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A striking immune cell pattern emerges around a person’s 100th birthday

Single-cell immune profiling found that CD4 cytotoxic T lymphocytes become more abundant around age 100, showing stepwise differentiation and substantial clonal expansion. Ex vivo experiments also revealed cytokine plasticity within individual clones, supporting the hypothesis that these cells adapt to persistent antigens during healthy aging, although their direct role in longevity remains unproven.

23 Aug 2026

New battery-free pacemaker harvests power from every heartbeat

A team of University of Wisconsin–Madison researchers has developed an implantable, battery-free pacemaker that's charged by a patient's heartbeat.

19 Aug 2026

New optical control platform blocks and restores neural signaling

DGIST (President Kunwoo Lee) announced that a research team led by Professor Ji Won Um of the Center for Synapse Diversity and Specificity, Department of Brain Sciences, in collaboration with a research team led by Professor Alice Ting at Stanford University, has developed LATeNT, a novel optical control platform that uses light to block signal transmission between neurons and subsequently restore normal signaling.

19 Aug 2026

Polydatin reduces ulcerative colitis by regulating intestinal immune cells

Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which recurrent intestinal inflammation can be difficult to control over the long term.

17 Aug 2026

A Mediterranean ingredient gave gluten-free pasta an unexpected upgrade

Researchers developed carob-enriched gluten-free tagliatelle that increased dietary fiber and antioxidant activity while reducing starch digestibility and improving pasta structure. A 20% carob substitution provided the best overall balance of functional properties, texture, and consumer acceptance, although clinical health benefits remain to be established.

17 Aug 2026

Youth-associated protein reverses age-related microglial changes in mice

Researchers at The Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain's resident immune cells.

14 Aug 2026

Coral-inspired scaffold enhances bone repair by reprogramming immune cells

SONFH is one of the leading causes of non-traumatic osteonecrosis. Reported in up to 9%–40% of patients receiving prolonged or high-dose glucocorticoid therapy, the condition progressively weakens the femoral head and can eventually lead to joint collapse, making effective bone repair a major clinical challenge.

13 Aug 2026

Mitochondrial rewiring may explain why orthoflaviviruses harm humans but persist in mosquitoes

Orthoflaviviruses reshape mitochondrial structure, metabolism, redox signaling, and quality control differently across human and mosquito models, helping explain their contrasting infection outcomes. The review highlights mitochondrial pathways that may support acute cellular damage in vertebrates but persistent, non-lethal infection in mosquitoes, pointing to potential antiviral targets.

12 Aug 2026

Mitochondrial gene RTN4IP1 drives triple-negative breast cancer metastasis

Triple-negative breast cancer accounts for approximately 15% of all breast cancer cases. It is characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, rendering it insensitive to conventional endocrine and targeted therapies.

12 Aug 2026

Cannabis compounds may weaken glioblastoma response to chemotherapy and radiation

Several cannabinoids reduced chemotherapy- and radiation-induced apoptosis in glioblastoma cell models, with effects linked to reduced apoptotic priming, increased pro-survival signaling, and G1 cell-cycle arrest. The findings raise concern that cannabinoid exposure could interfere with some cancer treatments, although the results are limited to laboratory models and require in vivo and clinical validation.

12 Aug 2026

New imaging model can detect early brain changes in Huntington's disease

Researchers have shown that an imaging model can detect microstructural abnormalities in the brain associated with Huntington's disease, potentially offering a new method for monitoring disease progression and evaluating new treatments.

11 Aug 2026

Nocturnal micro-awakenings linked to genetic risk of Alzheimer's disease

What if certain signs of the disease were to manifest themselves subtly during sleep, long before the first memory problems appear? This is the line of inquiry being explored by a team of researchers at ULiège, with the support of the Stop Alzheimer's Foundation.

11 Aug 2026

Voltammetry and machine learning for real-time neurotransmitter detection

Anne Andrews (UCLA) explains how voltammetry and machine learning can track multiple neurotransmitters in real time, even with overlapping signals.

From Pittcon 10 Aug 2026

Genetic analysis of 1 million people points to FNIP1 as a promising metabolic target

Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome.

7 Aug 2026