Protein Stability News and Research

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AI unveils secrets of protein stability

Researchers at the Center for Algorithmic and Robotized Synthesis within the Institute for Basic Science have taken a significant step forward in understanding the stability of proteins by leveraging the power of AI. The research team used AlphaFold2 to explore how mutations affect protein stability - a crucial factor in ensuring proteins function correctly and do not cause diseases like Alzheimer's.

29 Aug 2024

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

The study investigates the role of the deubiquitinase OTUB1 in vascular smooth muscle cells (VSMCs) within the context of atherosclerosis, a disease characterized by lipid accumulation and plaque formation in arteries.

27 Aug 2024

Maternal gut bacteria linked to changes in fetal brain metabolism

The impact of Bifidobacterium breve's presence in the maternal gut during pregnancy on fetal brain metabolism.

23 Aug 2024

Research reveals immune suppression link between cancer and pregnancy

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.

8 Jul 2024

Simple peptide modification could unlock a whole class of targets for drug discovery

A relatively simple peptide modification could unlock a whole class of targets for drug discovery, new research shows.

7 Jun 2024

Magnesium's pivotal role in slowing aging's impact

Review highlights magnesium's critical role in mitigating aging hallmarks, including telomere attrition, genomic instability, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion, suggesting that maintaining adequate magnesium levels could support healthy aging.

13 Feb 2024

Catenane magic: Boosting protein stability and resilience with interlocking rings

This study is led by Prof. Wen-Bin Zhang (College of Chemistry and Molecular Engineering, Peking University & Beijing Academy of Artificial Intelligence) and Dr. Jing Fang (College of Chemistry and Molecular Engineering, Peking University).

29 Dec 2023

Genetic mutation in OXR1 gene linked to brain development issues

Study investigates the effects of a loss-of-function mutation in the OXR1 gene on neurodevelopment and cellular functions in the human brain. The research shows that OXR1 deficiency impairs neural differentiation, increases sensitivity to oxidative stress, and alters histone methylation, impacting brain development and potentially contributing to neurological disorders.

27 Nov 2023

Same cellular mechanism implicated in cystic fibrosis and rare disease cystinosis

University of Michigan researchers have discovered that the same cellular mechanism involved in a form of cystic fibrosis is also implicated in a form of a rare disease called cystinosis.

28 Aug 2023

Japanese squirrels may be a model for human amyloidosis

A research group led by Dr. Tomoaki Murakami from the Tokyo University of Agriculture and Technology has revealed that fibrinogen Aα-chain amyloidosis, a previously unreported disease in animals other than humans, is highly prevalent in Japanese squirrels (Sciurus lis).

18 Aug 2023

Scientists discover potential biomarkers linked to metastatic prostate cancer in Black men

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have identified a cell metabolism process found in men with diabetes and metastatic prostate cancer that could one day lead to improved testing and treatments for Black men with these diseases.

15 Aug 2023

Difficult transmembrane protein targets for therapeutic antibodies

In this interview, News-Medical talks to Sylvia Xie, product scientist at Sino Biological, about the ongoing emergence of transmembrane proteins as targets for therapeutic antibodies.

From Sino Biological Inc. 12 Jul 2023

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Finding, cultivating, and bioengineering organisms that can digest plastic not only aids in the removal of pollution, but is now also big business.

13 May 2023

Deep mutational scanning for SARS-CoV-2 Omicron BA.1 and BA.2 subvariants

Researchers performed deep mutational scanning for the SARS-CoV-2 Omicron variant of concern sub-VOC BA.1 and BA.2 receptor-binding domains.

22 Sep 2022

Virtual screening and molecular dynamics explore potential repurposed drugs against monkeypox virus

A recent study investigated ‘targets’ in the poxvirus and identified the protein residues active in MPV, following which eight potential anti-viral drugs were proposed.

25 Aug 2022

The role of FTIR in protein analysis and biomedical applications

Professor Dr. Werner Mantele is the Professor of Biophysics at Goethe University and Frankfurt University. With over 30 years of experience with spectroscopy, Dr. Mantele is an internationally-recognized expert in the analysis and detection of molecules.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 18 Jul 2022

Protein Stability News and Research

AI unveils secrets of protein stability

Exploring OTUB1's influence on protein stability and atherosclerosis pathophysiology

Maternal gut bacteria linked to changes in fetal brain metabolism

Research reveals immune suppression link between cancer and pregnancy

Simple peptide modification could unlock a whole class of targets for drug discovery

Magnesium's pivotal role in slowing aging's impact

Catenane magic: Boosting protein stability and resilience with interlocking rings

Genetic mutation in OXR1 gene linked to brain development issues

Same cellular mechanism implicated in cystic fibrosis and rare disease cystinosis

Japanese squirrels may be a model for human amyloidosis

Scientists discover potential biomarkers linked to metastatic prostate cancer in Black men

Difficult transmembrane protein targets for therapeutic antibodies

Swiss researchers identify plastic-degrading microbial strains in the Alps and Arctic region

Deep mutational scanning for SARS-CoV-2 Omicron BA.1 and BA.2 subvariants

Virtual screening and molecular dynamics explore potential repurposed drugs against monkeypox virus

The role of FTIR in protein analysis and biomedical applications

Generation of live attenuated influenza A virus vaccine using PROTAC technology

Study evaluates mutation-induced SARS-CoV-2 spike protein fold stability

The impact of natural selection on sequence diversity in SARS-CoV-2

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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