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Hypoxia-gated AAV enables targeted treatment for advanced NSCLC

Adeno‑associated virus (AAV) vectors offer safety and durable expression but lack tumor specificity. This hypothesis proposes an NSCLC‑directed, hypoxia‑responsive AAV platform that integrates MGS4 peptide‑guided capsid targeting with dual hypoxia‑responsive element (HRE)‑gated promoters driving Q‑CXCL9‑Fc (chemokine) and miR‑30‑based shRNA against mesothelin (MSLN).

1 Jun 2026

The growing role of NIR-II imaging in preclinical research

NIR-II imaging has many advantages for preclinincal research as it supports deeper visualization with lower scattering and autofluorescence.

From Scintica Instrumentation Inc. 29 May 2026

Second-career nursing candidates help solve national staffing shortages

While the usual conversation about our national nursing shortage focuses on how to recruit young people, there is another potential pipeline: people in their 40s and 50s—often pursuing a second career—who are also, in many ways, exactly the nurses that NYU Langone Health needs.

22 May 2026

GADD45B promotes apoptosis in intestinal injury through DNA demethylation

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

5 May 2026

Epigenome proteins shape dynamic gene expression beyond simple on-off

A new study finds the proteins responsible for controlling which genes are expressed in a genome do more than simply turn a gene on or off.

21 Apr 2026

Microbial "signatures" within the oral cavity and gut may aid in gastric cancer detection

A recent study published in Cell Reports Medicine has identified distinct microbial "signatures" within the oral cavity and gut that serve as robust biomarkers for the early detection of gastric cancer (GC).

20 Apr 2026

Study maps DNA methylation changes driving MDS stem cell dysfunction

Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led by Prof. Cao at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, along with Dr. Liangding Hu at the Fifth Medical Center of Chinese PLA General Hospital, and Professors Qian Zhang and Yanmei Han at the National Key Laboratory of Immunity and Inflammation, Naval Medical University, has generated the first base-resolution DNA methylome of human MDS HSCs.

9 Apr 2026

p38 MAPK drives epigenetic activation of fibrotic genes in lung fibroblasts

A new research paper was published in Volume 18 of Aging-US on March 3, 2026, titled "P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung fibroblasts."

10 Mar 2026

STING agonists exert potent antitumor effects against nervous system tumors

The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses.

9 Mar 2026

How somatic mutations shape disease and reveal new drug targets

Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular resilience. The study proposes somatic genomics as a powerful strategy to uncover disease mechanisms and identify new therapeutic targets across multiple conditions.

8 Mar 2026

BCAT2 enzyme identified as a target for diabetic foot recovery

Diabetic macrovascular complications are the main cause of death and disability in diabetes patients, of which vascular calcification is one of the key pathological mechanisms. Calcification in atherosclerotic plaque can cause stiffness and decreased compliance of the vascular wall, and induce atherosclerotic plaque rupture, which increases the risk of acute cardiovascular events.

6 Mar 2026

Study sheds light on potential therapeutic strategies for post-traumatic osteoarthritis

Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury.

4 Mar 2026

Study sheds light on behavior of yeast cells in the gut

A new study sheds light on the behavior of yeast cells in the gut, paving the way for new lines of yeast that more efficiently produce therapeutic drugs tailored to address specific diseases.

24 Feb 2026

SynGenSys introduces Liver.SET synthetic promoter library for liver-specific gene expression for in vivo gene therapies

SynGenSys, a biotechnology company designing synthetic gene promoter systems to address critical bottlenecks in biopharma manufacturing and enhance cell and gene therapy development, today announced the launch of its Liver.SET™ library of liver-specific synthetic promoters.

5 Feb 2026

How DNA and life experiences leave distinct marks on the human immune system

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and environmental exposures shape the human immune system through distinct DNA methylation mechanisms. Genetic effects concentrate within gene bodies of memory cells, while environmental exposures primarily remodel regulatory regions in naive immune cells.

28 Jan 2026

Cigarette compound exposure drives sorafenib resistance in hepatocellular carcinoma

A research team led by Professor Yuan Li at Nanjing Medical University published a research paper entitled "A Cigarette Compound-Induced Tumor Microenvironment Promotes Sorafenib Resistance in Hepatocellular Carcinoma via the 14-3-3η-Modified Tumor-Associated Proteome" in the Chinese Medical Journal.

23 Jan 2026

Far-red light suppresses biofilm formation and virulence in pathogenic bacteria

Light is a universal stimulus that influences all living things. Cycles of light and dark help set the biological clocks for organisms ranging from single-celled bacteria to human beings.

20 Jan 2026

COVID-19 severity is linked to changes in mitochondrial DNA methylation

This study examined mitochondrial and nuclear-encoded mitochondrial DNA methylation in Indian patients with severe COVID-19 and found region-specific differential methylation linked to disease severity. Pathway analyses and protein assays implicated disrupted mitochondrial metabolism and dynamics, suggesting a role for mitochondrial epigenetic regulation in COVID-19 pathophysiology.

20 Jan 2026

Blocking platelet-activating factor reduces liver damage in cirrhosis

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis.

19 Dec 2025

Disrupted genome architecture drives lymphoma development

Cancer isn't just about broken genes-it's about broken architecture. Imagine a city where roads suddenly vanish, cutting off neighborhoods from essential services.

10 Dec 2025