Nanobodies News and Research

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New molecule shows promise in protecting mice from influenza

Researchers at the University of Gothenburg, Sweden, in collaboration with colleagues in China, have discovered an antibody-like molecule that can protect mice from various influenza viruses.

9 Jan 2025

Researchers develop nanobody inhibitors to target Ebola virus

Ebola virus, one of the deadliest pathogens, has a fatality rate of about 50%, posing a serious threat to global health and safety.

7 Jan 2025

DNA-based nanorobotic hand could block viruses and enable rapid diagnostics

A tiny, four-fingered "hand" folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, University of Illinois Urbana-Champaign researchers report.

27 Nov 2024

Futuristic AI-powered virtual lab designs potent SARS-CoV-2 nanobodies

AI-human collaboration in a "Virtual Lab" successfully designs and experimentally validates nanobodies with enhanced binding to SARS-CoV-2 variants, offering a novel approach to interdisciplinary research.

14 Nov 2024

New antibody platform targets evolving viruses

Scientists at the Icahn School of Medicine at Mount Sinai, in collaboration with colleagues in the field, have developed an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2: their ability to mutate and evade existing vaccines and therapies.

23 Oct 2024

Tiny molecule offers hope in reducing opioid side effects

Opioid drugs are highly effective at relieving pain but come with severe drawbacks. Their side effects range from dizziness to potentially fatal respiratory depression.

9 Oct 2024

Scientists unravel the process of pore formation in cells

The formation of pores by a particular protein, gasdermin D, plays a key role in inflammatory reactions. During its activation, an inhibitory part is split off. More than 30 of the remaining protein fragments then combine to form large pores in the cell membrane, which allow the release of inflammatory messengers.

26 Sep 2024

Sino Biological and BioGeometry Deepen Strategic Cooperation to Empower Protein R&D with Generative AI

Sino Biological, a leading recombinant protein production company, is pleased to announce an expansion of its strategic partnership with BioGeometry, a pioneer in digital biology.

From Sino Biological Inc. 12 Sep 2024

New Mpox strain sparks global health alert

On Wednesday, August 14th, 2024, in response to the active circulation of clade 1 monkeypox virus (MPXV) in Central Africa and the recent expansion of a subtype (1b) thought to be more lethal and transmissible in East Africa, the World Health Organization (WHO) declared a public health emergency of international concern (PHEIC), paving the way for enhanced coordination between regional health systems and the active engagement of stakeholders to tackle this global outbreak. The following day, Thursday August 15, Sweden reported the first positive case of clade 1b mpox on European soil. This led the French government to place the French health system on maximum alert on Friday, August 16, and the French authorities have now begun to re-evaluate the health recommendations established in 2022 during the previous mpox outbreak in preparation for the probable emergence of cases in the country.

23 Aug 2024

Llama-derived molecules target hidden strains of HIV

A research team at Georgia State University has developed tiny, potent molecules that are capable of targeting hidden strains of HIV. The source? Antibody genes from llama DNA.

17 Jul 2024

Nanobody technology revolutionizes food allergy detection methods

Recent advancements show nanobodies from camelid antibodies excel in food allergen detection with superior stability, specificity, and cost-effectiveness. This innovative approach aims to improve accuracy and efficiency, crucial for preventing severe allergic reactions. The study highlights nanobodies' potential in reliable immunoassays, addressing rising food allergies and enhancing safety measures. Food allergies pose significant health risks, affecting millions worldwide, with the prevalence rising over the past decades.

18 Jun 2024

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain.

3 Apr 2024

Anti-CTLA-4 nanobodies offer promising strategy to prevent colitis in cancer immunotherapy

Microbiota-reactive T cells trigger colitis in mice harboring the microbiota of wild-caught mice following CTLA-4 blockade, according to a new study that reveals a major mechanism by which anti-CTLA-4 antibodies induce inflammatory toxicities during antitumor immune checkpoint inhibitor therapies.

4 Jan 2024

Scientists unveil 3D structure of key immune system component

An international team of researchers from LMU and the Helmholtz Centre for Infection Research has visualized the structure of the so-called ASC speck.

8 Dec 2023

VUB researchers develop a nanobody-based technology to prevent liver inflammation

Mathieu Vinken, a professor in the In Vitro Toxicology and Dermato-cosmetology (IVTD) lab at the Vrije Universiteit Brussel, and doctoral student Raf Van Campenhout have developed a technique based on nanobody technology to prevent liver inflammation.

8 Dec 2023

Research uncovers stealthy strategy of SARS-CoV-2 infection

Researchers have discovered a novel mechanism whereby the SARS-CoV-2 virus, which causes COVID-19, can vary its mode of infection in human cells. Published in the journal eLife, a team from the University of Minnesota and the Midwest Antiviral Drug Discovery (AViDD) Center found the virus can alternate between being highly infectious and avoiding detection by the immune system.

5 Dec 2023

Bonn immunologist receives €2 million grant to harness the power of nanobodies for inflammation control

Bonn immunologist Prof. Florian I. Schmidt, who conducts research at the Institute of Innate Immunity at the University Hospital Bonn (UKB), has been awarded a Consolidator Grant from the European Research Council to fund his research project DEFLAMMATION with two million Euro.

23 Nov 2023