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Exercise-induced exerkines: Secret weapon in disease prevention and therapy

A recent review in Signal Transduction and Targeted Therapy highlights the role of exercise-induced molecules, exerkines, in disease prevention and treatment, emphasizing their molecular mechanisms and therapeutic potential.

29 May 2024

Researchers develop novel method to 'grow your own' donor skin

Skin grafting is an essential procedure used to treat severe skin wounds. In the case of extensive wounds, however, it can be challenging to harvest enough donor skin, and generating artificial skin substitutes that include hair follicles and sweat glands and can engraft on deep wounds has not been successful.

29 May 2024

Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

The antiviral efficacy and therapeutic potential of harmol in treating herpes simplex virus type 1 (HSV-1) induced keratitis

29 May 2024

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Researchers discovered that Plexin-B1 plays a crucial role in regulating peri-plaque glial nets in Alzheimer’s disease, potentially opening new avenues for treatment by targeting this protein.

29 May 2024

Targeting CD47 to improve osimertinib efficacy in EGFR mutant NSCLC

NSCLC is the leading cause of cancer deaths globally, with EGFR mutations being a common feature in these cancers.

28 May 2024

Psilocybin use initiates hyperconnectivity in the brain linked to ego-modifying effects

A new study shows that the use of psilocybin, a compound found in the widely known "magic mushrooms," initiates a pattern of hyperconnectivity in the brain linked to the ego-modifying effects and feelings of oceanic boundlessness.

23 May 2024

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development.

23 May 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

Exercise enhances efficacy of antibody therapy in leukemia patients

Bouts of moderate-to-vigorous intensity exercise could improve the efficacy of antibody therapies used to treat chronic lymphocytic leukemia, new research has shown.

21 May 2024

New CRISPR screen method reveals cellular drivers of neurological disorders

The brain is often referred to as a "black box"-;one that's difficult to peer inside and determine what's happening at any given moment.

20 May 2024

Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibition

Bimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models.

20 May 2024

Non-viral gene therapy offers hope for chronic low back pain sufferers

A novel non-viral gene therapy for discogenic back pain (DBP).

20 May 2024

Study shows how working memory improves through practice

"Practice makes perfect" is no mere cliché, according to a new study from researchers at The Rockefeller University and UCLA. Instead, it's the recipe for mastering a task, because repeating an activity over and over solidifies neural pathways in your brain.

17 May 2024

Novel gene-delivery vehicle shows promise for treating brain disorders

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human protein to efficiently cross the blood-brain barrier and deliver a disease-relevant gene to the brain in mice expressing the human protein.

16 May 2024

Mechanistic insights into the role of huc-mscs in treating acute liver failure

Acute liver failure (ALF) is a life-threatening clinical problem with limited treatment options. Administration of human umbilical cord mesenchymal stem cells (hUC-MSCs) may be a promising approach for ALF.

16 May 2024

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

The protein galectin-1 (Gal-1) has been identified as a new PET imaging biomarker for immune checkpoint blockade (ICB) therapy, allowing physicians to predict the tumor responses before beginning treatment.

15 May 2024

Sleep and anesthesia hinder brain toxin clearance, study reveals

Researchers found that brain clearance is reduced during both sleep and anesthesia, contradicting the belief that these states enhance toxin removal.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Using human cells in laboratory rats, Michigan Medicine researchers have developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition, a study suggests.

14 May 2024

Machine learning unveils hidden gender differences in brain structure

Artificial intelligence (AI) computer programs that process MRI results show differences in how the brains of men and women are organized at a cellular level, a new study shows.

14 May 2024

in vivo News and Research

Exercise-induced exerkines: Secret weapon in disease prevention and therapy

Researchers develop novel method to 'grow your own' donor skin

Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Targeting CD47 to improve osimertinib efficacy in EGFR mutant NSCLC

Psilocybin use initiates hyperconnectivity in the brain linked to ego-modifying effects

In-vivo imaging to quantify collagen morphology in preclinical melanoma models during immunotherapy

Tailoring polymeric micelles for improved olaparib solubility and drug release

Exercise enhances efficacy of antibody therapy in leukemia patients

New CRISPR screen method reveals cellular drivers of neurological disorders

Treating obesity using glucagon-like peptide-1-directed N-methyl-D-aspartate receptor inhibition

Non-viral gene therapy offers hope for chronic low back pain sufferers

Study shows how working memory improves through practice

Novel gene-delivery vehicle shows promise for treating brain disorders

Mechanistic insights into the role of huc-mscs in treating acute liver failure

New PET imaging biomarker Gal-1 predicts tumor responses to immunotherapy

Sleep and anesthesia hinder brain toxin clearance, study reveals

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

Human cell-based model of thoracic aortic aneurysm offers new opportunities for drug development

Machine learning unveils hidden gender differences in brain structure

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From Discovery Biology to ELRIG Chair

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