Platelets News and Research

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COVID-19 patient with repeatedly undetectable SARS-CoV-2 antibodies

A recent case study published in the Journal of Applied Laboratory Medicine in August 2020 illustrates this with its finding of persistent seronegativity in a patient confirmed to be SARS-CoV-2 positive.

10 Aug 2020

Immunothrombotic dysregulation is key marker of disease severity in COVID-19

In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

7 Aug 2020

Researcher is exploring safer and more effective treatment for leukemia

A potentially safer, more effective chemotherapy treatment for patients with blood-related cancers, such as leukemia, who need a particular bone marrow transplant procedure is under study at the University of Arizona Health Sciences.

4 Aug 2020

Portable, injectable clotting agent reduces blood loss by 97% in mice models

When it comes to traumatic injuries, it's a race against time. A person with major hemorrhage can die from blood loss within minutes, so staunching the wound and getting them to a hospital as fast as possible is critical.

31 Jul 2020

New simple way of detecting COVID-19 in blood plasma

Even as the COVID-19 pandemic claims increasing numbers of patients, testing numbers are rising in most nations at the leading edge. However, the current reverse transcriptase-polymerase chain reaction (RT PCR) testing is often unavailable and takes up to several days for results to arrive.

31 Jul 2020

Platelet hyperreactivity, a unique feature of COVID-19

A new study by Irish researchers and published in the preprint server medRxiv in July 2020 reports a bidirectional relationship between COVID-19 and coagulation abnormalities.

29 Jul 2020

Case Western Reserve University scientist receives DoD grant to develop freeze-dried artificial platelets

A Case Western Reserve University scientist, who has for more than a decade pioneered research into synthetic platelet substitutes, has been awarded a $3.8 million grant by the U.S. Department of Defense (DOD) to develop freeze-dried artificial platelets that can treat bleeding in wounded soldiers in the battlefield before they can be taken to a hospital.

22 Jul 2020

A multi-omics single cell analysis on COVID-19

Now, a new study published on the preprint server medRxiv aims to analyze the immune response over time, using multi-omics in the study of a single cell.

21 Jul 2020

Peptide-derived nanoparticle drug shows promise for treating heart attack

Researchers at the University of Illinois at Chicago have developed a new drug that prevents blood clots without causing an increased risk of bleeding, a common side effect of all antiplatelet medications currently available.

15 Jul 2020

Certain antibodies may cause the dangerous part of COVID-19 disease

A new study out of the Netherlands and published on the preprint server bioRxiv* in July 2020 discusses the commonly observed phenomenon of COVID-19 progression at 1-2 weeks from the onset of the earliest symptoms. This is ascribed to the overactivation of the inflammatory signaling cascade triggered by a hyperactive adaptive immune reaction, commonly called the cytokine storm.

15 Jul 2020

New clinical trial to assess safety and efficacy of convalescent plasma to prevent COVID-19

There is only one approved, specific treatment for COVID-19, the illness caused by the novel coronavirus SARS-CoV-2, albeit with modest efficacy.

10 Jul 2020

Study explores the role of gut Piezo1 in sensing of bacterial RNA

In a new study published in Cell, "RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis", a research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences explored the role of Piezo1, a mechano-sensing receptor, in the sensing of bacterial RNA.

7 Jul 2020

COVID-19 complications may be associated with von Willebrand factor in the blood

Anna Aksenova, a senior research associate at the Laboratory of Amyloid Biology at St Petersburg University, has advanced a hypothesis that the severe course of COVID-19 may be associated with von Willebrand factor.

6 Jul 2020

Repurposed drug for acute lung injury in COVID-19

Now, a new study addresses the possible use of an FDA-approved monoclonal antibody, called fostamatinib, a spleen tyrosine kinase inhibitor (SYK), to reduce the levels of mucin-1, a molecule associated with acute lung injury and acute respiratory distress syndrome (ARDS). People who have severe COVID-19 disease may develop ARDS.

2 Jul 2020

COVID-19 triggers changes in blood platelets

Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious complications in some patients who have the disease, according to University of Utah Health scientists.

30 Jun 2020

Overactive neutrophils may drive life-threatening blood clots in some COVID-19 patients

Scientists have new evidence that overactive neutrophils--a common type of circulating immune cell--may drive the life-threatening blood clots and inflammation that occur in some patients with COVID-19.

29 Jun 2020

HORIBA Medical white paper provides a review of hematology biomarkers for COVID-19 assessment

As experts in hematology HORIBA UK Ltd, Medical announces that the Company has published a white paper entitled, ‘COVID-19 screening, prognosis and severity assessment with biomarkers for management of patients’.

From HORIBA Medical 26 Jun 2020

Platelets may be contributing to COVID-19

The current pandemic of COVID-19 is characterized mainly by severe acute respiratory distress of the lungs, but other organ dysfunctions are also being observed, including the heart and blood vessels. Now, a new paper published on the preprint server medRxiv* in June 2020 describes the abnormal activation of platelets in this disease and the link between this phenomenon and poor outcomes for COVID-19 patients.

24 Jun 2020

Study takes new treatment approach for blood cancer

In an effort to improve the survival of patients with myeloproliferative neoplasms, a type of leukemia, researchers inhibited a specific protein (alpha5beta1 integrin) to decrease the number of large bone marrow cells (megakaryocytes) in an experimental model.

21 Jun 2020

Researchers find prothrombotic antibodies in patients with COVID-19

Even as the COVID-19 pandemic continues to spread across the world, researchers are still trying to understand the many ways in which it can manifest and its pathogenesis. A new report published on the preprint server medRxiv* in June 2020 shows that one possible mechanism of disease in COVID-19 is the production of antiphospholipid antibodies.

19 Jun 2020