Preclinical News and Research

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Potential drug could revolutionize the treatment of neurological conditions

The international team of scientists from Gero Discovery LLC, the Institute of Biomedical Research of Salamanca, and Nanosyn, Inc. has found a potential drug that may prevent neuronal death through glucose metabolism modification in stressed neurons.

28 Aug 2019

New cellular processes controlling the formation of lymphatic valves found

Lymphedema, resulting from a damaged lymphatic system, can be a debilitating disease in which excess protein-rich fluid (lymph) collects in soft tissues and causes swelling -- most often in the arms or legs.

28 Aug 2019

New drug combination shows promise for treating non-small cell lung cancer patients

Patients with non-small cell lung cancer now have more improved treatment options compared to standard of care with the addition of several new agents called immune-checkpoint inhibitors.

27 Aug 2019

Promising new strategy to treat severe dengue disease on the horizon

Researchers led by Duke-NUS Medical School have discovered that tryptase, an enzyme in human cells that acts like scissors to cut up nearby proteins, is responsible for blood vessel leakage in severe dengue hemorrhagic fever.

27 Aug 2019

Researchers demonstrate the effectiveness of new bladder cancer treatment

Researchers from the Molecular Cancer group at the Hospital del Mar Medical Research Institute and doctors from Hospital del Mar, have demonstrated the effectiveness of a drug for treating metastatic bladder cancer in patients who did not respond to the usual treatment.

27 Aug 2019

Researchers decode chain of molecules critical for growth and survival of pancreatic cancer

Researchers at Georgetown Lombardi Comprehensive Cancer Center have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma (PDAC) - the most common and also the most lethal form of pancreatic cancer.

23 Aug 2019

Head-to-head comparison of three breast cancer drugs reveals important differences

Every year, more than 250,000 women in the U.S. are diagnosed with breast cancer. When detected early, patients with the most common form--which tests positive for hormone receptors (HR+) and negative for the HER2 receptor--usually respond well to treatment.

23 Aug 2019

Computer model could be used to quickly evaluate new drugs for sickle cell disease

A team of Brown University researchers has developed a new computer model that simulates the way red blood cells become misshapen by sickle cell disease.

22 Aug 2019

Kawasaki Medical University installs first MILabs E-Class U-SPECT6/CT in Japan

Kawasaki Medical University, Yokohama’s research hub for state-of-the-art medical science and services has acquired anultra-high-resolutionE-ClassU-SPECT6/CT system for preclinical imaging.

22 Aug 2019

New cannabis-based drug shows promise for pancreatic cancer

Cancer of the pancreas is a particularly deadly cancer, claiming over 90% of its victims within 5 years from diagnosis. It resists most standard therapies, including surgery, chemotherapy, radiation therapy, immunotherapy and targeted therapy, and metastasizes early, often before being diagnosed. A cure is possible only with very localized tumors.

22 Aug 2019

Northern Antibiotics working on a new molecule to fight antibiotic-resistant bacteria

Each year, around 60,000 deaths are caused by antibiotic-resistant bacteria in Europe and the U.S., and this number is growing.

21 Aug 2019

FDA clears its IND for new immunotherapeutic for treating prostate cancer

Calibr, the drug development division of Scripps Research, announced today that the U.S. Food and Drug Administration has cleared its investigational new drug application for CCW702, a novel immunotherapeutic for the treatment of patients with metastatic castration-resistant prostate cancer.

21 Aug 2019

Middle-life hypertension may shrink the brain in later life

A long-running study which ha been following up people into their seventies concludes that high blood pressure between the age of 36 and 53 years is associated with brain pathology such as white matter lesions and brain shrinkage in later life. To prevent this, blood pressure should be monitored beginning at or before 40 years, suggest the researchers.

21 Aug 2019

Lipid signaling pathway may enhance T cell-mediated immunotherapy

The immune system surveils our body looking for things that don't belong, often bacteria and viruses. While cancer cells are abnormal cells that undergo unregulated cell growth, they are good at evading detection by the immune system.

19 Aug 2019

Study shows synergistic effects of drugs that inhibit cell division in pancreatic cancer

Pancreatic cancer is one of the deadliest cancers, with patients surviving on average less than a year once the disease has spread.

19 Aug 2019

Discover the latest advances in neuromuscular therapeutics at NMD 2019

The 2nd Neuromuscular Drug Development Summit, or NMD, will be held in Boston, MA, from October 23-25,2019.

From Hanson Wade 19 Aug 2019

Researchers discover how stress can decrease the desire to eat

Eating disorder researchers at The University of Texas Health Science Center at Houston (UTHealth) have discovered a neurocircuit in mice that, when activated, increased their stress levels while decreasing their desire to eat. Findings appear in Nature Communications.

18 Aug 2019

Nanotube fibers used to rewire damaged hearts

Thin, flexible fibers made of carbon nanotubes have now proven able to bridge damaged heart tissues and deliver the electrical signals needed to keep those hearts beating.

13 Aug 2019

SU2C Dream Team to develop new drug combination to stop spread of breast cancer

At a press conference at McGill University today, Stand Up To Cancer Canada, the Canadian Cancer Society, and the Canadian Institutes of Health Research announced the launch of the SU2C Canada Metastatic Breast Cancer Dream Team to pursue the development of a new drug combination that may help stop the spread of breast cancer to other organs of the body.

13 Aug 2019

Depression symptoms together with AD pathology could trigger changes in memory and thinking

Increasingly, Alzheimer's disease research has focused on the preclinical stage, when people have biological evidence of AD but no or minimal symptoms, and when interventions might have the potential to prevent future decline of older adults.

10 Aug 2019

Preclinical News and Research

Potential drug could revolutionize the treatment of neurological conditions

New cellular processes controlling the formation of lymphatic valves found

New drug combination shows promise for treating non-small cell lung cancer patients

Promising new strategy to treat severe dengue disease on the horizon

Researchers demonstrate the effectiveness of new bladder cancer treatment

Researchers decode chain of molecules critical for growth and survival of pancreatic cancer

Head-to-head comparison of three breast cancer drugs reveals important differences

Computer model could be used to quickly evaluate new drugs for sickle cell disease

Kawasaki Medical University installs first MILabs E-Class U-SPECT6/CT in Japan

New cannabis-based drug shows promise for pancreatic cancer

Northern Antibiotics working on a new molecule to fight antibiotic-resistant bacteria

FDA clears its IND for new immunotherapeutic for treating prostate cancer

Middle-life hypertension may shrink the brain in later life

Lipid signaling pathway may enhance T cell-mediated immunotherapy

Study shows synergistic effects of drugs that inhibit cell division in pancreatic cancer

Discover the latest advances in neuromuscular therapeutics at NMD 2019

Researchers discover how stress can decrease the desire to eat

Nanotube fibers used to rewire damaged hearts

SU2C Dream Team to develop new drug combination to stop spread of breast cancer

Depression symptoms together with AD pathology could trigger changes in memory and thinking

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