etomidate, rather than ketamine, while placing a breathing tube, according to a randomized trial published Dec. 9 in the New England Journal of Medicine.

12 Dec 2025

Landmark RSI trial reshapes sedative selection for emergency airway management

9 Dec 2025

Laughing gas shows fast antidepressant effects in early clinical trials

A systematic review and meta-analysis in eBioMedicine shows that nitrous oxide can rapidly reduce depressive symptoms within hours, particularly at higher doses, but effects are short-lived after single treatments. Repeated dosing appears to extend and strengthen antidepressant benefits, although the current evidence is based on small, early-phase trials with limited long-term safety data.

8 Dec 2025

Brainwide circuitry mapping reveals how psilocybin drives therapeutic neural rewiring

An international collaboration led by Cornell University researchers used a combination of psilocybin and the rabies virus to map how – and where – the psychedelic compound rewires the connections in the brain.

5 Dec 2025

Hallucinogen-related hospital care linked to higher risk of future mania

People who have received emergency or hospital care in Canada due to hallucinogen use have a six-fold increased risk of receiving care for mania in the next three years, according to a study published December 2nd in the open-access journal PLOS Medicine by Daniel Myran from North York General Hospital in Canada and colleagues.

2 Dec 2025

Short-term nitrous oxide treatment could benefit patients with major depressive disorder

Patients with major depressive disorder, including those who have not responded to first-line antidepressants, may benefit from short-term nitrous oxide treatment, a major meta-analysis led by the University of Birmingham has found.

1 Dec 2025

The caffeine conundrum in rapid depression treatments

Perhaps the most intriguing implication of recent breakthrough research lies in an unexpected connection: the most rigorous mechanistic dissection of rapid antidepressant action identifies adenosine as the critical mediator, yet adenosine receptors are the primary target of caffeine, the world's most widely consumed psychoactive substance.

11 Nov 2025

Revolutionizing cataract surgery with office-based oral sedation

A new study on office-based cataract surgery is challenging traditional approaches to the procedure, demonstrating that patients can undergo successful surgery with minimal oral sedation instead of with intravenous (IV) sedation at hospitals or ambulatory surgery centers.

23 Oct 2025

Repeated ketamine infusions offer no extra benefit for people hospitalized with depression

Findings from a randomized and blinded clinical trial investigating repeated ketamine infusions for treating depression have revealed no extra benefit for ketamine when added onto standard care for people admitted to hospital for depression.

22 Oct 2025

Cops on ketamine? Largely unregulated mental health treatment faces hurdles

A few months ago, Waynesville Police Sgt. Paige Shell was about to give up hope of getting better. The daily drip of violence, death, and misery from almost 20 years in law enforcement had left a mark. Her sleep was poor, depression was a stubborn companion, and thoughts of suicide had taken root.

10 Oct 2025

Ketamine News and Research

Hearing loss and sex shape dual-task outcomes in older adults with mild cognitive impairment

NOX-1 identified as key molecular target to prolong ketamine's antidepressant effects

Study finds common brain mechanism behind different anesthesia drugs

PET imaging reveals molecular mechanism behind ketamine's antidepressant effects

Enhancing myelination may help sustain therapeutic effects of psychedelic-assisted PTSD treatment

Breathing patterns and brain activity become more independent during the deepest sleep

Study finds around six nightclub deaths occur annually in the UK

Psychedelic effects of ketamine do not predict sobriety

HHCM awards $566K to advance psychedelic end-of-life care research

Charting brain cell epigenomics to reveal origins of psychiatric disorders

Etomidate proves safer than ketamine for emergency intubations

Landmark RSI trial reshapes sedative selection for emergency airway management

Laughing gas shows fast antidepressant effects in early clinical trials

Brainwide circuitry mapping reveals how psilocybin drives therapeutic neural rewiring

Hallucinogen-related hospital care linked to higher risk of future mania

Short-term nitrous oxide treatment could benefit patients with major depressive disorder

The caffeine conundrum in rapid depression treatments

Revolutionizing cataract surgery with office-based oral sedation

Repeated ketamine infusions offer no extra benefit for people hospitalized with depression

Cops on ketamine? Largely unregulated mental health treatment faces hurdles

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