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Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

14 Feb 2022

Study identifies a link between mortality of newborns on ECMO and red blood cell transfusion volume

Newborns in respiratory failure who require the life-sustaining support of ECMO also require transfusion of red blood cells. But a new study indicates that the higher volume of these oxygen-carrying blood cells the babies receive, the higher their mortality rate.

14 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

A study in mice - led by researchers at Washington University School of Medicine in St. Louis - shows that a new class of compounds the scientists developed can improve multiple aspects of metabolic syndrome.

12 Feb 2022

Liver cirrhosis has higher hospitalization and in-hospital mortality rates in Germany

In Germany, liver cirrhosis has the highest mortality rate of any chronic disease requiring hospital admission. When diagnosed as a comorbidity of other chronic diseases, liver cirrhosis at least doubles the mortality rate.

12 Feb 2022

Hazards of persistent and new clinical sequelae caused by SARS-CoV-2 infection among elderly patients

A new study estimated the risk and hazards of persistent and new clinical sequelae of the SARS-CoV-2 infection among elderly patients (above 65 years or older) during the post-acute phase of the infection.

11 Feb 2022

Study: Almost a third of older adults infected with covid-19 develop new conditions

Almost a third (32 of every 100) of older adults infected with covid-19 in 2020 developed at least one new condition that required medical attention in the months after initial infection, 11 more than those who did not have covid-19, finds a US study published by The BMJ today.

10 Feb 2022

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Scientists have a new understanding of the protective effects of caffeine on the cardiovascular system. While its stimulant effects have long been characterized, a team of Canadian researchers have discovered how caffeine interacts with key cellular factors to remove cholesterol from the bloodstream.

10 Feb 2022

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Researchers studied the preclinical PK) and in vitro ADME properties of GS-441524, a potential oral drug for COVID-19 treatment.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

The serious risks COVID-19 may pose during pregnancy

Researchers report on the potential for serious maternal illness or death during or following a pregnancy complicated by COVID-19.

9 Feb 2022

Research may lead to the development of effective fasting-based therapies

Voluntary fasting, for example interval fasting, is beneficial to health for many people, depending on their individual condition. For example, controlled periods of starvation can prevent and improve diseases such as diabetes and obesity.

9 Feb 2022

Study explores inflammation of endothelial cells by exosomes from COVID-19 patients

In a new study, researchers revealed that the nucleotide-binding oligomerization domain-like receptors or NOD-like receptors family pyrin domain containing 3 (NLRP3) inflammasome is activated by the exosomes from plasma in COVID-19.

9 Feb 2022

Study finds 50% increase in hospitalizations for alcoholic hepatitis in early months of the pandemic

In new research published in Liver International, researchers at Henry Ford Health System have found that people hospitalized for alcoholic hepatitis – a life threatening liver disease fueled by alcohol use – increased a staggering 50 percent in the early months of the COVID-19 pandemic.

9 Feb 2022

30-year-old cancer drug could get another shot, study says

A study by Virginia Commonwealth University Massey Cancer Center researchers published in today's print edition of Molecular Cancer Therapeutics shows that triplatin is effective against triple negative breast cancer, which is the most aggressive form of breast cancer and has few targeted therapies.

9 Feb 2022

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

Mycology and immunology researchers from The University of Texas at San Antonio have been selected to receive a five-year, $6.8 million grant from the National Institutes of Health to establish a San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC) focused on developing therapeutics and vaccines against coccidioidomycosis.

8 Feb 2022

NIH grant renewal will enable Nebraska scientist to advance research on virtual immune system

The renewal of a National Institutes of Health grant will enable a University of Nebraska-Lincoln researcher to continue developing a tool that illuminates the complex, multi-scale interplay of the immune system's many components.

8 Feb 2022

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

In a recent study published in the journal ACS Applied Bio Materials, researchers demonstrated the inhibitory potential of curcumin-encapsulated polysaccharide nanoparticles (CUR−PS-NPs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV2-SP)-stimulated cytokine storm in lung and liver epithelial cells.

8 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

In a study posted to the bioRxiv* preprint server, a team of researchers from Germany studied the expression data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-relevant genes such as angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and the G-protein coupled receptor Mas in an alcohol-exposed rodent model infected with SARS-CoV-2.

7 Feb 2022

Liver News and Research

Discovery may lead to new treatment approach for people with alcohol-associated liver disease

Study identifies a link between mortality of newborns on ECMO and red blood cell transfusion volume

Hundreds of new proteins that could play a role in cystic fibrosis discovered

New class of compounds can improve multiple aspects of metabolic syndrome, mice study shows

Liver cirrhosis has higher hospitalization and in-hospital mortality rates in Germany

Hazards of persistent and new clinical sequelae caused by SARS-CoV-2 infection among elderly patients

Study: Almost a third of older adults infected with covid-19 develop new conditions

Study provides new understanding of caffeine's protective effects on the cardiovascular system

Properties and pharmacokinetics an oral drug candidate for COVID-19 treatment

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

The serious risks COVID-19 may pose during pregnancy

Research may lead to the development of effective fasting-based therapies

Study explores inflammation of endothelial cells by exosomes from COVID-19 patients

Study finds 50% increase in hospitalizations for alcoholic hepatitis in early months of the pandemic

30-year-old cancer drug could get another shot, study says

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

NIH grant renewal will enable Nebraska scientist to advance research on virtual immune system

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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