Preclinical News and Research

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Circulating molecules in the blood may be new markers of type 1 diabetes

Researchers from the Turku Bioscience Centre in Finland have found changes in molecules in the blood that might be new markers of type 1 diabetes. New findings may help understand the early pathogenesis of the disease.

19 Sep 2019

Getting new therapy to patients can be harder than putting a lander on Mars

Getting new medical treatments from the lab benchtop to patients' bedsides can be harder and more expensive than putting a lander on Mars. But it doesn't have to be, says Tiffany Wilson, who heads a nonprofit organization that guides new medical solutions from the lab bench to the bedside.

19 Sep 2019

Prilenia's lead compound selected to participate in first-ever ALS platform trial

Prilenia, a newly formed biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, announces that Pridopidine, its lead compound, has been selected as the first of three potential new treatments to be included in the launch of the first ever platform trial in amyotrophic lateral sclerosis (ALS).

19 Sep 2019

Zylka lab receives NIH grant to advance treatments for neurodevelopmental disorders

The National Institutes of Health have awarded two separate grants totaling $6.1 million to Mark Zylka, PhD, director of the UNC Neuroscience Center. One of the grants was co-awarded to Ben Philpot, PhD, associate director of the center at the UNC School of Medicine.

18 Sep 2019

Cannabidiol may alleviate seizures and normalize brain rhythms in Angelman syndrome

A marijuana plant extract, also known as cannabidiol, is being commonly used to improve anxiety, sleep problems, pain, and many other neurological conditions.

18 Sep 2019

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center.

18 Sep 2019

Anti-cancer effects of lycopene in tomatoes canceled out by iron-rich foods

Tomatoes have proven cancer-fighting properties, but new research suggests that eating them with iron-rich meats can destroy this effect.

18 Sep 2019

New results revealed from pilot stem cell study for stroke

Researchers led by Sean I. Savitz, MD, reported today in the journal Stem Cells that bone marrow cells used to treat ischemic stroke in an expanded Phase I trial were not only safe and feasible, but also resulted in enhanced recovery compared to a matched historical control group.

17 Sep 2019

Uncovering new T cell regulatory processes could help treat autoimmune disease

One of the important cells involved in the immune response is the T follicular helper (Tfh) cell. These are important in the normal process of antibody production following immunization, for instance. However, they are also abnormally increased in number in patients with autoimmune disease, such as systemic lupus erythematosus.

16 Sep 2019

Study shows how the interplay of two cytokines affects development of Tfh cells

The body's immune response fights against infectious disease, and it safeguards against future infections through vaccination.

15 Sep 2019

CRISPR may explain why so many experimental cancer drugs fail

Scientists have used CRISPR–Cas9 to investigate how ten cancer drugs interact with their protein target, revealing some intriguing findings.

13 Sep 2019

Distinctive characteristics in lung cancers could be key to personalized therapies

Melbourne researchers have discovered that the key to personalized therapies for some types of lung cancers may be to focus on their differences, not their similarities.

13 Sep 2019

Promising new drug being developed for polycystic kidney disease

Researchers have developed a potential new drug for the treatment of Polycystic kidney disease (PKD) – a deadly genetic condition affecting the kidneys that leads to formation of swellings or cysts within the kidney that cause it to fail.

12 Sep 2019

Papilloma viruses capable of spreading via blood

Human Papilloma Virus or HPV has been known to be transmitted between humans via sexual contact and HPV has been known to be a sexually transmitted disease or STD. The Centers for Disease Control and Prevention (CDC) states that HPV is one of the commonest STDs among humans.

12 Sep 2019

Age affects efficacy of immunotherapy treatment for breast cancer, preclinical study reveals

Recent clinical trials have indicated that immune checkpoint blockade (ICB) therapy, which is designed to unleash a patient's immune system to attack cancer, has been revolutionary in its implications for breast cancer treatment, especially for its potential to treat patients with triple negative breast cancer.

8 Sep 2019

Researchers find synergistic connection between two deadly blood-clotting diseases

Two rare but potentially deadly blood-clotting diseases, namely thrombotic thrombocytopenic purpura, or TTP, and hemolytic uremic syndrome, or HUS, show similar pathologies -- a multitude of painful blockages in small blood vessels that cause varying degrees of organ injury throughout the body. However, the two disorders have distinct biological mechanisms.

8 Sep 2019

NIH trial aims to improve drug discovery for ischemic stroke

The NIH has announced it will fund a nationwide preclinical trial focusing on robust testing of new treatments for acute ischemic stroke.

4 Sep 2019

Study aims to achieve earlier diagnosis of ATTR cardiac amyloidosis in minority populations

Researchers at Boston Medical Center and Boston University School of Medicine, in collaboration with Columbia University Irving Medical Center, are leading a national, multi-site study aimed to achieve earlier diagnosis of transthyretin cardiac amyloidosis.

4 Sep 2019

Cracking the code of a recurrent brain cancer

One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with a vengeance to then turn deadly.

30 Aug 2019

A detailed map to understand how viruses infect human cells

Biologists at Columbia University Vagelos College of Physicians and Surgeons have leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect.

29 Aug 2019

Preclinical News and Research

Circulating molecules in the blood may be new markers of type 1 diabetes

Getting new therapy to patients can be harder than putting a lander on Mars

Prilenia's lead compound selected to participate in first-ever ALS platform trial

Zylka lab receives NIH grant to advance treatments for neurodevelopmental disorders

Cannabidiol may alleviate seizures and normalize brain rhythms in Angelman syndrome

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

Anti-cancer effects of lycopene in tomatoes canceled out by iron-rich foods

New results revealed from pilot stem cell study for stroke

Uncovering new T cell regulatory processes could help treat autoimmune disease

Study shows how the interplay of two cytokines affects development of Tfh cells

CRISPR may explain why so many experimental cancer drugs fail

Distinctive characteristics in lung cancers could be key to personalized therapies

Promising new drug being developed for polycystic kidney disease

Papilloma viruses capable of spreading via blood

Age affects efficacy of immunotherapy treatment for breast cancer, preclinical study reveals

Researchers find synergistic connection between two deadly blood-clotting diseases

NIH trial aims to improve drug discovery for ischemic stroke

Study aims to achieve earlier diagnosis of ATTR cardiac amyloidosis in minority populations

Cracking the code of a recurrent brain cancer

A detailed map to understand how viruses infect human cells

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