Temozolomide News and Research

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Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Polyphenols and exercise show promise in fighting gliomas

A new review in Food Science & Nutrition highlights how combining dietary polyphenols with structured exercise can enhance brain function, regulate epigenetics, and support glioma management. The authors outline mechanisms, patient-centered strategies, and research gaps for turning this synergy into clinical practice.

12 Aug 2025

Niigata University team reports novel treatment for IDH2-mutant brainstem glioma

A group led by the Department of Neurosurgery at the Brain Research Institute, Niigata University, has successfully treated a patient with a brainstem glioma harboring a rare IDH2 mutation.

17 Jul 2025

Glioblastoma patients live longer with triple treatment strategy

A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments.

9 Jun 2025

New peptide therapy shows promise against glioblastoma recurrence

A lab-designed molecule developed and extensively studied by scientists with Virginia Tech's Fralin Biomedical Research Institute at VTC could represent a breakthrough in slowing tumor recurrence in glioblastoma, an aggressive and deadly form of brain cancer.

29 May 2025

Triple therapy reduces tumor burden and improves survival in glioblastoma models

A new research paper was published in Oncotarget, Volume 16, on March 27, 2025, titled "Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT."

4 Apr 2025

Innovative brain tumor model offers hope for personalized cancer treatments

Scientists from the German Cancer Research Center (DKFZ) and ShanghaiTech University have developed an innovative method for growing brain tumors of individual patients in the laboratory that mimic the original structure and the molecular property of the parental tumor as closely as possible.

11 Feb 2025

New insights into glioblastoma resistance to temozolomide

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used as the front-line medicine in its treatment.

19 Dec 2024

Temozolomide and radiation combination improves survival in low-grade glioma patients

Both radiation and temozolomide, a generic chemotherapy treatment in pill form, have meaningful single-modality anti-tumor activity against slow-growing, low-grade gliomas.

25 Nov 2024

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option in combination with temozolomide.

21 Nov 2024

Groundbreaking study challenges treatment protocols for glioblastoma in older adults

A groundbreaking study led by Dr Monika E. Hegi, MD, PhD and European Organisation for Research and Treatment of Cancer (EORTC) headquarters team (Felix Oppong Msc, Dr Thierry Gorlia, PhD) reveals that older adults glioblastoma patients with truly unmethylated MGMT promoter do not benefit from temozolomide (TMZ) treatment, challenging current treatment protocols and paving the way for more personalised therapies.

9 Oct 2024

Discovery of cyclotide from violets enhances glioblastoma chemotherapy

Glioblastoma is one of the most serious brain diseases known. More than 45% of brain cancers are gliomas.

30 Sep 2024

Neuroactive drugs show promising anti-glioblastoma effects in preclinical trials

Study explores the potential to repurpose neuroactive drugs, originally approved for neurological disorders, for the treatment of glioblastoma. Vortioxetine, an antidepressant, showed promising anti-glioblastoma activity, significantly reducing tumor size in preclinical trials.

24 Sep 2024

Temozolomide News and Research

Electrophysiology-based strategies enhance cancer immunotherapy

Polyphenols and exercise show promise in fighting gliomas

Niigata University team reports novel treatment for IDH2-mutant brainstem glioma

Glioblastoma patients live longer with triple treatment strategy

New peptide therapy shows promise against glioblastoma recurrence

Triple therapy reduces tumor burden and improves survival in glioblastoma models

Innovative brain tumor model offers hope for personalized cancer treatments

New insights into glioblastoma resistance to temozolomide

Temozolomide and radiation combination improves survival in low-grade glioma patients

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Groundbreaking study challenges treatment protocols for glioblastoma in older adults

Discovery of cyclotide from violets enhances glioblastoma chemotherapy

Neuroactive drugs show promising anti-glioblastoma effects in preclinical trials

Targeted alpha therapy offers hope for glioblastoma patients

Combining anlotinib with STUPP regimen improves survival in glioblastoma patients

Study identifies PI3K-beta as key target in overcoming chemotherapy resistance in glioblastoma

UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

Novel CAR-T therapy shows promising results in glioblastoma patients

Glioblastoma tumor cells mimic neurons to evade treatment

Children with neuroblastomas may benefit from new drug cocktail

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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