Clinical Trial News and Research

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All-cause mortality risk higher among individuals with head injury

Adults who suffered any head injury during a 30-year study period had two times the rate of mortality than those who did not have any head injury, and mortality rates among those with moderate or severe head injuries were nearly three times higher, according to new research from the Perelman School of Medicine at the University of Pennsylvania, published today in JAMA Neurology.

23 Jan 2023

"The Trust Circle": Inclusion of indigenous patients in clinical trials

Indigenous populations, including people of American Indian and Alaska Native origin, are underrepresented in clinical trials.

23 Jan 2023

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Immunotherapies have improved outcomes of many patients with cancer, including melanoma. But these therapies work for only a subset of patients.

23 Jan 2023

CHLA launches first clinical trial for Down syndrome regression disorder with $5.3 million NIH grant

Children's Hospital Los Angeles has launched the first clinical trial for Down syndrome regression disorder (DSRD), a rare and debilitating condition that affects adolescents and young adults with Down syndrome.

23 Jan 2023

Study reviews mechanistic data on new methods of allergy prevention and treatment

In a recent article published in Science Translational Medicine, researchers reviewed the cause and the underlying pathophysiology of allergic diseases.

23 Jan 2023

New research evaluates clinical trials investigating post-acute COVID-19 syndrome treatment

In a recent article published in Clinical Microbiology and Infection, researchers reviewed all registered trials currently investigating potential treatment options for post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS).

23 Jan 2023

What was the prevalence of adverse events following first and second dose COVID-19 vaccinations in England?

A recent Eurosurveillance study focused on estimating the incidence of a prespecified list of adverse events following the first and second doses of the COVID-19 vaccination.

23 Jan 2023

Using motion capture technology and AI to monitor the progression of movement disorders

A multi-disciplinary team of researchers has developed a way to monitor the progression of movement disorders using motion capture technology and AI.

23 Jan 2023

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally 'blunted'.

23 Jan 2023

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

In a recent study published in The Lancet Microbe journal, researchers described the effectiveness of a modular capsid virus-like coronavirus disease 2019 (COVID-19) vaccination.

22 Jan 2023

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

A four-drug chemotherapy regimen provided longer overall survival than a two-drug combination in a Phase 3 clinical trial for metastatic pancreatic ductal adenocarcinoma.

20 Jan 2023

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Adding nab-paclitaxel to a standard treatment of gemcitabine plus cisplatin does not significantly extend median overall survival (OS) time for patients with advanced biliary tract cancers, although it may provide a benefit for subsets of patients with locally advanced disease or gallbladder adenocarcinoma.

20 Jan 2023

Researchers create the first 'living medicine' to treat drug-resistant lung infections

Researchers have designed the first 'living medicine' to treat lung infections. The treatment targets Pseudomonas aeruginosa, a type of bacteria which is naturally resistant to many types of antibiotics and is a common source of infections in hospitals.

19 Jan 2023

Team-oriented approach improves the risk of acquiring post-procedural acute kidney injury

Findings from a new study published in The Clinical Journal of the American Society of Nephrology, involving a collaborative effort between researchers at Dartmouth's Geisel School of Medicine, Vanderbilt, and Veteran's Affairs (VA) medical centers, show that an implementation science approach using team-based coaching and automated surveillance reporting significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions.

19 Jan 2023

Vaccinated women well protected against severe COVID-19 symptoms, complications during pregnancy

The global network led by the Oxford Maternal and Perinatal Health Institute (OMPHI) at the University of Oxford has today published, in the Lancet, the results of the '2022 INTERCOVID Study' conducted in 41 hospitals across 18 countries.

19 Jan 2023

New scan reliably detects primary aldosteronism, a common cause of hypertension

In a recent article, researchers performed a prospective within-patient clinical trial, Is Metomidate superior to AVS in predicting ouTComes from adrenalectomy in primary Hyperaldosteronism (MATCH) in the United Kingdom (UK) in primary aldosteronism (PA) patients. These patients suffered from high blood pressure caused by a steroid hormone, aldosterone.

19 Jan 2023

Clinical Trial News and Research

All-cause mortality risk higher among individuals with head injury

"The Trust Circle": Inclusion of indigenous patients in clinical trials

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

CHLA launches first clinical trial for Down syndrome regression disorder with $5.3 million NIH grant

Study reviews mechanistic data on new methods of allergy prevention and treatment

New research evaluates clinical trials investigating post-acute COVID-19 syndrome treatment

What was the prevalence of adverse events following first and second dose COVID-19 vaccinations in England?

Using motion capture technology and AI to monitor the progression of movement disorders

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Phase I trial results from AdaptVac's COVID capsid virus-like particle vaccine

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Researchers create the first 'living medicine' to treat drug-resistant lung infections

Team-oriented approach improves the risk of acquiring post-procedural acute kidney injury

Vaccinated women well protected against severe COVID-19 symptoms, complications during pregnancy

New scan reliably detects primary aldosteronism, a common cause of hypertension

Group-based CBT relieves psychological distress, improves quality of life in younger heart patients

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

What does the future of clinical trials and evidence-based medicine look like?

The efficacy of low-dose fluvoxamine compared with placebo for treating mild to moderate COVID-19 in the US

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