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Experimental vaccine protects against fentanyl and related opioids

Fentanyl and related variants of the synthetic opioid kill more Americans each year than car accidents and gun violence combined. In too-high doses, the drugs hijack brain chemistry and shut down the signals that control breathing.

11 Jun 2026

Researchers identify hidden self-harm histories using machine learning

Important mental health history is often present in medical records but hard to find, especially when it is missing from the diagnosis codes that clinicians, researchers and health systems use to search and count conditions.

5 Jun 2026

Falling fentanyl deaths drive historic drop in American drug overdoses

Researchers from the University of California San Diego have found that U.S. overdose death rates declined dramatically between 2023 and 2024, marking the first recorded drop in all four waves of the nation's overdose crisis.

2 Jun 2026

Innovative platform bridges the gap between OUD treatment and HIV prevention

People with opioid use disorder (OUD) are at increased risk of contracting human immunodeficiency virus (HIV). While there are effective interventions that can substantially reduce HIV incidence and opioid overdose, like pre-exposure prophylaxis (PrEP) and medications for opioid use disorder (MOUD), many patients still face barriers to accessing and staying engaged in care.

22 May 2026

Real-time memory tests identify alcohol-induced blackouts as they happen

It's not surprising if someone experiences memory loss, or a 'blackout,' while drinking alcohol. While common, blackouts are considered a public health concern linked to injury, arrest, assault and overdose.

20 May 2026

ExiVex reports in-human pharmacokinetic data showing EMRX-101 intranasal naloxone approaches IV-like peak plasma concentrations with substantially faster Tmax than currently approved comparator

ExiVex Biopharma (formerly EmerRx Biopharma), a clinical-stage pharmaceutical company developing a proprietary dual-chamber intranasal drug delivery platform, today announced in-human pharmacokinetic (PK) data for its lead candidate EMRX-101, an intranasal naloxone product targeting opioid-induced respiratory depression.

From Hanson Wade Group - 4th Nasal Formulation & Delivery Summit 15 May 2026

Opioid overdose survivors face elevated mortality risk within one year

After an emergency department visit for an opioid overdose, 9 per cent of individuals died and 21 per cent experienced a repeat opioid overdose in the following year, according to a new study from ICES and the Centre for Addiction and Mental Health (CAMH).

7 May 2026

Study uncovers overlooked crisis of paternal deaths after childbirth

It took the better part of a century for maternal mortality to be recognized, forgotten and finally recognized again as an urgent public health crisis in the United States.

4 May 2026

NIH awards $3.9 million grant to develop a non-opioid pain treatment

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health (NIH), has awarded a $3.9 million grant to a multi-institutional team led by scientists at Sanford Burnham Prebys Medical Discovery Institute to develop a non-opioid pain therapeutic and advance it into a Phase 1 clinical trial.

4 May 2026

TikTok chatter could help predict where the opioid crisis is heading next

A large-scale analysis of 569,581 TikTok comments found that opioid-related discussions may help track and forecast synthetic opioid overdose mortality in the US. Recovery, harm reduction, drug use, drug sourcing, and loss-related conversations provided near-real-time signals that improved 6-month forecasting accuracy.

28 Apr 2026

New clinical guidelines significantly reduce opioid prescriptions after ear surgery

A new retrospective study published in OTO Open, the open-access journal of the American Academy of Otolaryngology–Head and Neck Surgery Foundation (AAO-HNSF), demonstrates that the Clinical Practice Guideline (CPG) Opioid Prescribing for Analgesia After Common Otolaryngology Operations has had a measurable and sustained impact on prescribing practices following parotidectomy, which a surgical procedure to remove the parotid gland.

28 Apr 2026

U.S. dentists still prescribe opioids at higher rates globally

People getting their teeth pulled or drilled by dentists in the United States are still much more likely to get powerful opioid medications than dental patients in other developed countries or even the U.S. territory of Puerto Rico, a new study finds.

23 Apr 2026

Study highlights gaps in opioid use disorder care during pregnancy

Opioid use disorder during pregnancy remains a critical yet under-addressed public health issue in the U.S., according to a new study at Columbia University Mailman School of Public Health.

23 Apr 2026

Standard naloxone doses may not reverse newer synthetic opioid overdoses

A new study exposes challenges in reversing opioid overdoses with naloxone when potent synthetic drugs like fentanyl and sufentanil are involved, according to a study in the May 2026 issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

13 Apr 2026

Apparent drug overdose spike in 2025 driven by flawed modeling

Last June, several mainstream media outlets reported a surge in U.S. drug overdose deaths in early 2025 that was based on data from the U.S. Centers for Disease Control and Prevention (CDC).

8 Apr 2026

Expanded Medicaid improved access to buprenorphine for opioid use disorder

Medicaid insurance expansions between 2017 and 2023 sharply increased access to medication treatment for opioid use disorder in a period when fatal overdoses continued to climb, according to Rutgers Health researchers.

6 Apr 2026

Many US jails lack nearby access to opioid treatment programs, study shows

A new study led by researchers at Brown University School of Public Health found that more than half of U.S. jails are located at least a 30-minute drive from the nearest opioid treatment program - a distance that may make it harder for incarcerated people to receive methadone, a key medication for opioid addiction.

2 Apr 2026