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Orphan, CU to develop enzyme replacement therapy for CBS-deficient homocystinuria

The University of Colorado (CU) has signed exclusive, worldwide licensing and collaboration agreements with rare-disease research-and-development firm Orphan Technologies Ltd to develop an enzyme replacement therapy for Cystathionine Beta-Synthase (CBS) -deficient homocystinuria, a rare, inherited metabolic disease that is often fatal at a young age.

25 Feb 2013

Folic acid supplements reduce risk of giving birth to children with autism

Women who took folic acid supplements in early pregnancy almost halved the risk of having a child with autism. Beginning to take folic acid supplements later in pregnancy did not reduce the risk.

13 Feb 2013

Eight ways to say ‘I love you’ from Loyola dietitian

If you want to keep your true love's heart beating strong, Susan Ofria, clinical nutrition manager at Gottlieb Memorial Hospital, said the real food of love is dark chocolate and red wine. In moderation, red wine and dark chocolate are good health choices not just on Valentine's Day, but for any occasion.

12 Feb 2013

Valproate, pregnancy and IQ: an interview with Professor Kimford Meador

Valproate (sodium salt of valproic acid) is an anticonvulsant used in the treatment of epilepsy, migraine and bipolar disorder as well as some other off label psychiatric indications.

11 Feb 2013

Merck full-year 2012 worldwide sales decrease 2% to $47.3 billion

Merck, known as MSD outside the United States and Canada, today announced financial results for the fourth quarter and full year of 2012.

1 Feb 2013

Cancer risk independent of folic acid supplementation

Folic acid supplementation does not increase or decrease the risk for cancer, suggests research published in The Lancet.

28 Jan 2013

Lasting impact of fetal valproate exposure

Fetal exposure to the antiepileptic drug valproate has a dose-dependent negative impact on children’s IQ at age 6 years, shows a study in The Lancet Neurology.

25 Jan 2013

Short-term use of folic acid supplements unlikely to increase cancer risk

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25 Jan 2013

Article analyzes role of nutrition in mood swings

In this study, preliminary data yields conflicting but mainly positive evidence for the use of n-3 fatty acids and chromium in the treatment of bipolar depression. Limited evidence found that inositol may be helpful for bipolar depression, but larger sample sizes are needed. Preliminary randomized, controlled trials suggest that choline, magnesium, folate and tryptophan may be beneficial for reducing symptoms of mania.

23 Jan 2013

Study finds relationships between body size and epigenetic changes

New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by ageing but are also affected by what we eat.

6 Dec 2012

Low folate and vitamin B12 intake increase risk of melancholic depressive symptoms

A low intake of folate and vitamin B12 increases the risk of melancholic depressive symptoms, according to a study among nearly 3,000 middle-aged and elderly Finnish subjects. On the other hand, non-melancholic depressive symptoms are associated with an increased risk for the metabolic syndrome.

27 Nov 2012

Mass spectrometry can help visualize how drugs work inside living cells to kill infectious microbes

Weill Cornell Medical College researchers report that mass spectrometry, a tool currently used to detect and measure proteins and lipids, can also now allow biologists to "see" for the first time exactly how drugs work inside living cells to kill infectious microbes.

3 Nov 2012

Homocysteine not linked to cognition in FEP

Patients experiencing a first episode of psychosis have significantly higher homocysteine levels than mentally healthy individuals, researchers report.

26 Oct 2012

AAPS recognizes top scientists in pharmaceutical sciences

During the Opening Session of the 2012 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, AAPS President David Y. Mitchell, Ph.D., presented the following ground-breaking researchers with awards commemorating their contributions to the pharmaceutical sciences:

15 Oct 2012

No link between folic acid, vitamin B6 and 12 and increased risk of colorectal adenoma

Combined folic acid, vitamin B6 and vitamin B12 supplements had no statistically significant effect on the risk of colorectal adenoma among women who were at high risk for cardiovascular disease, according to a study published October 12 in the Journal of the National Cancer Institute.

15 Oct 2012

Rising rates of obesity lead to increases in bariatric surgery

With rising rates of morbid obesity, the number of bariatric surgery procedures is likely to increase as well, reports a paper in the October issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS).

3 Oct 2012

Maternal choline intake could essentially change fetal genetic expression into adulthood

Just as women are advised to get plenty of folic acid around the time of conception and throughout early pregnancy, new research suggests another very similar nutrient may one day deserve a spot on the obstetrician's list of recommendations.

24 Sep 2012

Light alcohol consumption may increase risk of certain cancers

The majority of observational studies have shown that alcohol intake, especially heavy drinking, increases a number of upper-aero-digestive tract (UADT) and other cancers, and even moderate drinking is associated with a slight increase in the risk of breast cancer.

19 Sep 2012

Nutrient intake linked to depression risk

Increased intakes of zinc, magnesium, and folate are associated with a reduced risk for depression in women, results from an Australian study show.

18 Sep 2012

Eat your greens for healthy sperm genes

Men who consume a high amount of certain nutrients may produce healthier sperm than men who do not, an effect that appears to be more pronounced in older men, report US researchers.

3 Sep 2012