Clinical Trial News and Research

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Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

A promising approach to control Staphylococcus aureus bacterial colonization in people - using a probiotic instead of antibiotics - was safe and highly effective in a Phase 2 clinical trial.

17 Jan 2023

Study finds no difference in the survival benefit of two diuretics for heart failure patients

Two drugs widely used to treat adults with heart failure – furosemide and torsemide – showed no difference in their ability to improve patient survival when compared, according to findings from a clinical trial supported by the National Institutes of Health.

17 Jan 2023

Simple nasal spray effective at easing sleep-disordered breathing in children

A simple nasal spray significantly reduced snoring and breathing difficulties in children and halved the number needing to have their tonsils removed, according to a new study.

17 Jan 2023

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

For people with paralysis caused by neurologic injury or disease - such as ALS (also known as Lou Gehrig's disease), stroke, or spinal cord injury - brain-computer interfaces (BCIs) have the potential to restore communication, mobility, and independence by transmitting information directly from the brain to a computer or other assistive technology.

16 Jan 2023

Participants using Huma's clinical trial platform have high levels of engagement in COVID-19 study

Huma Therapeutics Limited ("Huma"), a leading global digital health company, today announced results of a new study in collaboration with the Medical Research Council Epidemiology Unit at the University of Cambridge showing that participants using Huma's clinical trial platform had high, sustained levels of engagement in an observational, fully remote COVID-19 study.

13 Jan 2023

Risks and benefits of recently approved Alzheimer’s drug

The U.S. Food and Drug Administration (FDA) recently granted approval to Lecanemab, the first Alzheimer's disease treatment to win approval since the largely failed rollout of Aduhelm two years ago.

13 Jan 2023

New drug combination may offer better prognosis for children diagnosed with deadly brain cancer

Researchers at the University of Colorado Anschutz Medical Campus have discovered a drug combination that may offer a better prognosis for children diagnosed with MYC amplified Medulloblastoma, an often deadly form of brain cancer.

13 Jan 2023

Review and meta-analysis suggests breathwork may be effective for improving stress and mental health

The findings of a study published in Scientific Reports suggest that practicing breathing exercises helps decrease stress and improve mental health.

13 Jan 2023

New cooling strategy could prevent the growth of glioblastoma

Cooling brain tumor cells to stop them from dividing without killing healthy cells extended the survival of glioblastoma (GBM) animal models dramatically in a study led by a UT Southwestern resident.

12 Jan 2023

Machine learning-based behavioral intervention can improve end-of-life cancer care

Electronic nudges delivered to health care clinicians based on a machine learning algorithm that predicts mortality risk quadrupled rates of conversations with patients about their end-of-life care preferences, according to the long-term results of a randomized clinical trial published by Penn Medicine investigators in JAMA Oncology today.

12 Jan 2023

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

Posoleucel, an investigational allogeneic off-the-shelf T-cell therapy that simultaneously targets six different viruses, demonstrated promising antiviral efficacy and safety in a phase II study of patients who had undergone stem cell transplantation to treat their cancer or other blood diseases.

11 Jan 2023

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

CAR T cell therapy, an approach which reprograms patients' own immune cells to attack their blood cancers, may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

11 Jan 2023

Medicare policy change may lead to increased inequities in access to heart transplants

A change to Medicare policy surrounding heart transplant may lead to increased inequities in access to transplant for patients with heart failure, a Michigan Medicine study finds.

11 Jan 2023

Hormonal therapy may aid in reducing progression of early-stage prostate cancer during active surveillance

For men with early-stage prostate cancer being managed by active surveillance, adding the hormonal agent apalutamide may lower the rate of positive biopsies during follow-up, suggests a preliminary clinical trial in The Journal of Urology, an Official Journal of the American Urological Association.

11 Jan 2023

Performing acts of kindness may help people suffering from depression or anxiety

People suffering from symptoms of depression or anxiety may help heal themselves by doing good deeds for others, new research shows.

10 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023

Daily intake of almonds changes the metabolism to recover faster after exercise

A new randomized controlled trial showed that participants who daily ate 57g almonds over four weeks had a 69% higher level of the beneficial oxylipin molecule 12,13-dihydroxy-9Z-octadecenoic acid in their blood after a 90 minute session of eccentric exercise than control volunteers.

10 Jan 2023

Study uncovers molecular features responsible for the development, progression of metastatic breast cancer

A multi-institutional national study has identified unique molecular features responsible for the development and progression of metastatic breast cancer.

9 Jan 2023

Novel T cell receptor therapy shows early promise for treating solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

9 Jan 2023

Clinically relevant biomarker strategies in drug development

In this interview, NewsMedical speaks with Dr. Justin Devine and Dr. Nicholas Woudberg about biomarkers, their importance for drug development as well as the potential they have when it comes to machine learning.

From Synexa Life Sciences 9 Jan 2023

Clinical Trial News and Research

Probiotic diminishes S. aureus bacterial colonization, Phase 2 trial shows

Study finds no difference in the survival benefit of two diuretics for heart failure patients

Simple nasal spray effective at easing sleep-disordered breathing in children

Brain-computer interfaces' safety is similar to other implanted neurologic devices, study shows

Participants using Huma's clinical trial platform have high levels of engagement in COVID-19 study

Risks and benefits of recently approved Alzheimer’s drug

New drug combination may offer better prognosis for children diagnosed with deadly brain cancer

Review and meta-analysis suggests breathwork may be effective for improving stress and mental health

New cooling strategy could prevent the growth of glioblastoma

Machine learning-based behavioral intervention can improve end-of-life cancer care

Investigational T-cell therapy shows antiviral efficacy and safety in cancer patients treated with stem cell transplant

CAR T cell therapy may enhance the effectiveness of surgery for solid tumors

Medicare policy change may lead to increased inequities in access to heart transplants

Hormonal therapy may aid in reducing progression of early-stage prostate cancer during active surveillance

Performing acts of kindness may help people suffering from depression or anxiety

Anticancer drugs offer new hope for treatment of sepsis

Daily intake of almonds changes the metabolism to recover faster after exercise

Study uncovers molecular features responsible for the development, progression of metastatic breast cancer

Novel T cell receptor therapy shows early promise for treating solid tumors

Clinically relevant biomarker strategies in drug development

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